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Diss Factsheets
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EC number: 200-268-0 | CAS number: 56-35-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 20 July 1970
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The skin of the back, sides and abdomen of the rats were shaved. The compound (TBTO) was sprayed on a skin area averaging 3.8 x 10 cm, usin a Deska compressed air vaporizer and covered with a plastic film and adhesive plaster (Tesaband). After 24 hours the plastic film was removed, the application site washed with luke-warm tap water. The application area was examined again after 4 hours and there after once daily for 8 days.
- GLP compliance:
- no
- Remarks:
- Completed before GLP standards, but would have been GLP compliant
- Limit test:
- no
Test material
- Reference substance name:
- Hexabutyl di-stannoxane
- IUPAC Name:
- Hexabutyl di-stannoxane
- Reference substance name:
- 21955
- IUPAC Name:
- 21955
- Details on test material:
- Not available
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 88-115 g
- Housing: Caged, Macrolon type II with wire-mesh bottom
- Diet (e.g. ad libitum): Altromin R, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: 13 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22-24 °C
- Humidity (%): 51-56%
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Back and abdomen
- % coverage: 3.8 x 10 cm area
- Type of wrap if used: plastic film and adhesive plaster
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Washed with luke-warm tap water
- Time after start of exposure: 24 hours
TEST MATERIAL
- Concentration (if solution): 10 g in 100 g
- Constant volume or concentration used: yes
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.5 carboxylmethyl cellulose, aq dest ad 100 mL - Duration of exposure:
- 24 hours
- Doses:
- One dose = 300 mg/kg
- No. of animals per sex per dose:
- 10 male & 10 female
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 9 days
- Frequency of observations and weighing: once per day
- Necropsy of survivors performed: yes
The following body areas, apertures, cavities and organs were examined by inspection and/or palpation, using appropriate equipment (e.g., hand-lens, stereoscopic microscope, instruments) in the course of assessing the nutritional state and cause of death, in all animals:
(1) Hairy pelt and
(2) Skin
Bodily apertures
(3) Eyes and conjunctiva
(4) Nose
(5) Mouth
(6) Ears
(7) Anus
(8) Preputial aperture
(9) Vulva
(10) Subcut. conn. tissue
(11) Abdominal and
(12) Pelvic cavities and
(13) Peritoneum
(14) Oesophagus*
(15) Stomach
(16) Small intestine
(17) Large intestine
(18) Mesenteric lymph node
(19) Liver
(20) Pancreas
(21) Spleen
(22) Kidneys
(23) Urinary bladder
(24) Seminal vesicles
(25) Prostate
(26) Testes
(27) Epididymides
(28) Ovaries
(29) Uterus
(30) Vagina*
(31) Thoracic cavity and
(32) Pleura
(33) Heart
(34) Lungs
(35) Trachea
(36) Thymus
(37) Cerebrum*
(38) Middle ear
(39) Site of administration
* Only where there is suspicion of pathological change as a result of the toxicity pattern, or other Special pathological findings.
Only pathological changes are recorded, with a note of their localisation, size or quantity, colour, surface area, section surface, consistency and/or diagnosis, in all animals, sub-divided in dose-groups - Statistics:
- No information
Results and discussion
- Preliminary study:
- No information
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 300 mg/kg bw
- Mortality:
- None
- Clinical signs:
- other: Apathy began a few hours after application and persisted to the 4th day. From day 5 onwards, erythema and swelling were observed at the application site. All animals survived a dose of approximately 300 mg/kg. Dry necrosis of the skin was found at the app
- Gross pathology:
- On male had dry necrosis of skin of back at site of application. Two females had reddish scabbed areas up to the size of a five-penny piece on the ventral skin. Two females had hard and dry ventral skin.
Applicant's summary and conclusion
- Conclusions:
- LD50 (epidermal) > 300 mg/kg
- Executive summary:
The skin of the back sides and abdomen of the rats was shaved. The compound (ZK 21,955 was sprayed on a skin area averaging 3.8 x 10 cm, using a Desaka compressed air vaporizer, and covered with a plastic film and adhesive plaster (Tesaband). A single application at a dose level of 300 mg/kg was applied. After 24 hours, the plastic film was removed, the application site was washed with luke-warm tap water. The application area was examined again after 4 hours and thereafter once daily until day 8. Apathy began a few hours after application and persisted to the 4th day. From day 5 onwards, erythema and swelling were observed at the application site. All animals survived a dose of approximately 300 mg/kg. Dry necrosis of the skin was found at the application site.
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