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Diss Factsheets
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EC number: 954-598-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Short-term aquatic toxicity to invertebrates
EC50 (48h) = 6.8 mg/l
Toxicity to aquatic plants other than algae
ErC50 = 10.6 mg/l (effects on dry weight)
NOErC < 3.36 mg/l (effects on dry weight)
Additional information
The following tests are available on the similar substance 1:
Short-term aquatic toxicity to invertebrates
The test substance was tested in acute immobilisation test on Daphnia magna, according to method C.2 – Daphnia sp. Acute Immobilisation Test, Council Regulation (EC) No. 440/2008.
The preliminary test was performed in a range of the test substance nominal concentrations 1 – 100 mg·L-1.Based on toxicity of the test substance found in the preliminary test, the definitive test was performed in appropriate concentration range. The definitive test was performed static, in a range of the test substance nominal concentrations 1 – 50 mg·L-1.
The study was performed without analytical determination of the test substance concentrations. Only the concentrations of Total organic carbon (TOC) in the lowest and in the highest tested concentration were analysed in the preliminary and definitive test.Samples for determination of the TOC concentrations were taken at the beginning and at the endof the test.The nominal concentrations were used for all evaluation and results.
The EC50 calculated in this test in a 48 hours observation window is 6.8 mg/l.
Toxicity to aquatic plants other than algae
The inhibitory effects of the test substance to the duckweed Lemna minor were investigated over a period of 7 days, based on the frond number and biomass (dry weight), following the guideline OECD 221.
The test solutions were prepared by respective dilutions of a stock solutionin STEINBERG Medium.
The test was performed at 100, 50.0, 25.0, 12.5 and 6.25 mg/l nominal concentration of the test substance, corresponding to 61.9, 31.0, 15.5, 7.74 and 3.87 mg/l of the active ingredient.
Three parallel test vessels were used for each test concentration of the test item and six vessels for the blank controls.
The test concentrations during the 7-day test period were determined by photometry at the beginning of the test, as well as after 3, 5 and 7 days of exposure. These analyses confirmed the right dosage of the test item, and showed that the concentrations of the test item slightly decreased over the whole 7-day test period. Therefore, the effective concentrations (ErCxand EyCx) were assessed based on the geometric mean (GM) of the measured concentrations of the active ingredient.
The two endpoints frond number and biomass (dry weight) were investigated at days 3, 5 and 7, and each of them were assessed as growth rate and yield.
The ErC50 value, based on frond number and dry weight, was respectively 17.5 and 10.6 mg/l. The NOErC was 3.36 mg/l based on frond number and < 3.36 mg/l based on dry weight.
Justification for classification or non-classification
According to the CLP Regulation (EC n. 1272/2008), Part 4: Environmental Hazards, the substances can be classified for hazardous to the aquatic environment (fish toxicity) when the following criteria are met:
A )Acute (short-term) aquatic hazard
Category Acute 1:
96 hr LC 50 (for fish) ≤ 1 mg/l and/or
48 hr EC 50 (for crustacea) ≤ 1 mg/l and/or
72 or 96 hr ErC 50 (for algae or other aquatic plants) ≤ 1 mg/l
B) Long-term aquatic hazard
(iii) Substances for which adequate chronic toxicity data are not available
Category Chronic 1:
96 hr LC 50 (for fish) ≤ 1 mg/l and/or
48 hr EC 50 (for crustacea) ≤ 1 mg/l and/or
72 or 96 hr ErC 50 (for algae or other aquatic plants) ≤ 1 mg/l
and the substance is not rapidly degradable and/or the experimentally determined BCF ≥ 500 (or, if absent, the log K ow ≥ 4).
Category Chronic 2:
96 hr LC 50 (for fish) > 1 to ≤10 mg/l and/or
48 hr EC 50 (for crustacea) > 1 to ≤10 mg/l and/or
72 or 96 hr ErC 50 (for algae or other aquatic plants) > 1 to ≤10 mg/l (Note 2)
and the substance is not rapidly degradable and/or the experimentally determined BCF ≥ 500 (or, if absent, the log K ow ≥ 4).
Category Chronic 3:
96 hr LC 50 (for fish) > 10 to ≤ 100 mg/l and/or
48 hr EC 50 (for crustacea) > 10 to ≤ 100 mg/l and/or
72 or 96 hr ErC 50 (for algae or other aquatic plants) > 10 to ≤ 100 mg/l
and the substance is not rapidly degradable and/or the experimentally determined BCF ≥ 500 (or, if absent, the log K ow ≥ 4).
Category Chronic 4
Cases when data do not allow classification under the above criteria but there are nevertheless some grounds for concern. This includes, for example, poorly soluble substances for which no acute toxicity is recorded at levels up to the water solubility (note 4), and which are not rapidly degradable in accordance with section 4.1.2.9.5 and have an experimentally determined BCF ≥ 500 (or, if absent, a log K ow ≥ 4), indicating a potential to bioaccumulate, which will be classified in this category unless other scientific evidence exists showing classification to be unnecessary. Such evidence includes chronic toxicity NOECs > water solubility or > 1 mg/l, or other evidence of rapid degradation in the environment than the ones provided by any of the methods listed in section 4.1.2.9.5.
The EC50 value calculated for the test substance on the "short-term aquatic toxicity to invertebrates" (Daphnia) was established to be 6.8 mg/l, therefore the substance is classified as Category Chronic 2 (48 hr EC 50 (for crustacea) > 1 to ≤10 mg/l) according to the CLP Regulation (EC n. 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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