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EC number: 205-517-7 | CAS number: 141-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
Description of key information
There are conclusive but not suffcient data for the classification of substance IPETC/O-isopropyl ethylthiocarbamate with regard to Neurotoxicity.
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Link to relevant study records
- Endpoint:
- neurotoxicity: short-term oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/ O-isopropyl ethylthiocarbamate . Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/ O-isopropyl ethylthiocarbamate.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 426 (Developmental Neurotoxicity Study)
- Deviations:
- no
- GLP compliance:
- not specified
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Inc. Raleigh, NC
- Age at study initiation: 9 weeks on gestation day 0
- Weight at study initiation: 174-197 g on gestation day 0
- Fasting period before study: None
- Housing: singly caged in solid bottom polycarbonate cages with stainless steel wire lids
- Diet (e.g. ad libitum): 5002 Purina certified rodent chow was available ad libitum
- Water (e.g. ad libitum): tap water in polycarbonate bottles was available ad libitum
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 68-75 (20 - 24ºC)
- Humidity (%): 40-70
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light):12/12 - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS
Vehicle was deionized/distilled water - Analytical verification of doses or concentrations:
- no
- Details on analytical verification of doses or concentrations:
- Not required
- Duration of treatment / exposure:
- Administered from day 6 of gestation to day 21 post natal
- Frequency of treatment:
- daily
- Remarks:
- Doses / Concentrations:
200, 700, or 1200 mg/kg body weight/day
Basis:
actual ingested - No. of animals per sex per dose:
- 64 females/group
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Dose selection rationale: Review from 4 previous studies
- Rationale for animal assignment (if not random): sperm postive female rats were assigned to treatment groups by a stratified randomization method designed to provide uniformed mean body wieghts accross dose groups - Observations and clinical examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: No data
DETAILED CLINICAL OBSERVATIONS: Yes
- Time schedule: once daily on gestation days 0-5 and twice daily through dosing period gestation day 6 to post natal day 21
BODY WEIGHT: Yes
- Time schedule for examinations: maternal body weights were measured on gestation days 0, 6, 9, 12, 15, 18, 20 and on post natal days 0, 4, 7, 13, 17, and 21
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study): Yes
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: Yes
- Compound intake calculated as time-weighted averages from the consumption and body weight gain data: Not applicable
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): No
OPHTHALMOSCOPIC EXAMINATION: No - Specific biochemical examinations:
- NEUROPATHY TARGET ESTERASE (NTE) ACTIVITY: No
CHOLINESTERASE ACTIVITY: No
Other; one male/female pair from each dose group was sacrified on post natal day 22 for neuropathological assessment and measurement of brain weights - Neurobehavioural examinations performed and frequency:
- FUNCTIONAL OBSERVATIONAL BATTERY: No
MOTOR ACTIVITY: Yes
- Replicates used: one male/female pair from each litter was conducted on days 13, 17, 21, 47, and 58
- Type of equipment used: Figure 8 maze
- Length of session; one hour period
AUDITORY STARTLE REFLEX HABITUATION: Yes
- Number of animals: one male/female pair from each litter was conducted on days 22 and 60
- Same offspring evaluated at each preweaning time point: yes
- Exact age: Not reported
- Type of equipment used: Not reported
- Environmental conditions: Not reported
- Number of trials performed: 2
- Length (msec) and intensity (dB) of sound: 50 ms and 120 dB
- Length of interval between trials: 50 times in a session (five contiguous 10 trial blocks)
Other; Active avoidance test
- Number of animals: one male/female pair from each litter was conducted on days 60-64
- Each animal was exposed to a continous light and sound for 10 seconds following by a mild electric current delivered to a foot grid for 30 seconds. - Sacrifice and (histo)pathology:
- MATERNAL ANIMALS
- Time point of sacrifice or discard without postmortem examination: post natal day 22
- Method of sacrifice: asphyxiation with CO2
- Postmortem evaluations;
- Necropsy: Yes
- Brain weight: Yes
- Other organ weights: Yes
- Histopathology: Yes
OFFSPRING
- Time point of sacrifice of offspring selected for brain weight or neuropathological evaluation: postnatal day 22
- Description of postmortem examinations:
- At postnatal day 22 one male and one female per group were selected for brain weight measurements
- The brains from these pups/sex/group were immersion fixed and embedded in paraffin, blocked, sectioned, and stained with hematoxylin and eosin.
