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EC number: 204-527-9 | CAS number: 122-19-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- From June 22, 1987 to July 28, 1987.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Justification for type of information:
- Refer to the section 13 of IUCLID dataset for details on the read across justification. The algae study with the read across substance is considered sufficient to fulfil the information requirements as further explained in the provided endpoint summary.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- test media renewal after 48h. Analysis of the test substance was not performed.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- yes
- Remarks:
- test media renewal after 48h. Analysis of the test substance was not performed.
- Principles of method if other than guideline:
- Explanations and other deviations:
No chemical analyses but data from other tests demonstrate the stability and availability of the test substance under test conditions.
The second acclimatisation time is shorter than advised by the guideline but considering the low mortality during the second period. This is considered to have no impact on the final outcome of the test. - GLP compliance:
- yes
- Analytical monitoring:
- no
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Species/strain: Salmo gairdneri
Source: Forellenhof Fredesloh, Dr. O. Mueller, 3413 Moringen 1
Wild caught: no
Age/size: 5 ± 1 cm
Food: trout food Pelletgr. S1 (Rheinkrone Kraftfutter)
Pretreatment: during the first time of the adaptation phase (12d) the mortality came to 7% of the fish population. Therefore, the adaptation phase was extended for 5d. During this time the mortality only came to 0.5% of the fish population. 24h before the test started feeding of the fish was stopped.
Feeding of animals during test: no - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- ca. 14°C
- pH:
- ca. 8
- Dissolved oxygen:
- ca. 10 mg/L
- Nominal and measured concentrations:
- Nominal concentrations: 0, 0.5, 0.7, 1.0, 1.4, 2.0, 3.5 and 10.0 mg/L.
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 0.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.85 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 1.75 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Details on results:
- During the first time of the adaptation phase (12d) the mortality came to 7% of the fish population. Therefore the adaptation phase was extended for 5d. During this time the mortality only came to 0.5% of the fish population. The oxygen content of the water was above 60% during the test and according to analyses in other tests (e.g. algae test), the test substance concentration was above 80% of the initial concentration during the test. Therefore all validity criteria are fulfilled. The concentration-response relationship appears to be typical for this type of substance. The study can be considered as valid.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the results of the read across study, the 96h LC0, LC50 and LC100 values (Oncorhynchus mykiss) for the test substance can be considered to be 1.4 mg/L (i.e., equivalent to 0.7 mg a.i./L), 1.7 mg/L (i.e., equivalent to 0.85 mg a.i./L) and 3.5 mg/L (i.e., equivalent to 1.75 mg a.i./L) (nominal).
- Executive summary:
A study was conducted to determine the short-term toxicity to fish of the read across substance (active: 50%), C12-16 ADBAC, according to OECD Guideline 203 and EU Method C.1, in compliance with GLP. The experiment was conducted in Rainbow trout (Onchorhynchus mykiss) under static conditions. Fish (5 animals in duplicate) were exposed for 96 h to concentrations of 0, 0.5, 0.7, 1.0, 1.4, 2.0, 3.5 and 10.0 mg/L. No chemical analysis of test concentrations was performed. Abnormal findings during the exposure period were recorded in the swimming behaviour, visible physiological functions and outward appearance of the fish. Under the study conditions, the 96 h LC0, LC50 and LC100 values were determined to be 1.4 mg/L (i.e., equivalent to 0.7 mg a.i./L), 1.7 mg/L (i.e., equivalent to 0.85 mg a.i./L) and 3.5 mg/L (i.e., equivalent to 1.75 mg a.i./L) nominal (Dommrose, 1987). Based on the results of the read across study, similar the 96 h LC50 value can be considered for the test substance, C18 ADBAC, for short-term toxicity tofish.
Reference
Description of key information
Based on the results of the read across study, the 96h LC0, LC50 and LC100 values of the test substance, C18 ADBAC, for toxicity to fish is considered to be 1.4 mg/L (i.e., equivalent to 0.7 mg a.i./L), 1.7 mg/L (i.e., equivalent to 0.85 mg a.i./L) and 3.5 mg/L (i.e., equivalent to 1.75 mg a.i./L) respectively (nominal).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.85 mg/L
Additional information
A study was conducted to determine the short-term toxicity to fish of the read across substance (active: 50%) C12 -16 ADBAC, according to OECD Guideline 203 and EU Method C.1, in compliance with GLP. The experiment was conducted in Rainbow trout (Onchorhynchus mykiss) under static conditions. Fish (5 animals in duplicate) were exposed for 96 h to concentrations of 0, 0.5, 0.7, 1.0, 1.4, 2.0, 3.5 and 10.0 mg/L. No chemical analysis of test concentrations was performed. Abnormal findings during the exposure period were recorded in the swimming behaviour, visible physiological functions and outward appearance of the fish. Under the study conditions, the 96h LC0, LC50 and LC100 values of the read across substance in Oncorhynchus mykiss were determined to be 1.4 mg/L (i.e., equivalent to 0.7 mg a.i./L), 1.7 mg/L (i.e., equivalent to 0.85 mg a.i./L) and 3.5 mg/L (i.e., equivalent to 1.75 mg a.i./L) respectively (nominal) (Dommrose, 1987). Based on the results of the read across study, similar the 96 h LC50 value can be considered for the test substance, C18 ADBAC, for short-term toxicity to fish.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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