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EC number: 202-700-3 | CAS number: 98-79-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The experimental work associated with this study was carried out between 11 November 2016 and 22 March 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- Test substances: (2S)-5-oxopyrrolidine-2-carboxylic acid Technical Materials
Acid Source: (2S)-5-oxopyrrolidine-2-carboxylic acid (Acid Source)
Salt Source: (2S)-5-oxopyrrolidine-2-carboxylic acid (Potassium Salt)
Received on: 8th November 2016
DNAL Sample Numbers: DNA3730/1-2
Reference Standard: (S)-(-)-2-Pyrrolidinone-5-carboxylic acid reference standard
Received on: 6th January 2017 - Key result
- Water solubility:
- ca. 520.6 g/L
- Temp.:
- 20 °C
- pH:
- ca. 4
- Key result
- Water solubility:
- ca. 549.9 g/L
- Temp.:
- 20 °C
- pH:
- ca. 7
- Key result
- Water solubility:
- ca. 517.9 g/L
- Temp.:
- 20 °C
- pH:
- ca. 9
- Conclusions:
- No significant deviation was recorded in this part of the study.
According to the results obtained in this test the overall mean water solubility is: 520.6g/L (pH4 at 20 deg C)
According to the results obtained in this test the overall mean water solubility is: 549.9g/L (pH7 at 20 deg C)
According to the results obtained in this test the overall mean water solubility is: 517.9g/L (pH9 at 20 deg C)
Reference
Solubility in pH 4 Water at 20 deg C Results
Only saturated samples of the reference substance were used to calculate the overall mean saturation concentration (g/L).
Description | Raw Data File | Retention Time (minutes) | Unit Area | Response Factor | Concentration (mg/L) | Concentration (g/L) | Sample Comments |
0.25mg/mL L-PCA | L1603S14 | 5.12 | 2020.9 | 0.000123 | |||
L-PCA Ref Standard pH4 Low 24hr | L1603W1 | 5.07 | 3468.2 | 0.4267 | 426.7 | Unsaturated | |
L-PCA Ref Standard pH4 Low 48hr | L1603W2 | 5.06 | 3468.7 | 0.4268 | 426.8 | Unsaturated | |
L-PCA Ref Standard pH4 Low 72hr | L1603W3 | 5.06 | 3533.2 | 0.4347 | 434.7 | Unsaturated | |
0.25mg/mL L-PCA | L1603S15 | 5.12 | 2043.0 | Mean of 3 results: | 429.4 | ||
0.5mg/mL L-PCA | L1603S18 | 5.05 | 3832.4 | 0.000132 | |||
L-PCA Ref Standard pH4 Low 24hr | L1603W10 | 5.04 | 3794.8 | 0.4992 | 499.2 | Saturated | |
L-PCA Ref Standard pH4 Low 48hr | L1603W11 | 5.00 | 3841.5 | 0.5054 | 505.4 | Saturated | |
L-PCA Ref Standard pH4 Low 72hr | L1603W12 | 5.01 | 3966.5 | 0.5218 | 521.8 | Saturated | |
0.5mg/mL L-PCA | L1603S19 | 5.02 | 3769.0 | Mean of three results: | 508.8 | ||
0.5mg/mL L-PCA | L1603S21 | 5.01 | 3967.2 | 0.000126 | |||
L-PCA Ref Standard pH4 Low 24hr | L1603W19 | 4.99 | 4384.4 | 0.5546 | 554.6 | Saturated | |
L-PCA Ref Standard pH4 Low 48hr | L1603W20 | 4.99 | 4315.2 | 0.5548 | 554.8 | Saturated | |
L-PCA Ref Standard pH4 Low 72hr | L1603W21 | 5.00 | 3928.5 | 0.4969 | 496.9 | Saturated | |
0.5mg/mL L-PCA | L1603S22 | 5.00 | 3938.5 | Mean of three results: | 532.5 | ||
Overall mean saturation: | 520.6 |
Solubility in pH 7 Water at 20 deg C Results
Only saturated samples of the reference substance were used to calculate the overall mean saturation concentration (g/L).
