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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 201-126-0 | CAS number: 78-59-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies on the design of animal tests for the corrosiveness of industrial chemicals
- Author:
- Potokar M, Grundler OJ, Heusener A, Jung R, Mürmann P, Schöbel C, Suberg H and Zechel HJ
- Year:
- 1 985
- Bibliographic source:
- Food Chem. Toxicol. 23, 615-617
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,5,5-trimethylcyclohex-2-enone
- EC Number:
- 201-126-0
- EC Name:
- 3,5,5-trimethylcyclohex-2-enone
- Cas Number:
- 78-59-1
- Molecular formula:
- C9H14O
- IUPAC Name:
- 3,5,5-trimethylcyclohex-2-enone
- Details on test material:
- Test substance: Isophorone
- Source: Chemische Werke Hüls AG
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
- Strain: New Zealand
- Sex: male / female
- Source: various breeders
- Weight at study initiation: 2-4 kg
- Number of animals: 6 (male plus female)
Environmental conditions
- animals were kept in individual cages under standardized laboratory conditions
Test system
- Type of coverage:
- other: semiocclusive and occlusive
- Preparation of test site:
- other: shorn
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- undiluted, 0.5 ml per patch
- Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- Postexposure period: 7 days
- Number of animals:
- 6
- Details on study design:
- ADMINISTRATION/EXPOSURE
- Preparation of test substance: none
- Area of exposure: laterally; shorn 15-24 hours in advance; 3 cm x 3 cm gauze pads with test substance
- Two patches were applied (one occlusive, one semi-occlusive): air-permeable circular bandage (semi-occlusive),
air-tight plastic foil (occlusive)
- Total volume applied: 0.5 ml per patch (corresponds to ca. 1500 mg/kg bw)
- Postexposure period: 7 days
- Removal of test substance: each after 4 hours; rinsed with water and dried
EXAMINATIONS
- Scoring system: 5th Amendment to 67/548/EEC (1983)
- Examination time points: 1, 24, 48, 72 hours, and 7 days after removal
Results and discussion
In vivo
Results
- Irritation parameter:
- other: see remarks
- Remarks on result:
- other: the report does not mention the scores for edema and erythema; it gives only the classification for skin irritation according to EC Directive 67/548/EEC
- Irritant / corrosive response data:
- no data
- Other effects:
- No irritation was observed after occlusive and semi-occlusive application.
Any other information on results incl. tables
no futher remarks
Applicant's summary and conclusion
- Conclusions:
- Under the present test conditions, none of six rabbits exposed for 4 hours to 1500 mg isophorone per patch and animal (semiocclusive and
occlusive conditions) showed any test item-related changes at the examination time-points 60 minutes, 24, 48 and 72 hours after patch removal. - Executive summary:
The acute skin irritation properties of isophorone were estimated according to OECD Guideline 404. A dose of 1500 mg test item per animal was applied to the shorn, intact dorsal skin of 6 male and female rabbits under semiocclusive and occlusive conditions for 4 hours. After removal of the patches the treated skin areas were rinsed with water and dried. The results were assessed 1, 24, 48 and 72 hr after patch removal. Under the test conditions no significant irritancy to skin were observed. Therefore, isophorone is not irritating to skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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