Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-653-9 | CAS number: 98-29-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
In accordance with the screening criteria of the ECHA Guidance on information requirements and chemical safety assessment (Part C and Chapter R.11: PBT assessment):
4-TBC is not readily biodegradable but inherently biodegradable with more than 70% of degradation reached in less than 7 days including the log and lag phases (OECD 302B). In addition an abiotic degradation test (OECD 111) showed that 4-TBC was stable in freshwater at pH 4, but unstable at higher pHs 7 and 9, with half-lives of 6 days and < 3.5 days respectively, the underlining phenomenon seemed to be oxidation instead of hydrolysis; and no major degradation products (>10%) were likely to be produced. Therefore, it is considered that 4-TBC does not comply with the P and vP criteria, that is the compound should not be Persistent in the environment.
As 4-TBC presents a Log Kow ≤ 4.5 (Log Kow = 1.98), it is assumed that the affinity for the lipids of an organism is insufficient to exceed the B criterion (i.e. BCF value > 2000).
4-TBC is neither classified as carcinogenic (Cat. 1, H350 or Cat.2, H351), mutagenic (Cat. 1, H340 or Cat. 2, H341), or toxic to reproduction (Cat. 1, H360 or Cat. 2, H361), nor classified as STOT RE Cat.1, H372 or Cat.2, H373. In acute aquatic toxicity tests, theE/LC50 for fish, daphnids and algae are upper 0.1 mg/L. Furthermore, based on Log Kow ≤ 4.5 (Log Kow of 1.98) and inherent biodegradability, 4-TBC fulfils neither P criteria, nor B criteria. As a result, the PBT assessment can be stopped, the substance being presumably not T.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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