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Diss Factsheets
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EC number: 944-461-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 Sep - 22 Oct 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: SEPA, The Guidelines for the Testing of Chemicals, 2004, 209 Activated Sludge, Respiration Inhibition Test.
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
The test substance was directly weighted and added into the test vessels. - Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- - Source: a fresh sample of activated sludge for the range-finding was collected from the aeration stage of Longhua Wastewater Treatment Plant in
Shanghai which treated predominantly domestic sewage on 2013-09-11 and for the definitive test on 2013-10-21.
- Preparation of inoculum for exposure: the sludge was washed with an isotonic solution containing 0.85% NaCI (w/v). After centrifuging the supernatant was decanted. This procedure was repeated 3 times (4000rpm, 4 °C, centrifuge 20 minutes). A small amount (0 .1 - 0.5 g) of the washed sludge was weighed and dried at 105 °C for 1h to calculate the dry weight. The dry weight of sludge used in range-finding test count up to 6.64% of the gross weight and in the definitive test count up to 4.94%, respectively.
- Initial biomass concentration: 1.5 g/L - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Post exposure observation period:
- none
- Nominal and measured concentrations:
- Test concentrations: 92.3, 171, 309, 556, 1000 mg/L (nominal)
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 1000 mL glass vessels
- Aeration: yes, ca. 1 L air/min
EFFECT PARAMETERS MEASURED: dissolved oxygen at the begining and at the end of the experiment
TEST CONCENTRATIONS
- Range finding study
- Test concentrations: 10, 100, 1000 mg/L (nominal)
- Results used to determine the conditions for the definitive study: IC50 > 1000 mg/L (nominal) - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol
- Duration:
- 3 h
- Dose descriptor:
- IC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: respiration inhibition
- Results with reference substance (positive control):
- IC50 = 13.53 mg/L
Reference
Description of key information
IC50 (3 h) > 1000 mg/L (OECD 209)
Key value for chemical safety assessment
Additional information
One study investigating the toxicity of Reaction mass of 1,1'-(isopropylidene)bis[3,5-dibromo-4-(2,3-dibromo-2-methylpropoxy)benzene] and 1,3-dibromo-2-(2,3-dibromo-2-methylpropoxy)-5-{2-[3,5-dibromo-4-(2,3,3-tribromo-2-methylpropoxy)phenyl]propan-2-yl}benzene to microorganisms is available (Jing, 2014). The study was performed according to the OECD guideline 209 and GLP. A range finding test was conducted. Synthetic sewage was tested for 3 h on 5 different concentrations of 92.3, 171, 309, 556 and 1000 mg/L at 20.9 °C. 3,5-dichlorophenol was used as a reference substance. The rate of respiration was recorded. Results revealed an IC50 (3 h) of > 1000 mg/L.
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