Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-058-1 | CAS number: 77-78-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessement.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
- Principles of method if other than guideline:
- Method: other: BASF-Test
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Dimethyl sulphate
- EC Number:
- 201-058-1
- EC Name:
- Dimethyl sulphate
- Cas Number:
- 77-78-1
- Molecular formula:
- C2H6O4S
- IUPAC Name:
- dimethyl sulfate
- Details on test material:
- - Name of test material (as cited in study report): dimethyl sulphate
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: US
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: US rats
- Age at study initiation: young adult animals were used
- Diet: ad libitum
- Water: ad libitum
- Acclimation period:
ENVIRONMENTAL CONDITIONS
no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: tragacanth (polysaccharide)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: animals received emulsions of 0.5-20% test substance with tragacanth by oral gavage
- Amount of vehicle (if gavage): 25-1600 µl/kg bw - Doses:
- 25, 50, 64, 80, 100, 125, 200 and 1600 µl/kg body weight (corresponding to appr. 33.3, 66.5, 85.1, 106.4, 133.0, 166.3, 266.0 and 2128.0 mg/kg body weight assuming a density of 1.33 g/ml)
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: animals were observed and examined for clinical signs of toxicity at least daily
- Necropsy of survivors performed: yes; deceased animals and those sacrificed at the end of the observation period were necropsied
- Other examinations performed: clinical signs, body weight - Statistics:
- LD50 was approximated
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 85.1 - < 133 mg/kg bw
- Remarks on result:
- other: 20/20 animals died in the 133.0 mg/kg body weight dose group, 9/20 (8 males) died in the 106.4 mg/kg body weight dose group and 3/20 (2 males) died in the 133.0 mg/kg body weight dose group.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 106.4
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 85.1 - < 106.4
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 106.4 - < 133.2
- Mortality:
- First deaths were noted 1 h after dosing. All deaths occurred within 24 hours (see Table 1). No deaths occurred in the 50 µl/kg-group within the 7-day observation period.
- Clinical signs:
- Restlessness, irregular and accelerated breathing was reported for all dose levels. Dyspnoe, convulsions, apathy, hunched posture was observed at 100 µl/kg and higher doses.
- Gross pathology:
- Section findings, not discriminated according to dose level: Gastrectasy, decomposition, terminal lung oedema.
Any other information on results incl. tables
Table 1: Mortality
Dose level (µl/kg bw) |
Mortality during the 7-day observation period |
||
Males |
Females |
Total |
|
1600 |
10/10 |
10/10 |
20/20 |
200 |
10/10 |
10/10 |
20/20 |
125 |
6/10 |
10/10 |
16/20 |
100 |
10/10 |
10/10 |
20/20 |
80 |
1/10 |
8/10 |
9/20 |
64 |
1/10 |
2/10 |
3/20 |
50 |
0/10 |
0/10 |
0/20 |
25 |
0/10 |
0/10 |
0/20 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)