Description | Raw Data File | Retention time (minutes) | Unit Area | Response Factor | Concentration (mg/mL) | Concentration (g/L) | Sample Comments |
0.25mg/mL L-PCA | L1603S15 | 5.12 | 2043.0 | 0.000123 | |||
L-PCA Ref Standard pH7 Low 24hr | L1603W4 | 5.06 | 3517.0 | 0.4318 | 431.8 | Unsaturated | |
L-PCA Ref Standard pH7 Low 48hr | L1603W5 | 5.06 | 3570.8 | 0.4384 | 438.4 | Unsaturated | |
L-PCA Ref Standard pH7 Low 72hr | L1603W6 | 5.05 | 3664.1 | 0.4499 | 449.9 | Unsaturated | |
0.25mg/mL L-PCA | L1603S16 | 5.11 | 2029.2 | Mean of three results: | 440.1 | ||
0.50mg/mL L-PCA | L1603S19 | 5.02 | 3769.0 | 0.000130 | |||
L-PCA Ref Standard pH7 Low 24hr | L1603W13 | 5.00 | 4135.4 | 0.5372 | 537.2 | Saturated | |
L-PCA Ref Standard pH7 Low 48hr | L1603W14 | 5.00 | 4164.0 | 0.5409 | 540.9 | Saturated | |
L-PCA Ref Standard pH7 Low 72hr | L1603W15 | 5.01 | 4063.5 | 0.5279 | 527.9 | Saturated | |
0.50mg/mL L-PCA | L1603S20 | 5.01 | 3928.9 | Mean of three results: | 535.3 | ||
0.50mg/mL L-PCA | L1603S22 | 5.00 | 3938.5 | 0.000127 | |||
L-PCA Ref Standard pH7 Low 24hr | L1603W22 | 4.98 | 4536.3 | 0.5762 | 576.2 | Saturation | |
L-PCA Ref Standard pH7 Low 48hr | L1603W23 | 4.98 | 4486.8 | 0.5699 | 569.9 | Saturation | |
L-PCA Ref Standard pH7 Low 72hr | L1603W24 | 4.99 | 4310.8 | 0.5475 | 547.5 | Saturation | |
0.50mg/mL L-PCA | L1603S23 | 5.00 | 3934.7 | Mean of three results: | 564.5 | ||
Overall mean saturation: | 549.9 |
Solubility in pH 9 Water at 20 deg C Results
Only saturated samples of the reference substance were used to calculate the overall mean saturation concentration (g/L).
Description | Raw Data File | Retention time (minutes) | Unit Area | Response Factor | Concentration (mg/mL) | Concentration (g/L) | Sample Comments |
0.25mg/mL L-PCA | L1603S16 | 5.11 | 2029.2 | 0.000124 | |||
L-PCA Ref Standard pH9 Low 24hr | L1603W7 | 5.06 | 3428.4 | 0.4259 | 425.9 | Unsaturated | |
L-PCA Ref Standard pH9 Low 48hr | L1603W8 | 5.05 | 3499.0 | 0.4347 | 434.7 | Unsaturated | |
L-PCA Ref Standard pH9 Low 72hr | L1603W9 | 5.06 | 3315.8 | 0.4119 | 411.9 | Unsaturated | |
0.25mg/mL L-PCA | L1603S17 | 5.11 | 1995.5 | Mean of three results: | 424.2 | ||
0.50mg/mL L-PCA | L1603S19 | 5.02 | 3769.0 | 0.000130 | |||
L-PCA Ref Standard pH9 Low 24hr | L1603W13 | 5.00 | 4135.4 | 0.5372 | 521.5 | Saturated | |
L-PCA Ref Standard pH9 Low 48hr | L1603W14 | 5.00 | 4164.0 | 0.5409 | 498.3 | Saturated | |
L-PCA Ref Standard pH9 Low 72hr | L1603W15 | 5.01 | 4063.5 | 0.5279 | 531.0 | Saturated | |
0.50mg/mL L-PCA | L1603W20 | 5.01 | 3928.9 | Mean of three results: | 516.9 | ||
0.50mg/mL L-PCA | L1603W23 | 5.00 | 3934.7 | 0.000126 | |||
L-PCA Ref Standard pH9 Low 24hr | L1603W25 | 4.98 | 4427.2 | 0.5629 | 562.9 | Saturated | |
L-PCA Ref Standard pH9 Low 48hr | L1603W26 | 5.00 | 3867.9 | 0.4918 | 491.8 | Saturated | |
L-PCA Ref Standard pH9 Low 72hr | L1603W27 | 5.00 | 3948.3 | 0.5020 | 502.0 | Saturated | |
0.50mg/mL L-PCA | L1603W24 | 5.01 | 3930.5 | Mean of three results: | 518.9 | ||
Overall mean saturation: | 517.9 |
Description of key information
The overall mean water solubility is: 520.6g/L (pH4 at 20 deg C), 549.9g/L (pH7 at 20 deg C), and 517.9g/L (pH9 at 20 deg C).
Key value for chemical safety assessment
- Water solubility:
- 549.9 g/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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