- Histopathological examination was performed on tissues from control and high-dose pups.
- On postnatal day 4, pups that were culled were euthanized and necropsied.
- On postnatal day 68, the remaining animals were necropsied. - Other examinations:
- None
- Positive control:
- No postive control was used
- Statistics:
- A combination of categorical, analysis of variance, survival time, and repeated measures techniques were used.
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Behaviour (functional findings):
- no effects observed
- Gross pathological findings:
- no effects observed
- Neuropathological findings:
- no effects observed
- Other effects:
- no effects observed
- Description (incidence and severity):
- Migrated information from 'Further observations for developmental neurotoxicity study'
Details on results (for developmental neurotoxicity):OTHER FINDINGS
- no significant findings in the motor activity test, startle test, and the active avoidance test. (migrated information) - Details on results:
- One maternal animal died in the 1200 dose group on post natal day 15.
The mean food consumption of females in the 700 dose group was significantly increased but only on post natal days 0-3. - Dose descriptor:
- NOAEL
- Effect level:
- 700 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: based on the death of 1 animal in the high-dose group
- Remarks on result:
- other: Generation: maternal (migrated information)
- Dose descriptor:
- NOAEL
- Effect level:
- 1 200 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: No adverse effects
- Remarks on result:
- other: Generation: offspring (migrated information)
- Conclusions:
- NOEL Maternal Toxicity = 700 mg/kg bw/day
There was no evidence of developmental neurotoxicity associated with isopropanol exposure as high as 1200 mg/kg/day (NOEL Developmental Neurotoxicity = 1200 mg/kg bw/day) .
Propan-2-ol (Isopropyl alcohol) as a main constituent of IPETC/ O-isopropyl ethylthiocarbamate and need to be considered in the assessment of IPETC/ O-isopropyl ethylthiocarbamate .
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 200 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Effect on neurotoxicity: via inhalation route
Link to relevant study records
- Endpoint:
- neurotoxicity: short-term oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/ O-isopropyl ethylthiocarbamate . Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/ O-isopropyl ethylthiocarbamate.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 426 (Developmental Neurotoxicity Study)
- Deviations:
- no
- GLP compliance:
- not specified
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Inc. Raleigh, NC
- Age at study initiation: 9 weeks on gestation day 0
- Weight at study initiation: 174-197 g on gestation day 0
- Fasting period before study: None
- Housing: singly caged in solid bottom polycarbonate cages with stainless steel wire lids
- Diet (e.g. ad libitum): 5002 Purina certified rodent chow was available ad libitum
- Water (e.g. ad libitum): tap water in polycarbonate bottles was available ad libitum
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 68-75 (20 - 24ºC)
- Humidity (%): 40-70
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light):12/12 - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS
Vehicle was deionized/distilled water - Analytical verification of doses or concentrations:
- no
- Details on analytical verification of doses or concentrations:
- Not required
- Duration of treatment / exposure:
- Administered from day 6 of gestation to day 21 post natal
- Frequency of treatment:
- daily
- Remarks:
- Doses / Concentrations:
200, 700, or 1200 mg/kg body weight/day
Basis:
actual ingested - No. of animals per sex per dose:
- 64 females/group
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Dose selection rationale: Review from 4 previous studies
- Rationale for animal assignment (if not random): sperm postive female rats were assigned to treatment groups by a stratified randomization method designed to provide uniformed mean body wieghts accross dose groups - Observations and clinical examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: No data
DETAILED CLINICAL OBSERVATIONS: Yes
- Time schedule: once daily on gestation days 0-5 and twice daily through dosing period gestation day 6 to post natal day 21
BODY WEIGHT: Yes
- Time schedule for examinations: maternal body weights were measured on gestation days 0, 6, 9, 12, 15, 18, 20 and on post natal days 0, 4, 7, 13, 17, and 21
