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Diss Factsheets
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EC number: 204-667-0 | CAS number: 123-96-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 November 2009 to 09 November 2009
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to GLP in accordance with generally accepted scientific principles, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of the relevant results.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- EPISKIN(TM) reconstituted human epidermis model.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Octan-2-ol
- EC Number:
- 204-667-0
- EC Name:
- Octan-2-ol
- Cas Number:
- 123-96-6
- Molecular formula:
- C8H18O
- IUPAC Name:
- octan-2-ol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- other: reconstituted human epidermis
- Strain:
- other: not applicable
- Details on test animals or test system and environmental conditions:
- Not applicable as the test was performed in vitro.
Test system
- Type of coverage:
- other: test material applied directly
- Preparation of test site:
- other: not applicable
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: not applicable
- Amount / concentration applied:
- 10 µl of the test material was applied to the epidermis surface.
- Duration of treatment / exposure:
- 15 minutes
- Observation period:
- Not applicable
- Number of animals:
- The test was conducted In Vitro. Three replicate test tissues were used for the main test.
- Details on study design:
- TEST SITE
- Area of exposure: Whole of test tissue surface
- % coverage: 100%
- Type of wrap if used: Not applicable
REMOVAL OF TEST SUBSTANCE
- Washing (if done): At the end of the exposure period, each tissue was removed from the well of the treatment plate using forceps and rinsed using a wash bottle containing Phosphate Buffered Saline Dulbeccos (PBS) with Ca++ and Mg++. Rinsing was achieved by filling and emptying each tissue insert for approximately 40 seconds using a constant soft stream of PBS to gently remove any residual test material.
- Time after start of exposure: 15 ± 0.5 minutes.
SCORING SYSTEM: Not applicable
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: other: relative mean viability of the test material treated tissues
- Value:
- 87.8
- Remarks on result:
- other:
- Remarks:
- Basis: mean. Time point: 15 minutes. Remarks: Score is in % terms. (migrated information)
Any other information on results incl. tables
For the test material the relative mean tissue viabilities obtained after the 15 minute treatment followed by the 42 hour post-exposure incubation period were compared to the mean of the negative control treated tissues (n=3). The relative mean viabilities were calculated in the following way:
Classification of irritation potential is based upon relative tissue viability following the 15 minute exposure period followed by the 42 hour post-exposure incubation period according to the following table:
Criteria for in vitro interpretation |
Classification |
Mean tissue viability is =50% |
Irritant (I) R38 |
Mean tissue viability is >50% |
Non-Irritant (NI) |
Mean OD540Values and Percentage Viabilities for the Negative Control Material, Positive Control Material and Test Material
Material |
OD540of tissues |
Mean OD540of triplicate tissues |
±SDof OD540 |
Relative individual tissue viability (%) |
Relative mean viability (%) |
± SD of % viability |
Negative Control Material |
0.932 |
0.879 |
0.053 |
106.0 |
100* |
6.0 |
0.878 |
99.9 |
|||||
0.826 |
94.0 |
|||||
Positive Control Material |
0.064 |
0.068 |
0.030 |
7.3 |
7.8 |
3.4 |
0.100 |
11.4 |
|||||
0.041 |
4.7 |
|||||
Test Material |
0.851 |
0.772 |
0.088 |
96.8 |
87.8 |
10.0 |
0.678 |
77.1 |
|||||
0.788 |
89.6 |
SD= Standard deviation
*= The mean viability of the negative control tissues is set at 100%
The relative mean viability of the test material treated tissues was 87.8% after a 15 minute exposure.
The MTT solution containing the test material did not turn blue/purple which indicated that the test material did not directly reduce MTT.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: As specified in the test method.
- Conclusions:
- The test material was considered to be Non-Irritant.
- Executive summary:
The substance has been found to be non-irritating to skin in an in vitro test using the EPISKINTMreconstituted human epidermis model.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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