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EC number: 204-846-3 | CAS number: 127-51-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- data is from experimental reports following standard procedures
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To determine the ocular irritation potential of the test chemical im rabbits.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one
- EC Number:
- 204-846-3
- EC Name:
- 3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one
- Cas Number:
- 127-51-5
- Molecular formula:
- C14H22O
- IUPAC Name:
- 3-methyl-4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one
- Test material form:
- liquid
- Details on test material:
- - Name of test material : 3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one
- Common name : alpha-isomethyl ionone
- Molecular formula : C14H22O
- Molecular weight : 206.327 g/mol
- Smiles notation : C1([C@@H](\C=C(\C(C)=O)C)C(=CCC1)C)(C)C
- InChl : 1S/C14H22O/c1-10-7-6-8-14(4,5)13(10)9-11(2)12(3)15/h7,9,13H,6,8H2,1-5H3/b11-9+
- Substance type : Organic
- Physical state : Liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the left eye acted as control
- Amount / concentration applied:
- 0.1 ml of the test sample was instilled into the right eye of the rabbits
- Duration of treatment / exposure:
- 7 days
- Observation period (in vivo):
- The rabbits were examined every 24 hours for four days and then again on the 7th day.
- Duration of post- treatment incubation (in vitro):
- No data available
- Number of animals or in vitro replicates:
- 3 healthy, normal albino rabbits were used for the study.
- Details on study design:
- Scoring System: The scorings were made according to the Draize scale for scoring of ocular lesions.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 80
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 10
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 14
- Max. score:
- 20
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- no indication of irritation
- Remarks:
- The score is the mean of conjunctivae redness, chemosis and conjunctivae discharge.
- Irritant / corrosive response data:
- The score is the mean of conjunctivae redness, chemosis and conjunctivae discharge.
- Other effects:
- No data available
Any other information on results incl. tables
Results of the Individual animals after instillation of the test chemical
Rabbit 1
Area of the eye involved |
Results |
||||
1 day |
2 days |
3 days |
4 days |
7 days |
|
Cornea |
|
|
|
|
|
A. Opacity |
0 |
0 |
0 |
0 |
0 |
B. Area of cornea involved |
0 |
0 |
0 |
0 |
0 |
Total = A*B*5 (maximum = 80) |
0*0*5 = 0 |
||||
Iris |
|
|
|
|
|
A. Values |
0 |
0 |
0 |
0 |
0 |
Total = A*5 (maximum = 10) |
0*5=0 |
||||
Conjunctivae |
|
|
|
|
|
A. Redness |
3 |
2 |
2 |
2 |
0 |
B. Chemosis |
2 |
2 |
1 |
1 |
0 |
C. Discharge |
2 |
1 |
1 |
0 |
0 |
Score = (A+B+C)*2 (maximum = 20) |
(3+2+2)*2 = 14 |
Rabbit 2
Area of the eye involved |
Results |
||||||
1 day |
2 days |
3 days |
4 days |
7 days |
|||
Cornea |
|
|
|
|
|
||
A. Opacity |
0 |
0 |
0 |
0 |
0 |
||
B. Area of cornea involved |
0 |
0 |
0 |
0 |
0 |
||
Total = A*B*5 (maximum = 80) |
0*0*5 = 0 |
||||||
Iris |
|
|
|
|
|
||
A. Values |
0 |
0 |
0 |
0 |
0 |
||
Total = A*5 (maximum = 10) |
0*5=0 |
||||||
Conjunctivae |
|
|
|
|
|
||
A. Redness |
3 |
2 |
2 |
2 |
0 |
||
B. Chemosis |
2 |
2 |
1 |
1 |
0 |
||
C. Discharge |
2 |
1 |
0 |
0 |
0 |
||
Score = (A+B+C)*2 (maximum = 20) |
(3+2+2)*2 = 14 |
||||||
Rabbit 3
Area of the eye involved |
Results |
||||||
1 day |
2 days |
3 days |
4 days |
7 days |
|||
Cornea |
|
|
|
|
|
||
A. Opacity |
0 |
0 |
0 |
0 |
0 |
||
B. Area of cornea involved |
0 |
0 |
0 |
0 |
0 |
||
Total = A*B*5 (maximum = 80) |
0*0*5 = 0 |
||||||
Iris |
|
|
|
|
|
||
A. Values |
0 |
0 |
0 |
0 |
0 |
||
Total = A*5 (maximum = 10) |
0*5=0 |
||||||
Conjunctivae |
|
|
|
|
|
||
A. Redness |
3 |
2 |
2 |
2 |
0 |
||
B. Chemosis |
2 |
2 |
1 |
1 |
0 |
||
C. Discharge |
2 |
1 |
1 |
0 |
0 |
||
Score = (A+B+C)*2 (maximum = 20) |
(3+2+2)*2 = 14 |
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- Instillation of the test chemical did not produce any corneal opacity or iris congestion, while an intense conjunctival irritation occurred involving chemosis and discharge.On the seventh day of discharge the treated eyes were normal. Based on these observations,the test chemical can be considered to be not irritating to rabbit eyes.
- Executive summary:
In an eye irritation study, the toxic effects of the test chemical was investigated to see if it produced any irritation when instilled into eyes of rabbits. 0.1 ml of the test sample was instilled into the right eye of 3 healthy, normal albino rabbits. The rabbits were examined every 24 hours for four days and then again on the 7th day. The left eye acted as control. The scorings were made according to the Draize scale for scoring of ocular lesions. As seen by the results, instillation of the test chemical did not produce any corneal opacity or iris congestion. However, an intense conjunctival irritation did occur, involving chemosis and discharge. On the seventh day of discharge, the treated eyes were normal. Therefore, the test chemical can be considered to be not irritating to rabbit eyes.
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