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study): Yes
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: Yes
- Compound intake calculated as time-weighted averages from the consumption and body weight gain data: Not applicable
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): No
OPHTHALMOSCOPIC EXAMINATION: No - Specific biochemical examinations:
- NEUROPATHY TARGET ESTERASE (NTE) ACTIVITY: No
CHOLINESTERASE ACTIVITY: No
Other; one male/female pair from each dose group was sacrified on post natal day 22 for neuropathological assessment and measurement of brain weights - Neurobehavioural examinations performed and frequency:
- FUNCTIONAL OBSERVATIONAL BATTERY: No
MOTOR ACTIVITY: Yes
- Replicates used: one male/female pair from each litter was conducted on days 13, 17, 21, 47, and 58
- Type of equipment used: Figure 8 maze
- Length of session; one hour period
AUDITORY STARTLE REFLEX HABITUATION: Yes
- Number of animals: one male/female pair from each litter was conducted on days 22 and 60
- Same offspring evaluated at each preweaning time point: yes
- Exact age: Not reported
- Type of equipment used: Not reported
- Environmental conditions: Not reported
- Number of trials performed: 2
- Length (msec) and intensity (dB) of sound: 50 ms and 120 dB
- Length of interval between trials: 50 times in a session (five contiguous 10 trial blocks)
Other; Active avoidance test
- Number of animals: one male/female pair from each litter was conducted on days 60-64
- Each animal was exposed to a continous light and sound for 10 seconds following by a mild electric current delivered to a foot grid for 30 seconds. - Sacrifice and (histo)pathology:
- MATERNAL ANIMALS
- Time point of sacrifice or discard without postmortem examination: post natal day 22
- Method of sacrifice: asphyxiation with CO2
- Postmortem evaluations;
- Necropsy: Yes
- Brain weight: Yes
- Other organ weights: Yes
- Histopathology: Yes
OFFSPRING
- Time point of sacrifice of offspring selected for brain weight or neuropathological evaluation: postnatal day 22
- Description of postmortem examinations:
- At postnatal day 22 one male and one female per group were selected for brain weight measurements
- The brains from these pups/sex/group were immersion fixed and embedded in paraffin, blocked, sectioned, and stained with hematoxylin and eosin.
- Histopathological examination was performed on tissues from control and high-dose pups.
- On postnatal day 4, pups that were culled were euthanized and necropsied.
- On postnatal day 68, the remaining animals were necropsied. - Other examinations:
- None
- Positive control:
- No postive control was used
- Statistics:
- A combination of categorical, analysis of variance, survival time, and repeated measures techniques were used.
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Behaviour (functional findings):
- no effects observed
- Gross pathological findings:
- no effects observed
- Neuropathological findings:
- no effects observed
- Other effects:
- no effects observed
- Description (incidence and severity):
- Migrated information from 'Further observations for developmental neurotoxicity study'
Details on results (for developmental neurotoxicity):OTHER FINDINGS
- no significant findings in the motor activity test, startle test, and the active avoidance test. (migrated information) - Details on results:
- One maternal animal died in the 1200 dose group on post natal day 15.
The mean food consumption of females in the 700 dose group was significantly increased but only on post natal days 0-3. - Dose descriptor:
- NOAEL
- Effect level:
- 700 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: based on the death of 1 animal in the high-dose group
- Remarks on result:
- other: Generation: maternal (migrated information)
- Dose descriptor:
- NOAEL
- Effect level:
- 1 200 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: No adverse effects
- Remarks on result:
- other: Generation: offspring (migrated information)
- Conclusions:
- NOEL Maternal Toxicity = 700 mg/kg bw/day
There was no evidence of developmental neurotoxicity associated with isopropanol exposure as high as 1200 mg/kg/day (NOEL Developmental Neurotoxicity = 1200 mg/kg bw/day) .
Propan-2-ol (Isopropyl alcohol) as a main constituent of IPETC/ O-isopropyl ethylthiocarbamate and need to be considered in the assessment of IPETC/ O-isopropyl ethylthiocarbamate .
