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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 204-467-3 | CAS number: 121-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Acute oral toxicity (similar to OECD TG 401): 2300 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November - December, 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Remarks:
- Pre-OECD test guideline study and pre-GLP
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: Sherman-Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Three males and two females of the Sherman-Wistar strain.
- Fasting period before study: 24 hours
- Diet: Free access to food
- Water: Free access to water
- Acclimation period: one week
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 3.16 mL/kg bw
Doses were administered directly into the stomach by means of a stomach tube. The substance was applied as a 4% solution, the toxicity was converted to 100% substance.
- Doses:
- 1.26, 1.6, 2.0, 2.5 and 3.16 mL/kg bw
- No. of animals per sex per dose:
- Three males and two females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Daily
- Necropsy of survivors performed: No data - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Remarks:
- the LD50 is converted to the pure substance
- Effect level:
- 2 300 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Confidence limits 2000 - 2600 mg/kg.
- Mortality:
- 1/5 animals died at 2.0 mL/kg bw, 4/5 animals died at 2.5 mL/kg bw and all 5 animals died at 3.16 mL/kg bw.
- Clinical signs:
- No data.
- Body weight:
- No data.
- Gross pathology:
- No data.
- Interpretation of results:
- other: Not acute harmful.
- Remarks:
- According to EU CLP Regulation (EC) No. 1272/2008 and its amendments
- Conclusions:
- The LD50 is 2300 mg/kg bw and based on this result, the substance is not acute harmful. According to GHS the substance needs to be classified for acute oral toxicity category 5 and labelled with H303: May be harmful if swallowed.
- Executive summary:
In an acute oral toxicity study performed equivalent to OECD 401 guideline, five groups of rats (three males and two females) were orally exposed to a 4% solution of the substance. When converted to 100% substance the doses were 2 – 3.16 ml/kg bw. The rats were observed for signs of toxicity for a period of 14 days. 1/5 animals died at 2.0 mL/kg bw, 4/5 animals died at 2.5 mL/kg bw and all 5 animals died at 3.16 mL/kg bw, resulting in an LD50 of 2.3 mL/kg bw. This will value will be conservatively converted into 2300 mg/kg bw (In view of the relative density of the substance: 1.125, the LD50 is actually 2588 mg/kg bw). Based on this result, the substance is not acute harmful.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The acute oral toxicity result is of sufficient quality and adequate for this dossier.
Additional information
Acute oral toxicity:
In an acute oral toxicity study performed equivalent to OECD 401 guideline, five groups of rats (three males and two females) were orally exposed to a 4% solution of the substance. When converted to 100% substance the doses were 2 – 3.16 ml/kg bw. The rats were observed for signs of toxicity for a period of 14 days. 1/5 animals died at 2.0 mL/kg bw, 4/5 animals died at 2.5 mL/kg bw and all 5 animals died at 3.16 mL/kg bw, resulting in an LD50 of 2.3 mL/kg bw. This will value will be conservatively converted into 2300 mg/kg bw (In view of the relative density of the substance: 1.125, the LD50 is actually 2588 mg/kg bw). Based on this result, the substance is not acute harmful.
Justification for classification or non-classification
The substance does not have to be classified for acute toxicity by the oral route according to EU CLP (EC,1272/2008 and its amendments).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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