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Diss Factsheets
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EC number: 203-862-8 | CAS number: 111-36-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
acute oral toxicity: LD50 = 360 mg/kg bw (rat, male)
acute dermal toxicity: ALD = 700 mg/kg bw (ALD = The lowest dose at which one or more animals died)
acute inhalation toxicity: LC50 = 59 mg/m³ (rat, male+female)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 360 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 59 mg/m³
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- discriminating dose
- Value:
- 700 mg/kg bw
Additional information
The oral LD50 was determined to be 360 mg/kg bw for rats. Toxic symptoms included apathy, stiff gait, and labored breathings. Acute inhalation toxicity studies revealed that n-butyl isocyanate is highly toxic when inhaled. The LC50 (rat, 4h) value reported in a study according to OECD TG 403 with vapor inhalation is 59 mg/m³. Assessment of the acute inhalation toxicity data indicates that the primary toxic effects in response to exposure to evaporated n-butyl isocyanate are focused on the portal of entry, the respiratory tract. Thus death is due to severe respiratory tract lesions. Special investigations with male rats revealed overt inflammatory responses in the lung, which also could be confirmed histopathologically. The prominent microscopic changes were increased number of macrophages, perivascular round-cell infiltration, focal fibroproliferative reactions, emphysema, thickening septa, and abscessive pneumonia. Inflammation of the airways became prominent after exposure of a lethal concentration (50 mg/m³, 1x4h) and was marginally pronounced at a sublethal concentration (25 mg/m³, 1x4h)). No significant changes other than transient clinical signs were observed at 8 mg/m³. Ca. 3 mg/m³ were tolerated without any symptoms. For acute dermal toxicity only not assignable/invalid studies are available.
Justification for classification or non-classification
For the acute oral toxicity Xn, R22 is justified as a result of the LD50 = 360 mg/kg bw
For the acute inhalation toxicity T+, R26 is justified as a result of the LC50 = 59 mg/m³ air
In addition, several studies reported respiration irritational effects. Therefore R 37 is applicable
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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