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Diss Factsheets
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EC number: 204-710-3 | CAS number: 124-70-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 250 mg/kg bw/day
Additional information
There are no reproductive toxicity data on dichloro(methyl)(vinyl)silane or its hydrolysis product, methyl(vinyl)silanediol, so good quality data for the related substance trimethoxyvinylsilane have been used to assess the reproductive toxicity of dichloro(methyl)(vinyl)silane.
Dichloro(methyl)(vinyl)silane hydrolyses rapidly in contact with water (half-life <1 minute at pH 7), generating HCl and methyl(vinyl)silanediol. Trimethoxy(vinyl)silane (CAS 2768 -02 -7) hydrolyses more slowly at pH 7 (half-life ca.0.2 hours), but under acidic conditions such as in the stomach following ingestion, much more rapid hydrolysis can be expected based on experience with other methoxysilanes. The relevant hydrolysis products are methanol and vinylsilanetriol. The silanol hydrolysis products for the registered substance and the surrogate substance are therefore similar in chemical structure, the only difference being the replacement of -CH3with an extra Si-OH group. Both have high water solubility and very low log Kow(log Kow-0.05 and -2.0, respectively). Acute oral toxicity data for other related silanols [e.g. dimethylsilanediol and methylsilanetriol (as the potassium salt)] indicate there are no significant toxicological differences between silanediol and silanetriol analogues. Data obtained via the oral route for trimethoxyvinylsilane are therefore considered appropriate for read-across to trichloro(methyl)(vinyl)silane.
Short description of key information:
There are no repeated dose toxicity data on dichloro(methyl)(vinyl)silane or its hydrolysis product, methyl(vinyl)silanediol, so good quality data for the related substance trimethoxyvinylsilane have been used to assess the reproductive toxicity of dichloro(methyl)(vinyl)silane.
In an oral OECD 422 study ( Hashima Labs, no date) in rats, trimethoxyvinylsilane was administered by gavage at doses up to 1000 mg/kg bw/day, and no effects on reproductive parameters were observed for males up to 1000 mg/kg. For females, a low number of oestrous cases was reported for the high dose groups.. The NOAEL was therefore 250 mg/kg bw/day for females.
Effects on developmental toxicity
Description of key information
There are no repeated dose toxicity data on dichloro(methyl)(vinyl)silane or its hydrolysis product, methyl(vinyl)silanediol, so good quality data for the related substance trimethoxyvinylsilane have been used to assess the developmental toxicity of dichloro(methyl)(vinyl)silane.
Exposure of pregnant CD® rats during organogenesis to trimethoxyvinylsilane by inhalation resulted in slight maternal toxicity at 100 and 300 ppm as evidenced by concentration-dependent reductions in gestational body weight gain (gd 6-9). There was evidence of slightly delayed development in fetuses from the 300 ppm group as indicated by delayed ossification in several skeletal districts. No exposure-related embryotoxicity or teratogenicity was observed in this study (BRRC, 1993). The observed variations are not considered toxicological, particularly in the presence of maternal toxicity, and therefore the NOAEC is 300 ppm (approx. 1730 mg/m3).
Effect on developmental toxicity: via inhalation route
- Dose descriptor:
- NOAEC
- 1 730 mg/m³
Additional information
There are no developmental toxicity data on dichloro(methyl)(vinyl)silane or its hydrolysis product, methyl(vinyl)silanediol, so good quality data for the related substance trimethoxy(vinyl)silane have been used to assess the developmental toxicity of dichloro(methyl)(vinyl)silane.
For the inhalation route, the hydrolysis rate of trimethoxy(viny)lsilane in the respiratory tract and lungs is unknown, but is likely to be slower than that of dichloro(methyl)(vinyl)silane. For dichloro(methyl)(vinyl)silane, the species absorbed following inhalation exposure are mainly hydrolysis products, whereas for trimethoxyvinylsilane, absorption of the parent substance may be more significant. Trimethoxyvinylsilane has a higher log Kowvalue (1.08) therefore the proportion of inhaled material which is systemically absorbed is likely to be greater than for dichloro(methyl)(vinyl)silane. Nevertheless, in the absence of other data, the inhalatory NOAEL for trimethoxy(vinyl)silane is considered to represent a reasonable worst-case for read-across to dichloro(methyl)(vinyl)silane.
The HPV SIAR for methanol concludes the following: " High concentrations of methanol may cause specific malformations in organogenesis in pre-natal development of rodents. In the rat, the NOAEL (inhalation for 7 hours per day) was determined to be 6.5 mg/l, based on observance of malformations as well as slight decreased body weights. This corresponds to a maternal methanol blood level of 1000 to 2170 mg/l". Therefore the variations observed when trimethoxyvinylsilane was inhaled are unlikely to be due to methanol.
Justification for classification or non-classification
The available data on read-across substance trimethoxyvinylsilane suggest that dichloro(methyl)(vinyl)silane does not require classification for effects on reproduction or development.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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