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Diss Factsheets
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EC number: 218-336-3 | CAS number: 2123-24-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Respiratory sensitisation
Administrative data
- Endpoint:
- respiratory sensitisation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
- Principles of method if other than guideline:
- Sensitization reactions to Caprolactam aerosols were observed by exposing groups of 4 guinea pigs for 30 min/day for 5 consecutive days to 3 aerosol concentrations (3, 10 and 30 mg/m³ which corresponds to 0.003, 0.01 and 0.03 mg/l).
Each animal was placed in a whole body plethysmograph attached to a primary chamber. This device can detect pressure changes induced by the breathing activity of the test animals.
On days 19, 26, 33 and 40, all three groups of animals were challenged with CO2, then given a 30 minute challenge of 30 mg/m³ caprolactam and another CO2 challenge 45 min later. After the last challenge, lungs were removed from all animals and grossly examined. - GLP compliance:
- not specified
Test material
- Reference substance name:
- ε-caprolactam
- EC Number:
- 203-313-2
- EC Name:
- ε-caprolactam
- Cas Number:
- 105-60-2
- Molecular formula:
- C6H11NO
- IUPAC Name:
- azepan-2-one
- Details on test material:
- - Name of test material (as cited in study report): E-Caprolactam
- Physical state: white flakes
- Lot/batch No.: D344A441 from BASF Corp. Chemical Division, Freeport, Texas
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton Labs Inc., Denver, PA
- Weight at study initiation: 381-455 g
- Diet (e.g. ad libitum): Ralston Purina Guinea Pig Chow
- Water (e.g. ad libitum): Tap water
- Acclimation period: 12 days
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Route of induction exposure:
- inhalation
- Route of challenge exposure:
- inhalation
- Vehicle:
- water
- Concentration:
- 3, 10 and 30 mg/m³ which corresponds to 0.003, 0.01, and 0.03 mg/L
- No. of animals per dose:
- 4
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 5
- Exposure period: 30 min
- Each animal was placed in a whole body plethysmograph attached to a primary chamber. A sensitive differential pressure transducer (Gaeltec 8T-2) was attached to each whole body plethysmograph. With each breath, a pressure change (AP) was created in the whole body plethysmograph and detected by the transducer.
- A 15% solution of caprolactam was prepared in distilled water. The solution was placed in a 30 ml syringe with a 20g needle attached. The syringe was fitted into a Harvard (Model 975) compact syringe pump which was set to deliver at 0.7 ml/minute. It was connected to the aerosol generator. The aerosol generator was pressurized at 15 psi with dry air. An additional 10 L/min of dry air was introduced at the side port of the Y tube at the entrance of the primary chamber. Thus, dry particles of caprolactam were produced for inhalation by the animals. The various concentrations of caprolactam were obtained by varying the exhaust airflow of the primary chamber from 20 L/min to 70 L/min.
B. CHALLENGE EXPOSURE
- No. of exposures: 1
- Day(s) of challenge: On days 19, 26, 33 and 40
- Exposure period: 30 min
- All three groups of animals were challenged with CO2, then given a 30 minute challenge of 30 mg/m³ caprolactam and another CO2 challenge 45 minutes later.
Results and discussion
Any other information on results incl. tables
FIRST 5 DAYS OF CONSECUTIVE EXPOSURES:
no significant respiratory responses to the Caprolactam. Only one cough
was noted during the entire series of experiments. Therefore, there was
no evidence of any kind of acute irritating or bronchoconstricting
properties.
CHALLENGE DAYS:
no immediate reaction, no evidence of an immediate hypersensitivity
reaction and no abnormal respiratory responses to Caprolactam.
Ventilatory response to the CO2 challenges was normal.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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