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Diss Factsheets
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EC number: 241-523-6 | CAS number: 17526-94-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
For the assessment of the short-term toxicity of TDI-urone to aquatic freshwater organisms one reliable GLP study each conducted according to standard guidelines is available for fish, daphnia, algae, and activated sludge, respectively.
In a 96-h acute toxicity limit test with carp (OECD 203) seven carp per test group were exposed to a control (0 mg/l) and a TDI-urone concentration of 100 mg/l (actual concentration). TDI-urone did not induce visible or lethal effects in carp at 100 mg/l (NOEC).
In a limit test with Daphnia magna (OECD 202) twenty daphnia per test group (4 replicates, 5 daphnia per replicate) were exposed to both a control (0 mg/l) and a TDI-urone concentration of 100 mg/l. The total test period was 48 hours. The 48h-EC50 exceeded 100 mg/l (actual concentration). In fact, TDI-urone did not induce acute immobilisation of Daphnia magna at 100 mg/l after 48 hours of exposure (NOEC).
The freshwater algae Pseudokirchneriella subcapitata was tested for growth inhibition by TDI-Urone according to the OECD guideline 201 limit test that was combined with a range-finding test. Six replicates of exponentially growing algal cultures were exposed to a control (0 mg/l) and a TDI-urone concentration of 100 mg/l in the limit test. Three replicates per test group were exposed to 0.10, 1.0 and 10 mg/l in the combined range-finding test. No significant reduction of growth rate or inhibition of yield was recorded after a test duration of 72 h in any of the concentrations of TDI-urone tested. The NOEC for growth rate reduction and yield inhibition is 100 mg/l.
In addition TDI-urone did not influence the respiration rate of activated sludge at a concentration up to 1,000 mg/l after a contact time of 3 hours in a test according to OECD guideline 209. Therefore, it can be concluded that TDI-urone is not toxic to wastewater (activated sludge) bacteria at a concentration of 1000 mg/l (NOEC).
For details on the information referenced above please refer to the individual sections.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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