Registration Dossier
Registration Dossier
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EC number: 201-553-2 | CAS number: 84-69-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Article published in established peer-reviewed journal.
Data source
Reference
- Reference Type:
- publication
- Title:
- A Toxicological Investigation of Some Acute, Short-Term, and Chronic Effects of Administering Di-2-Ethylhexyl Phthalate (DEHP) and Other Phthalate Esters
- Author:
- Lawrence, W.H., Malik, M., Turner, J.E., Singh, A.R., and Autian, J.
- Year:
- 1 975
- Bibliographic source:
- Journal of Environmental Research, 9, 1-11.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- di-isobutyl phthalate
- IUPAC Name:
- di-isobutyl phthalate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Observation period : 7 days post-doe (end-point - mortality)
- Doses:
- Not specified
- No. of animals per sex per dose:
- Groups of 10 males
- Statistics:
- The LD50 95% confidence interval and slope were calculated from the 7-day mortality data by Cornfield and Mantels' (1950) modification of Karber's method.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 3.99 other: g/kg bw
- Based on:
- not specified
- 95% CL:
- >= 3.91 - <= 4.08
- Remarks on result:
- other: IP LD50 also reported as 3.84 mL/kg bw
Any other information on results incl. tables
Results: IP LD50 3.99 g/kg (95% confidence interval 3.91 – 4.08); IP LD50 3.84 mL/kg
Applicant's summary and conclusion
- Conclusions:
- Results:
IP LD50 3.99 g/kg (95% confidence interval 3.91 – 4.08); IP LD50 3.84 mL/kg
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