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Diss Factsheets
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EC number: 232-192-9 | CAS number: 7789-82-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990-06-25 to 1990-07-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Guideline study under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- The study report states that the study was conducted in compliance with Good Laboratory Practice Standards, e.g. by the United Kingdom Compliance Programme, Department of Health & Social Security 1986 and subsequent revision, Department of Health, 1989.
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- disodium molybdate
- IUPAC Name:
- disodium molybdate
- Reference substance name:
- 7631-95-0
- Cas Number:
- 7631-95-0
- IUPAC Name:
- 7631-95-0
- Reference substance name:
- Disodium molybdate
- EC Number:
- 231-551-7
- EC Name:
- Disodium molybdate
- Cas Number:
- 7631-95-0
- Molecular formula:
- Na2MoO4
- IUPAC Name:
- 231-551-7
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): sodium molybdate
- Physical state: white crystalline powder
- Analytical purity: > 98.8% (calculated based on Molybdenum content of 46.03%)
- Impurities (identity and concentrations): no relevant impuritites were stated (>1%)
- Purity test date: 1990-06-06
- Storage condition of test material: At room temperature
No further significant information on test material was stated.
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- other: CD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: approximately seven to ten weeks
- Weight at study initiation: 216 to 262 g
- Housing: housed individually in metal cages with wire mesh floors. Each cage was identified by a coloured label displaying the dose level, study schedule number and the initials of the study director. Each animal was identified by cage number and ear punching.
- Diet (ad libitum): standard laboratory rodent diet (SDS LAD 1)
- Water (ad libitum): domestic quality potable water
- Acclimation period: 12 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): mean daily minimum and maximum temperatures were 22° C and 24°C respectively
- Humidity (%): mean daily relative humidity value was 60% RH
- Air changes (per hr): approximately 15 air changes/hour
- Photoperiod (hrs dark / hrs light): 12/12
No further significant information on test animals was stated.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- Sodium molybdate was prepared at a concentration of 177.8 % w/v in distilled water and administered at a volume of 1.12 ml/kg. The test substance was prepared on the day of dosing. One day prior to treatment hair was removed from the dorso-lumbar region of each rat with electric clippers exposing an area equivalent to 10% of the total body surface. No shaving or chemical depilation was used.
The test substance was applied by spreading it evenly over the prepared skin. The treated area (approximately 50 X50 mm) was then promptly covered with gauze which was held in place with an impermeable dressing encircled firmly around the trunk.
At end of the 24-hour exposure period, the dressings were carefully removed and the treated area of skin decontaminated by washing in warm (30°- 40° C) water and blotting dry with absorbent paper.
no other significant details stated. - Duration of exposure:
- 24-hour exposure period
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males, 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed soon after dosing and at frequent intervals for the remainder of day 1 (a period of four hours). On subsequent days the animals were observed once in the morning and again at the end of the experimental day. Clinical signs were recorded at each observation. The treated areas of skin were examined daily for signs of dermal irritation and scored according a scoring system.
SCORING SYSTEM:
Erythema and Eschar Formation:
no erythema = 0
slight erythema = 1
well-defined erythema = 2
moderate erythema = 3
serve erythema (beet redness) to slight eschar formation (injuries in depth) = 4
Oedema Formation:
no oedema = 0
slight oedema = 1
well-defined oedema (area well-defined by definite raising) = 2
moderate oedema 8raised approximately 1 millimetre) = 3
serve oedema (raised more than 1 millimetre and extending beyond the area of exposure) = 4
Individual bodyweights of rats was recorded on Days 1 (day of dosing), 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: The nature, severity, approximate time of onset and duration of each toxic sign were recorded. All animals on the study were killed on Day 15 by cervical dislocation and were subjected to a macroscopic post mortem examination which consisted of opening the abdominal and thoracic cavities. The macroscopic appearance of all examined tissues was recorded, and all livers and kidneys were preserved in buffered 10% formalin in order to satisfy any possible future requirements for further examination of these tissues.
No further significant details stated. - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: There were no signs of dermal irritation to any of the application sites.
- Mortality:
- No deaths following a single dose of Sodium molybdate at 2000 mg/kg bodyweight.
- Clinical signs:
- other: No signs of systemic reaction to treatment.
- Gross pathology:
- No results stated.
- Other findings:
- No further findings.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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