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EC number: 922-676-4 | CAS number: 286426-31-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-[(1S)-2-[benzyl(methyl)amino]-1-hydroxyethyl]phenol
- Cas Number:
- 286426-31-1
- Molecular formula:
- C17 H20 O2
- IUPAC Name:
- 3-[(1S)-2-[benzyl(methyl)amino]-1-hydroxyethyl]phenol
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Physical state: solid
- Analytical purity: 99.7 %
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Winkelmann GmbH , D-33178 Borchen
- Weight at study initiation: female 160 g -165 g and male 170 g- 180 g ( 3 female and 3 male animals were used )
- Fasting period before study: Animals were fasted by withholding food over night.
- Housing: The animals were individually kept in Macrolon cages on Altromin saw fiber bedding.
- Diet : Feeding ad libitium, Altromin 1324 maintenance diet for rats and mice, totally-pathogen-free-TPF
- Water : Free access to tap water ( drinking water, municipalresidue control, microbiol. controlled periodically )
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 -25
- Humidity (%): 45-65
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12:12, light 6.00-18.00
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2 g
- Amount of vehicle (if gavage): 8 ml
- Justification for choice of vehicle: The vehicle was chosen due to its non-toxic characteristics
MAXIMUM DOSE VOLUME APPLIED: 2000mg/kg body weight - Doses:
- 2000 mg/kg body weigth;
Since no presence of compound-related mortality of the anmials was observed no further testing was required. - No. of animals per sex per dose:
- 3 male and 3 female animals per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals wer weighted prior to first application and once a week thereafter.
- Necropsy of survivors performed: yes
- Other examinations performed: A careful clinical examinationwas made twiche a day on the day of dosing and once day thereafter. Cageside
observations included changes in the skin and fur, eyes and mucous membranes. Also respiratory, circulatory, autonomic and central nervous system and somatomotor activity and behaviour pattern were examined. Particular attention was directed to observation of tremor, convulsions,salivation,diarrhoea, lethargy,sleep and coma.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- The oral application of the test item in a dose of 2000 mg/kg BW caused no compound related mortalities.
Male: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 0 - Clinical signs:
- other: No clinical signs of toxicity were observed throughout the observation period.
- Gross pathology:
- Necropsy revelaed an acute injection of blood vessels in all animals in the abdominal region . This finding is due to euthanasia with an overdose of
pentobarbital injected intraperitoneally.
No other macroscopic necropsy findings were recorded.
Any other information on results incl. tables
Weight Gain
Animal Number / Sex | Day 0 | Day 7 | Day 14 |
1 male | 170 | 202 | 237 |
2 male | 178 | 200 | 245 |
3 male | 180 | 203 | 242 |
1 female | 160 | 172 | 188 |
2 female | 162 | 173 | 187 |
3 female | 165 | 182 | 196 |
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Considering the reported data of this toxicity test it can be stated that the test item L-Benzyladrianol Base has no acute toxic characteristics.
The LD50 was determined to be > 2000 mg/kg BW. - Executive summary:
The test item L-Benzyladrianol Base was given in a dose of 2000 mg/kg body weight to two groups of 3 male and 3 female rats
( HsdBrl: WH Wistar ) in a single exposure via oral gavage. A careful clinical examination was made once a day.
At the end of the observation period the animals were sacrified and necropsy was carried out to record gross pathological changes.
A maximum dosage of 2000 mg/kg BW according to the acute toxic class method regime, caused no compound related mortality
within 14 days p.appl.. No clinical signs of toxicity were observed throughout the oberservation period.
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