Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 273-282-8 | CAS number: 68955-56-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
C36 -alkylenediamines are very poorly soluble in water and also have a strong tendency to adsorb to negatively charged surfaces such as suspended matter and test vessels or organic material (including dissolved organic matter such as humic acids). Many cationic substances in general but long chain amines in particular rank among the most difficult substances to test in environmental toxicology. Standard guideline studies are inappropriate to test substances with such properties and the current REACH Guidance Documents do not provide sufficient guidance concerning bioavailability and exposure assessment for cationic surface-active substances like the C36 -alkylenediamines as these were written with normal hydrophobic chemicals in mind, failing to take into account the lack of bioavailability that occurs in the environment with these substances. C36 -alkylenediamines is considered to be inherently biodegradable and considered to be stable under ecotox testing conditions. The aquatic ecotoxicity tests with C36 -alkylenediamines were, due to the extreme low water solubility, performed using the Water Accommodated Fraction (WAF) approach and effects if observed are presented based on loading and observed dissolved concentration.
An overview of the most relevant results is provided in the table.
Method |
Results |
Results, converted to active ingredient |
Remarks |
Reference |
|
||||
Acute fish 96h OECD 203 |
No effects observed LL0 = 100 mg/L LC0 = 275 µg/L |
No effects observed
LL0 = 99.9 mg/L LC0 = 275 µg/L |
Reliability 1
Loading Geomean measured |
Akzonobel, 2012 |
|
|
|
||
Acute Daphnia 48h OECD 202 |
|
|
Long term test performed as no effects were anticipated due to the low water solubility |
|
Algae 72h OECD 201 |
ErC50 = 44.3 µg/L |
ErC50 = 44.3 µg/L |
Reliability 1 Measured initial |
Scheerbaum, D. 2012 |
|
|
|
||
|
||||
Long term toxicity Daphnia 21d OECD 211 |
No sign. effects observed EL10 = 4.39 mg/L EC10 = ± 12.8 µg/L |
No sign. effects observed EL10 = 4.39 mg/L EC10 = ± 12.8 µg/L |
All endpoints Reliability 1 Loading Geomean measured |
Noack, M. 2012 |
|
||||
|
||||
Algae 72h OECD 201 |
ErC10 = 11.7 µg/L
|
ErC10 = 11.7 µg/L
|
Reliability 1 Measured initial |
Scheerbaum, D. 2012 |
|
|
|
Conclusion
Acute toxicity results are available for fish and algae. Long term toxicity results are available for aquatic invertebrates and algae. No significant effects were observed in the acute fish and long term daphnia test during exposure to the water accommodated fraction (WAF) of C36 -alkylenediamines. In the algae test significant effects were observed in the WAF. C36 -alkylenediamines is a strongly sorbing substance which sorbs strongly to algae during the test. According to the OECD guideline 201 (paragraph 40) it is acknowledged that quantification of such substances, particularly when low concentrations are concerned, quantification at the end of the study can be difficult. In such case, if the substance is stable under test conditions, the use of measured initial concentrations is considered acceptable.
For this reason it is considered justified to use the measured initial concentration to base the dose response on and not the mean measured concentration as most of the measured initial test substance concentration is actually either sorbed to algae or in the test solution.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.