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EC number: 852-824-2 | CAS number: 1404220-73-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Triisodecyl phosphite (TDP) was test using the LLNA assay at concentrations of 25%, 50%, and 100%. It was positive at all test concentrations. The calculated EC3 value is 20.1%. The TDP results suggest that DP 374 should be classified as a skin sensitiser, 1B (i.e. not a strong skin sensitiser). In addition, hte
Local lymph node assay (LLNA) study of diisodecyl phenyl phosphite (Sanders 2010) showed positive responses at 50% and 100% concentrations. EC3 value was determined to be 40.6%
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Details on test animals and environmental conditions:
- The animals were acclimatised for a period of at least 5 days, after which animals were selected at random and given a unique number marked on their tail. At the start of the study the animals weighed in the range of 15 to 23 grams and were 8-12 weeks in age.
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 25%, 50%, 100%
- No. of animals per dose:
- 4
- Details on study design:
- Five days following the first topical applications, all mice were injected via the tail vein with 250 uL of phosphate buffered saline (PBS) containing 3H-methyl thymidine (3HTdR) giving a total of 20 uCi to each mouse.
- Statistics:
- EC3= 20%; based on a regression analysis of the dose groups. All dose groups were positive, but there was sufficient dose-response to determine an EC3.
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: vehicle 14023.98 25% 53667.32 50% 103195.40 100% 137149.20
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Test substance was postive (ratio >3) at concentrations of 25, 50, and 100%. An EC3 was determined to be 20%. The results indicated that TDP is a skin sensitiser, but not a strong skin sensitiser.
- Executive summary:
TDP was test using the LLNA assay at concentrations of 25%, 50%, and 100%. It was positive at all test concentrations. The calculated EC3 value is 20.1%. The results suggest that TDP should be classified as a skin sensitiser, but not a strong skin sensitiser.
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP, guideline study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
- Species:
- mouse
- Strain:
- other: CBA/Ca
- Sex:
- female
- Details on test animals and environmental conditions:
- CBA/Ca female mice, nulliparious and non-pregnant. 5 day acclimatisation peroiod. At the start of the study the animals were 8-12 weeks old.
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 0, 25, 50, 100%
- No. of animals per dose:
- 4
- Details on study design:
- A preliminary screening test was done to ascertain the systemic toxicity/irritancy potential of the test material. Based on these results, the top dose was set at 100% (neat material), followed by lower doses at 25% and 50% dilutions in an acetone/olive oil (4:1) mixture.
- Parameter:
- SI
- Value:
- 2.34
- Test group / Remarks:
- 25% concentration
- Parameter:
- SI
- Value:
- 3.4
- Test group / Remarks:
- 50% concentration
- Parameter:
- SI
- Value:
- 6.3
- Test group / Remarks:
- 100% concentration
- Parameter:
- EC3
- Value:
- 0.406
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: 0% (Vehicle) - 1399.81 25% - 3270.49 50% - 4763.82 100% - 8825.35
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Conclusions:
- Weston PDDP was sensitising at concentrations of 50% and 100%. The EC3 value is 40.6% from this study.
- Executive summary:
While this study indicated that Weston PDDP is a skin sensitiser, the relatively high EC3 value (40.6%) indicates that this substance is not a strong skin sensitiser.
Referenceopen allclose all
Concentration |
dpm/node |
Test / Control Ratio |
Vehicle (acetone/olive oil 4:1) |
1753.00 |
N/A |
25% |
6708.42 |
3.83 |
50% |
12899.43 |
7.36 |
100% |
17143.65 |
9.78 |
EC3= 20% |
Conc |
dpm/ node |
Test / Control Ratio |
Result |
Blank |
1399.81 |
N/A |
N/A |
25% |
3270.49 |
2.34 |
Negative |
50% |
4763.82 |
3.40 |
Positive |
100% |
8825.35 |
6.30 |
Positive |
EC3 value = 40.6% The draft report is in preparation. |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
Justification for classification or non-classification
Classified as a skin sensitizer based on the positive LLNA study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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