Registration Dossier
Registration Dossier
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EC number: 424-620-1 | CAS number: 13909-63-2 TUPH
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: data from ELINCS notification dossier approved by MSCA
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 92/69/EEC, B.1
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-phenyl-3-(p-toluenesulfonyl)urea
- EC Number:
- 424-620-1
- EC Name:
- 1-phenyl-3-(p-toluenesulfonyl)urea
- Cas Number:
- 13909-63-2
- Molecular formula:
- C14H14N2O3S
- IUPAC Name:
- 3-(4-methylbenzenesulfonyl)-1-phenylurea
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Administration / exposure
- Vehicle:
- other: arachis oil B.P.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 785 mg/kg bw
- Mortality:
- Male: 500 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 707 mg/kg bw; Number of animals: 5; Number of deaths: 1
Maie: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 500 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: Mortality was observed at the day of application till four days after application. Crouched positure , lethargy, ataxy and reduced breathing frequence (dereased respiratory rate) were in general seen till day 3
- Gross pathology:
- Effects on organs:
In the animals which were killed at the end of the study no effects were observed.
The animals which died during the study showed haemorrhagic and abnormal red lungs, dark liver and slight bleedings of the stomach mucosa.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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