Registration Dossier
Registration Dossier
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EC number: 209-261-7 | CAS number: 563-76-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 1997
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-bromopropionyl bromide
- EC Number:
- 209-261-7
- EC Name:
- 2-bromopropionyl bromide
- Cas Number:
- 563-76-8
- Molecular formula:
- C3H4Br2O
- IUPAC Name:
- 2-bromopropanoyl bromide
- Test material form:
- other: Liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- 0.5 ml for 3 minutes
- Observation period:
- 72 hours
- Number of animals:
- 1 male
Results and discussion
In vivo
Results
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24 Hrs
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Corrosive to skin
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