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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 264-780-6 | CAS number: 64338-16-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 6.61 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 10
- Dose descriptor starting point:
- NOAEL
- Value:
- 75 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 66.12 mg/m³
- Explanation for the modification of the dose descriptor starting point:
The original study is reliable without restrictions.
The route to route extrapolation was performed by applying the equation as cited in Guidance on information requirements and chemical safety assessment, Chapter R.8 (by ECHA) with all recommended assessment factors.
- AF for dose response relationship:
- 1
- Justification:
- NOAEL is the starting point for DNEL derivation. According to Guidance on information Chapter R.8, p. 30, the assessment factor is 1.
- AF for differences in duration of exposure:
- 2
- Justification:
- according to Guidance on information Chapter R.8, Table 8-5, p. 29
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- interspecies difference is included in the calculation by correcting the respiratory volumes of rat and man (for details refer to "explanation for hazard conclusion")
- AF for other interspecies differences:
- 1
- Justification:
- interspecies difference is included in the calculation by correcting the respiratory volumes of rat and man (for details refer to "explanation for hazard conclusion")
- AF for intraspecies differences:
- 5
- Justification:
- according to Guidance on information Chapter R.8, Table 8-6, p. 32
- AF for the quality of the whole database:
- 1
- Justification:
- Original study is reliable without restriction
- AF for remaining uncertainties:
- 1
- Justification:
- No adverse effects were observed in this study up to 75 mg/kg bw/day (females), the highest dose tested. Therefore the NOAEL of this study was >/= 75 mg/kg bw/day and no further uncertainties assumed
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 5
- Dose descriptor starting point:
- NOAEC
- Value:
- 559.5 mg/m³
- Modified dose descriptor starting point:
- other: LC50
- Value:
- 1 670 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Since original study was via inhalation route no route-to-route extrapolation is mandatory
- AF for dose response relationship:
- 1
- Justification:
- LC50 is the starting point for DNEL derivation. According to Guidance on information Chapter R.8, p. 30, the assessment factor is 1.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- interspecies difference is included in the calculation by correcting the respiratory volumes of rat and man (for details refer to "explanation for hazard conclusion")
- AF for other interspecies differences:
- 1
- Justification:
- interspecies difference is included in the calculation by correcting the respiratory volumes of rat and man (for details refer to "explanation for hazard conclusion")
- AF for intraspecies differences:
- 5
- Justification:
- according to Guidance on information Chapter R.8, Table 8-6, p. 32
- AF for the quality of the whole database:
- 1
- Justification:
- Original study is reliable
- AF for remaining uncertainties:
- 1
- Justification:
- No further uncertainties assumed.
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.88 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 40
- Dose descriptor starting point:
- NOAEL
- Value:
- 75 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Since a dermal absoprtion of 100% was assumed the orally derived dose descriptor starting point does not need to be modified.
- AF for dose response relationship:
- 1
- Justification:
- NOAEL is the starting point for DNEL derivation. According to Guidance on information Chapter R.8, p. 30, the assessment factor is 1.
- AF for differences in duration of exposure:
- 2
- Justification:
- according to Guidance on information Chapter R.8, Table 8-5, p. 29
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- according to Guidance on information Chapter R.8, Table 8-3, p. 24
- AF for other interspecies differences:
- 1
- Justification:
- no additional AF for interspecies differences assumed
- AF for intraspecies differences:
- 5
- Justification:
- according to Guidance on information Chapter R.8, Table 8-6, p. 32
- AF for the quality of the whole database:
- 1
- Justification:
- Original study is reliable without restriction
- AF for remaining uncertainties:
- 1
- Justification:
- No adverse effects were observed in this study up to 75 mg/kg bw/day (females), the highest dose tested. Therefore the NOAEL of this study was >/= 75 mg/kg bw/day and no further uncertainties assumed
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 20
- Dose descriptor starting point:
- other: LD50
- Value:
- 2 800 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 2 800 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Since a dermal absoprtion of 100% was assumed the orally derived dose descriptor starting point does not need to be modified.