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEC
- 52.17 mg/m³
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- The oral dose for the rat is converted to the corresponding air concentration using a standard breathing volume for the rat (1.15m3/kg for 24 hours exposure. The resulting air concentration needs to be additionally corrected for 24 hlight activity (20 m3), assuming 100 % absorption for both routes.
NOAEL rat 1200 mg/kg bw/day
÷1.15m3/kgbw
÷20m3/rat
NOAECrat 52.17 mg/m3
Effect on neurotoxicity: via dermal route
Link to relevant study records
- Endpoint:
- neurotoxicity: short-term oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/ O-isopropyl ethylthiocarbamate . Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/ O-isopropyl ethylthiocarbamate.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 426 (Developmental Neurotoxicity Study)
- Deviations:
- no
- GLP compliance:
- not specified
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Inc. Raleigh, NC
- Age at study initiation: 9 weeks on gestation day 0
- Weight at study initiation: 174-197 g on gestation day 0
- Fasting period before study: None
- Housing: singly caged in solid bottom polycarbonate cages with stainless steel wire lids
- Diet (e.g. ad libitum): 5002 Purina certified rodent chow was available ad libitum
- Water (e.g. ad libitum): tap water in polycarbonate bottles was available ad libitum
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 68-75 (20 - 24ºC)
- Humidity (%): 40-70
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light):12/12 - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS
Vehicle was deionized/distilled water - Analytical verification of doses or concentrations:
- no
- Details on analytical verification of doses or concentrations:
- Not required
- Duration of treatment / exposure:
- Administered from day 6 of gestation to day 21 post natal
- Frequency of treatment:
- daily
- Remarks:
- Doses / Concentrations:
200, 700, or 1200 mg/kg body weight/day
Basis:
actual ingested - No. of animals per sex per dose:
- 64 females/group
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Dose selection rationale: Review from 4 previous studies
- Rationale for animal assignment (if not random): sperm postive female rats were assigned to treatment groups by a stratified randomization method designed to provide uniformed mean body wieghts accross dose groups - Observations and clinical examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: No data
DETAILED CLINICAL OBSERVATIONS: Yes
- Time schedule: once daily on gestation days 0-5 and twice daily through dosing period gestation day 6 to post natal day 21
BODY WEIGHT: Yes
- Time schedule for examinations: maternal body weights were measured on gestation days 0, 6, 9, 12, 15, 18, 20 and on post natal days 0, 4, 7, 13, 17, and 21
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study): Yes
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: Yes
- Compound intake calculated as time-weighted averages from the consumption and body weight gain data: Not applicable
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): No
OPHTHALMOSCOPIC EXAMINATION: No - Specific biochemical examinations:
- NEUROPATHY TARGET ESTERASE (NTE) ACTIVITY: No
CHOLINESTERASE ACTIVITY: No
Other; one male/female pair from each dose group was sacrified on post natal day 22 for neuropathological assessment and measurement of brain weights - Neurobehavioural examinations performed and frequency:
- FUNCTIONAL OBSERVATIONAL BATTERY: No
MOTOR ACTIVITY: Yes
- Replicates used: one male/female pair from each litter was conducted on days 13, 17, 21, 47, and 58
- Type of equipment used: Figure 8 maze
- Length of session; one hour period
AUDITORY STARTLE REFLEX HABITUATION: Yes
- Number of animals: one male/female pair from each litter was conducted on days 22 and 60
- Same offspring evaluated at each preweaning time point: yes
- Exact age: Not reported
- Type of equipment used: Not reported
- Environmental conditions: Not reported
- Number of trials performed: 2
- Length (msec) and intensity (dB) of sound: 50 ms and 120 dB
- Length of interval between trials: 50 times in a session (five contiguous 10 trial blocks)
Other; Active avoidance test
- Number of animals: one male/female pair from each litter was conducted on days 60-64
- Each animal was exposed to a continous light and sound for 10 seconds following by a mild electric current delivered to a foot grid for 30 seconds. - Sacrifice and (histo)pathology:
- MATERNAL ANIMALS
- Time point of sacrifice or discard without postmortem examination: post natal day 22
- Method of sacrifice: asphyxiation with CO2
- Postmortem evaluations;
- Necropsy: Yes
- Brain weight: Yes
- Other organ weights: Yes
- Histopathology: Yes
OFFSPRING
- Time point of sacrifice of offspring selected for brain weight or neuropathological evaluation: postnatal day 22
- Description of postmortem examinations:
- At postnatal day 22 one male and one female per group were selected for brain weight measurements
- The brains from these pups/sex/group were immersion fixed and embedded in paraffin, blocked, sectioned, and stained with hematoxylin and eosin.
