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Diss Factsheets
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EC number: 262-872-0 | CAS number: 61617-00-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
ZMB2 and MB2: WAIVER: In accordance with REACH Annex IX, Section 9.3.2, Column 2, bioaccumulation testing need not be conducted if:the substance has a low potential for bioaccumulation. LANXESS (2018 - see Section 13.2 of IUCLID) clearly shows that 2H-Benzimidazole-2-thione, 1,3-dihydro-4(or 5)-methyl-, zinc salt (2:1) (ZMB2), i.e. the registered substance, exhibits its salt characteristic in aqueous solution, i.e., dissolving in water to 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione (MB2) and zinc ions in a matter of seconds. Therefore, the measured log Pow value for ZMB2 is not considered relevant for bioaccumulation assessment as it will never exist in the aquatic environment. Instead, the data presented for MB2 (log Pow = 0.3 - 0.4) is most relevant for bioaccumulation potential. The low partitioning behaviour of MB2 is consistent with a conclusion of low bioaccumulation potential, and therefore bioaccumulation testing with the registered substance is not considered necessary.
Desthio-MB2: Bioconcentration factor (BCF) = 6.94 L/kg wet-wt., BCFBAF v3.01, Anderson, C (2019).
MB2-sulfonic acid: Bioconcentration factor (BCF) = 3.16 L/kg wet-wt., BCFBAF v3.01, Anderson, C (2019).
MB2-acetic acid: Bioconcentration factor (BCF) = 3.16 L/kg wet-wt., BCFBAF v3.01, Anderson, C (2019).
Hydroxy-MB2: Bioconcentration factor (BCF) = 10.5 L/kg wet-wt., BCFBAF v3.01, Anderson, C (2019).
Additional information
ZMB2 / MB2
WAIVER: In accordance with REACH Annex IX, Section 9.3.2, Column 2, bioaccumulation testing need not be conducted if:the substance has a low potential for bioaccumulation. LANXESS (2018 - see Section 13.2 of IUCLID) clearly shows that 2H-Benzimidazole-2-thione, 1,3-dihydro-4(or 5)-methyl-, zinc salt (2:1) (ZMB2), i.e. the registered substance, exhibits its salt characteristic in aqueous solution, i.e., dissolving in water to 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione (MB2) and zinc ions in a matter of seconds. Therefore, the measured log Pow value for ZMB2 is not considered relevant for bioaccumulation assessment as it will never exist in the aquatic environment. Instead, the data presented for MB2 (log Pow = 0.3 - 0.4) is most relevant for bioaccumulation potential. The low partitioning behaviour of MB2 is consistent with a conclusion of low bioaccumulation potential, and therefore bioaccumulation testing with the registered substance is not considered necessary.
Major transformation products identified in the OECD 309 water simulation study; desthio-MB2; MB2 -sulfonic acid; MB2 -acetic acid
in Silico profiling of four major transformation products observed in the OECD 309 simulation study (Gartner, C. 2019 - Section 5.2.2); desthio-MB2, MB2-sulfonic acid, MB2-acetic isomers and hydroxy-MB2 and structural analogues was conducted. A number of physical chemical and environmental fate properties based on (Q)SAR predictions and experimental data was compared and contrasted between the aforementioned target substances and their respective source substances. Endpoint data relating to the bioaccumulation potential of the substances was investigated thoroughly. For each substance, the log Kow, a key indicator endpoint for bioaccumulation potential, was predicted to be < 4.5. Further, BCF values for each of the major transformation products was predicted to be <2000 L/kg wet wt (actual: desthio MB2= 6.9 Lkg wet wt, MB2 -sulfonic acid, MB2 acetic acid = 3.2 L/kg wet wt and hydroxy-MB2 = 11 L/kg wet wt). It was concluded that desthio-MB2, MB2-sulfonic acid, MB2-acetic acid or hydroxy-MB2 did not meet the criteria for bioaccumulation (B).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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