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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 207-434-1 | CAS number: 471-01-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment. Restriction: No organ weight determination, no clinical biochemistry.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicology and carcinogenesis studies of isophorone in F344 rats and B6C3F1 mice.
- Author:
- Bucher JR, Huff J, Kluwe WM
- Year:
- 1 986
- Bibliographic source:
- Toxicology 39: 207-219
- Reference Type:
- review article or handbook
- Title:
- Toxicology and Carcinogenesis Studies of Isophorone in F344/N Rats and B6C3F1 Mice.
- Author:
- NTP (U.S. National Toxicology Program)
- Year:
- 1 986
- Bibliographic source:
- Techn Rep Ser No. 291, U.S. Department of Health and Human Services
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Repeated Dose Toxicity, U.S. NTP
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 3,5,5-trimethylcyclohex-2-enone
- EC Number:
- 201-126-0
- EC Name:
- 3,5,5-trimethylcyclohex-2-enone
- Cas Number:
- 78-59-1
- IUPAC Name:
- 3,5,5-trimethylcyclohex-2-en-1-one
- Details on test material:
- - Analytical purity: 97% , 0.3% water
- Origin: Leidy Chemical Corporation
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 8 weeks
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- - Total volume applied: 1 mL
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 13 weeks (91 days)
- Frequency of treatment:
- 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
62.5; 125; 250; 500; or 1000 mg/kg bw d
Basis:
actual ingested
- No. of animals per sex per dose:
- 10
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Post-exposure period: none
Examinations
- Observations and examinations performed and frequency:
- CLINICAL OBSERVATIONS AND FREQUENCY
Clinical signs: twice daily.
Mortality: twice daily.
Body weight: weekly.
Hematology: no.
Urinalysis: no.
Biochemistry: no. - Sacrifice and pathology:
- ORGANS EXAMINED AT NECROPSY (MACROSCOPIC AND MICROSCOPIC)
Organ weight: no.
Macroscopic: no details reported.
Microscopic: Skin, mammary gland, sciatic nerve, salivary gland, mandibular lymph node, thymus, heart, lungs, trachea, thyroid gland, parathyroids, esophagus, stomach, duodenum, jejunum, ileum, colon, rectum, mesenteric lymph node, pancreas, spleen, liver, kidneys, adrenal glands, urinary bladder, seminal vesicles, prostate/testes or ovaries/uterus, brain, pituitary gland, bone marrow, spinal cord, and nasal cavity. - Statistics:
- Survival, body weight, dose-related effects were statistically evaluated.
Results and discussion
Results of examinations
- Details on results:
- Mortality and time to death: 1 female (1000 mg/kg, week 5).
Clinical signs: Rats that received 1000 mg/kg were sluggish and lethargic after dosing.
Body weight: 1000 mg/kg bw, males: slightly reduced body weight gain. (No information given on significance)
Gross pathology: No compound-related pathologic effects were observed.
Histopathology: No compound-related pathologic effects were observed.
Other: Toxic changes in the kidneys were not found, even by recuts and special stains.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 500 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: reduced body weight gain (males) mortality (females)
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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