Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-679-9 | CAS number: 2215-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979/12/12-1980/01/29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This non-GLP study was not conducted under OECD 401, however the reported data are similar enough not to warrant restriction.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: 16CFR1500.3
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- Quality Assurance signed and inspection dated 1980/02/11
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Zinc O,O,O',O'-tetrakis(1,3-dimethylbutyl) bis(phosphorodithioate)
- EC Number:
- 218-679-9
- EC Name:
- Zinc O,O,O',O'-tetrakis(1,3-dimethylbutyl) bis(phosphorodithioate)
- Cas Number:
- 2215-35-2
- Molecular formula:
- Too complex
- IUPAC Name:
- zinc O,O,O',O'-tetrakis(1,3-dimethylbutyl) bis(phosphorodithioate)
- Details on test material:
- Sample was received at the laboratory on 1979/10/04 and described as a brown liquid with specific gravity of 1.1.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 45 male and 5 female Wistar rats, at least 8 weeks old when received and between 220 and 300 g, were supplied by Ace Animals and equilibrated for at least one week in the laboratory. Apparently healthy rats were selected for the test. The animals were identified by cage tags noting test material, start date, animal number and sex. Each animal was identified by an indelible body mark. Animals were housed 5/cage in suspended wire mesh cages and were provided fresh Purina rat chow and water ad libitum except for 16-20 h prior to dosing when food was removed. The animal room was maintained at 20-21°C and was kept clean in accordance with AAALAC standards.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- The test material was given orally by gavage. One group of 10 male rats was dosed at 5.0 g/kg initially. Based on the results of the initial dose, four additional groups of 10 male rats were dosed at various levels in order to determine the LD 50 of the test material. The dose was based on the sample weight as calculated from specific gravity. The vehicle, if any, was chosen because of its lack of known toxicity, lack of physiological effect and because it is relatively unreactive with other chemical substances.
- Doses:
- 0.6, 1.22, 1.73, 2.47 and 5.0 g/kg
- No. of animals per sex per dose:
- 10 males per dose except at 5.0 g/kg where 5 males and 5 females were dosed.
- Control animals:
- no
- Details on study design:
- Rats were observed 3-4 h after dosing and once daily for 14 days. Mortality, toxicity and pharmacological effects were recorded. Body weights were recorded pretest and in survivors at 14 days. At 14 days, all survivors were sacrificed. All animals were examined for gross pathology.
- Statistics:
- LD 50 was calculated according to the method of Litchfield, J.T. Jr. and F. Wilcoxon, 1949.
Results and discussion
- Preliminary study:
- A preliminary study was conducted in male rats at 10 g/kg, however no details about the results are provided in the report.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 230 mg/kg bw
- 95% CL:
- >= 1.66 - <= 2.99
- Mortality:
- No mortalities occurred following administration of 0.6 g/kg. 1/10 animals died at the dose level of 1.22 g/kg, 3/10 at 1.73 g/kg, and 10/10 at 2.47 g/kg and 5.0 g/kg.
- Clinical signs:
- other: Generally, lethargy, diarrhea, piloerection and ptosis occurred 3-4 h post dose and occasionally later, at all doses. At 5.0 g/kg, diarrhoea was the only toxic sign at 3-4 h post dose.
- Gross pathology:
- Necropsy observations included lung and gastrointestinal abnormalities.
- Other findings:
- No other findings reported.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Under the conditions of this study, the test material is toxic as defined in 16 CFR 1500.3 in male and female Wistar rats.
- Executive summary:
In an acute oral toxicity study, male and female Wistar rats were exposed to the test substance at doses of 0.6, 1.22, 1.73, 2.47 and 5.0 g/kg. The oral LD50 is 2.23 g/kg. Sublethal effects of lethargy, diarrhea, piloerection and ptosis were observed in all groups. Necropsy observations included lung and gastrointestinal abnormalities. Based on the results of this study, this test substance would be classified as Category 5 in accordance with the classification system of GHS. This toxicity study is classified as acceptable and satisfies the guideline requirement for acute oral toxicity in rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)