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EC number: 214-688-7 | CAS number: 1185-81-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23rd to 25th August 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Dibutylbis(dodecylthio)stannane
- EC Number:
- 214-688-7
- EC Name:
- Dibutylbis(dodecylthio)stannane
- Cas Number:
- 1185-81-5
- Molecular formula:
- C32H68S2Sn
- IUPAC Name:
- dibutylbis(dodecylsulfanyl)stannane
- Details on test material:
- Identity Provided by Test Article: Dabco T120 Catalyst
Batch No.: 817231
Date Received: 08/13/10
Storage: Room temperature and humidity
Description: Clear liquid
Sample Preparation: Used as received
Constituent 1
In vitro test system
- Test system:
- artificial membrane barrier model
- Source species:
- other: artificial membrane barrier model
- Cell type:
- other: artificial membrane barrier model
- Cell source:
- other: artificial membrane barrier model
- Source strain:
- other: not applicable, artificial membrane barrier model
- Vehicle:
- unchanged (no vehicle)
- Amount/concentration applied:
- 150 µl
- Duration of treatment / exposure:
- The Corrositex® test predicts the in vivo corrosive potential of a chemical compound or mixture by using as an endpoint the amount of time it takes for a chemical to permeate through or destroy a synthetic biobarrier.
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: Mean breakthrough time (minutes)
- Run / experiment:
- mean
- Value:
- > 120
- Remarks on result:
- other: The results obtained from the evaluation of four replicate tests demonstrated that a mean time of >1 20.0 minutes was required to destroy the synthetic biobarriers.
Any other information on results incl. tables
The test article was analyzed using the Corrositex® test method to determine its dermal corrosivity potential and U.N. Packing Group classification. The 1.0 N sodium hydroxide positive control had a
breakthrough time of 18.0 minutes, which fell within the range allowed (13.4 and <22.2 minutes). The results of this study indicated that the test article was compatible with the Corrositex® system and
was determined to be a Category 2 material. The results obtained from the evaluation of four replicate tests demonstrated that a mean time of >120.0 minutes was required to destroy the synthetic biobarriers. These findings lead to the classification of this test article as a Non-Corrosive material.
Table 2. Categorization results
Concentration tested 100%
Color in Tube A None
Color in Tube B Green*
Category 2
* = confirm reagent added
Table 3. Classification results
Replicate Breakthrough time (minutes)
#1 >120
#2 >120
#3 >120
#4 >120
Mean >120
Packing group Non-corrosive
Corrosivity Non-corrosive
Applicant's summary and conclusion
- Interpretation of results:
- other: Non-Corrosive Criteria used for interpretation of results: other: U.N. Packing Group classification
- Conclusions:
- The results obtained from the evaluation of four replicate tests demonstrated that a mean time of >120.0 minutes was required to destroy the synthetic biobarriers.
- Executive summary:
The test article was qualified, categorized, and found to be compatible with the Corrositex® test system. 500 μl of the test article were then added to the Corrositex® test vials containing biobarriers and the
time required for the test material to destroy the biobarrier was recorded. The positive control (500 μl 1.0 N sodium hydroxide) was also tested. The mean breakthrough time, which predicts the in vivo corrosive potential of the test material, was used to designate the United Nations (U.N.) Packing Group classification.
The results obtained from the evaluation of four replicate tests demonstrated that a mean time of >120.0 minutes was required to destroy the synthetic biobarriers. These findings lead to the classification of this test article as a Non-Corrosive material.
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