Registration Dossier
Registration Dossier
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EC number: 281-192-5 | CAS number: 83897-84-1
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
Description of key information
Calcium magnesium carbonate oxide Akdolit CMG:
Total Dustiness (airborne fraction): 1.44 mg/g (experimental result, DMT Report).
MMAD (bimodal distribution) of airborne fraction: MMAD1 = 17.77 µm (39.5 %) , MMAD2 = 44.39 µm (60.5 %) (distribution fitted to cascade impactor data, percentage in parentheses indicates weighting factor).
GSD: GSD1 = 1.10 µm, GSD 2 = 4.48 µm
Fractional deposition in human respiratory tract (MPPD model, based on calculated MMAD):
Head (ET): 56.8 %; Tracheobronchial (TB): 0.2 %; Pulmonary (PU): 0.4 %
Calcium magnesium carbonate oxide 0-2mm:
Total Dustiness (airborne fraction): 201.56 mg/g (experimental results, DMT Report).
MMAD of airborne fraction: MMAD = 30.31 µm (distribution fitted to cascade impactor data).
GSD of MMAD: GSD = 1.79 µm
Fractional deposition in human respiratory tract (MPPD model, based on calculated MMAD):
Head (ET): 45.3 %; Tracheobronchial (TB): 0.1 %; Pulmonary (PU): 0.0 %
Additional information
For the evaluation of this endpoint, two grades of calcium magnesium carbonate oxide (calcium magnesium carbonate oxide Akdolit CMG and calcium magnesium carbonate oxide 0-2 mm) were investigated according to national standard (DIN 55992 -1:2006, modified Heubach method). The respective results are used as key information, supported by data from a guideline compliant study (OECD 110).
The key studies were selected based on the fact that these studies consider the airborne fraction of calcium magnesium carbonate oxide, which is exposure-related and relevant to workplace conditions. The other study, which is only used as supportive information, tested not the airborne fraction of calcium oxide, but the total of the substance fed in a cascade impactor. This is not exposure-related and not relevant for workplace conditions.
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