- Histopathological examination was performed on tissues from control and high-dose pups.
- On postnatal day 4, pups that were culled were euthanized and necropsied.
- On postnatal day 68, the remaining animals were necropsied. - Other examinations:
- None
- Positive control:
- No postive control was used
- Statistics:
- A combination of categorical, analysis of variance, survival time, and repeated measures techniques were used.
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Behaviour (functional findings):
- no effects observed
- Gross pathological findings:
- no effects observed
- Neuropathological findings:
- no effects observed
- Other effects:
- no effects observed
- Description (incidence and severity):
- Migrated information from 'Further observations for developmental neurotoxicity study'
Details on results (for developmental neurotoxicity):OTHER FINDINGS
- no significant findings in the motor activity test, startle test, and the active avoidance test. (migrated information) - Details on results:
- One maternal animal died in the 1200 dose group on post natal day 15.
The mean food consumption of females in the 700 dose group was significantly increased but only on post natal days 0-3. - Dose descriptor:
- NOAEL
- Effect level:
- 700 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: based on the death of 1 animal in the high-dose group
- Remarks on result:
- other: Generation: maternal (migrated information)
- Dose descriptor:
- NOAEL
- Effect level:
- 1 200 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: No adverse effects
- Remarks on result:
- other: Generation: offspring (migrated information)
- Conclusions:
- NOEL Maternal Toxicity = 700 mg/kg bw/day
There was no evidence of developmental neurotoxicity associated with isopropanol exposure as high as 1200 mg/kg/day (NOEL Developmental Neurotoxicity = 1200 mg/kg bw/day) .
Propan-2-ol (Isopropyl alcohol) as a main constituent of IPETC/ O-isopropyl ethylthiocarbamate and need to be considered in the assessment of IPETC/ O-isopropyl ethylthiocarbamate .
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 30 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- For dermal exposure we taken that:
-the average weight of rats is 250g (200-300g),
-the dose is applied over an area which is approximately 10% of the total body surface=0.025 kg
corrected dermal NOAEL= oral NOAEL
1200 mg/kg bw/day x 0.025 kg =
NOAELrat = 30 mg/kg bw/day
Additional information
Oral exposure:
There was no evidence of developmental neurotoxicity associated with isopropanol exposure as high as 1200 mg/kg/day (NOEL Developmental Neurotoxicity = 1200 mg/kg bw/day) .Propan-2-ol (Isopropyl alcohol) as a main constituent of IPETC/O-isopropyl ethylthiocarbamate and need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate.
Inhalation exposure:
The oral dose for the rat is converted to the corresponding air concentration using a standard breathing volume for the rat (1.15m3/kg for 24 hours exposure. The resulting air concentration needs to be additionally corrected for 24 hlight activity (20 m3), assuming 100 % absorption for both routes.
NOAEL rat 1200 mg/kg bw/day
÷1.15m3/kgbw
÷20m3/rat
NOAECrat 52.17 mg/m3
Dermal exposure:
For dermal exposure we taken that:
-the average weight of rats is 250g (200-300g),
-the dose is applied over an area which is approximately 10% of the total body surface=0.025 kg
corrected dermal NOAEL= oral NOAEL
1200 mg/kg bw/day x 0.025 kg =
NOAELrat = 30 mg/kg bw/day
Justification for classification or non-classification
There are conclusive but not suffcient data for the classification of substance IPETC/O-isopropyl ethylthiocarbamate with regard to Neurotoxicity.
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