- AF for dose response relationship:
- 1
- Justification:
- LD50 is the starting point for DNEL derivation. According to Guidance on information Chapter R.8, p. 30, the assessment factor is 1.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- according to Guidance on information Chapter R.8, Table 8-3, p. 24
- AF for other interspecies differences:
- 1
- Justification:
- no additional AF for interspecies differences assumed
- AF for intraspecies differences:
- 5
- Justification:
- according to Guidance on information Chapter R.8, Table 8-6, p. 32
- AF for the quality of the whole database:
- 1
- Justification:
- Original study is reliable
- AF for remaining uncertainties:
- 1
- Justification:
- No further uncertainties assumed.
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- skin irritation/corrosion
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
please refer to "explanation for hazard conclusion" of each hazard point
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.63 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 20
- Dose descriptor starting point:
- NOAEL
- Value:
- 75 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 32.61 mg/m³
- Explanation for the modification of the dose descriptor starting point:
The route to route extrapolation was performed by applying the equation as cited in Guidance on information requirements and chemical safety assessment, Chapter R.8 (by ECHA) with all recommended assessment factors.
- AF for dose response relationship:
- 1
- Justification:
- NOAEL is the starting point for DNEL derivation. According to Guidance on information Chapter R.8, p. 30, the assessment factor is 1.
- AF for differences in duration of exposure:
- 2
- Justification:
- according to Guidance on information Chapter R.8, Table 8-5, p. 29
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- interspecies difference is included in the calculation by correcting the respiratory volumes of rat and man (for details refer to "explanation for hazard conclusion")
- AF for other interspecies differences:
- 1
- Justification:
- interspecies difference is included in the calculation by correcting the respiratory volumes of rat and man (for details refer to "explanation for hazard conclusion")
- AF for intraspecies differences:
- 10
- Justification:
- according to Guidance on information Chapter R.8, Table 8-6, p. 32
- AF for the quality of the whole database:
- 1
- Justification:
- Original study is reliable without restriction
- AF for remaining uncertainties:
- 1
- Justification:
- No adverse effects were observed in this study up to 75 mg/kg bw/day (females), the highest dose tested. Therefore the NOAEL of this study was >/= 75 mg/kg bw/day and no further uncertainties assumed
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
.
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.94 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 80
- Dose descriptor starting point:
- NOAEL
- Value:
- 75 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Since a dermal absoprtion of 100% was assumed the orally derived dose descriptor starting point does not need to be modified.
- AF for dose response relationship:
- 1
- Justification:
- NOAEL is the starting point for DNEL derivation. According to Guidance on information Chapter R.8, p. 30, the assessment factor is 1.
- AF for differences in duration of exposure:
- 2
- Justification:
- according to Guidance on information Chapter R.8, Table 8-5, p. 29
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- according to Guidance on information Chapter R.8, Table 8-3, p. 24
- AF for other interspecies differences:
- 1
- Justification:
- no additional AF for interspecies differences assumed
- AF for intraspecies differences:
- 10
- Justification:
- according to Guidance on information Chapter R.8, Table 8-6, p. 32
- AF for the quality of the whole database:
- 1
- Justification:
- Original study is reliable without restriction
- AF for remaining uncertainties:
- 1
- Justification:
- No adverse effects were observed in this study up to 75 mg/kg bw/day (females), the highest dose tested. Therefore the NOAEL of this study was >/= 75 mg/kg bw/day and no further uncertainties assumed
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- skin irritation/corrosion
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.94 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 80
- Dose descriptor starting point:
- NOAEL
- Value:
- 75 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
No modification of dose descriptor starting point needed since original study used oral route.
- AF for dose response relationship:
- 1
- Justification:
- NOAEL is the starting point for DNEL derivation. According to Guidance on information Chapter R.8, p. 30, the assessment factor is 1.
- AF for differences in duration of exposure:
- 2
- Justification:
- according to Guidance on information Chapter R.8, Table 8-5, p. 29
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- according to Guidance on information Chapter R.8, Table 8-3, p. 24
- AF for other interspecies differences:
- 1
- Justification:
- no additional AF for interspecies differences assumed
- AF for intraspecies differences:
- 10
- Justification:
- according to Guidance on information Chapter R.8, Table 8-6, p. 32
- AF for the quality of the whole database:
- 1
- Justification:
- Original study is reliable without restriction
- AF for remaining uncertainties:
- 1
- Justification:
- No adverse effects were observed in this study up to 75 mg/kg bw/day (females), the highest dose tested. Therefore the NOAEL of this study was >/= 75 mg/kg bw/day and no further uncertainties assumed
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - General Population
please refer to "explanation for hazard conclusion" of each hazard point
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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