Registration Dossier
Registration Dossier
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EC number: 269-323-4 | CAS number: 68223-93-8
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The conservative value of LC 50 = 100 mg/L were chosen.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
Weight of evidence approach: data on short-term toxicity to fish were provided by using a validated QSAR model and by using data from an acute fish toxicity study of thioglycolic acid (TGA). TGA were chosen as a read-across substance because it is readily biodegradable and one of the degradation products were dithiodiglycolic acid (DTDGA). Therefore, in the acute fish toxicity study of Böttcher DADTDG were tested together with TGA. Studies with thioglycolic acid and its salts can be used as a surrogate for DADTDG.
The neutral (DTDGA 96h-LC50 >100 g/L) and the acidic (DADTDG 96h-LC50 > 50 g/L) form of the substance were used in the EPI Suite program. The 96h-LC50 from the QSAR program provides values by the factor of 500 and 1000 higher than the measured LC50 value for TGA (96h-LC50 > 100 mg/L).
Since the two other taxonomic groups (invertebrates, algae) showed the same range of toxicity (E/LC >100 mg/L), it can be concluded that DADTDG, the degradation product of TGA, does not effect fish at a concentration of 100 mg/L.
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