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EC number: 617-084-5 | CAS number: 80474-45-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15th May 2003 - 30th April 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 14593
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: OPPTS 835.3120
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Test substance name: Thio Acid Propionate (CCI22363)
Chemical composition: 100%
Empirical formula: C24H30F2O5S
Appearance: White/ off white cystalline solid
Batch number: H030714
Receipt date: 26 April 2003
Storage Conditions: Room temperature (10 to 30°C) - Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- The activated sludge inoculum was not deliberately acclimatised or adapted to the test substance before exposure to the test substance before expoisure to the test substance in this study.
- Duration of test (contact time):
- ca. 28 d
- Initial conc.:
- 1.74 mg/L
- Based on:
- IC (inorganic carbon)
- Parameter followed for biodegradation estimation:
- inorg. C analysis
- Details on study design:
- Sample Preparation:
At each analysis point, duplicate vessels from each treatment group were removed from the orbital shaker. Sodium hydroxide solution (1mL at nominally 7M) was injected into each vessel through the butyl rubber stopper. The vessels were then returned to the orbital shaker and shaken for a period of at least one hour. The purpose of rendering the cultured alkaline in this way, was to fix all of the inorganic carbon present in the vessels into the liquid phase. The vessels were then removed from the shaker and allowed to stand to allow any sediment to settle. Samples were then removed from the liquid phase of each vessel for IC analysis. - Reference substance:
- benzoic acid, sodium salt
- Test performance:
- The mean inorganic carbon yield attributable to Thio Acid Propionate (CCI22363) was less than 1% of the initial organic carbon loading throughout the time course of this study. Although Thio Acid propionate (CCI22363) did not undergo significant mineralisation under the conditions employed in this study, this is not necessarily an indication that Thio Acid Propionate (CCI22363) would persist in the environment.
- Key result
- Parameter:
- % degradation (inorg. C analysis)
- Value:
- < 1
- Sampling time:
- 3 d
- Key result
- Parameter:
- % degradation (inorg. C analysis)
- Value:
- < 1
- Sampling time:
- 7 d
- Key result
- Parameter:
- % degradation (inorg. C analysis)
- Value:
- < 1
- Sampling time:
- 14 d
- Key result
- Parameter:
- % degradation (inorg. C analysis)
- Value:
- < 1
- Sampling time:
- 21 d
- Key result
- Parameter:
- % degradation (inorg. C analysis)
- Value:
- ca. 0
- Sampling time:
- 28 d
- Details on results:
- The ISO standard states that degradation of the reference substance should be at least 60% on the 14th day of incubation. Degradation of sodium benzoate was 90% on Day 14, thus satisfying this requirement, therefore the results of this study may be considered valid.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- The mean inorganic carbon yield attributable to Thio Acid Propionate (CCI22363) was less than 1% of the initial organic carbon loading throughout the time course of this study. Although Thio Acid Propionate (CCI22363) did not undergo significant mineralisation under the conditions employed in this study, this is not necessarily an indication that Thio Acid Propionate (CCI22363) would persist or accumulate in the environment.
- Executive summary:
The ultimate biodegradability of Thio Acid Propionate (CCI22363) was assessed by measuring the yield of inorganic carbon recovered under standard test conditions. The methods used were as described in ISO Standard 14593: Water quality - Evaluation of ultimate aerobic biodegradability of organic compounds in aqueous medium - Method by analysis of inorganic carbon in sealed vessels (CO2headspace test), and is essentially the same as that described in US EPA Guideline OPPTS 835.3120.
The mean inorganic carbon yield attributable to Thio Acid Propionate (CCI22363) was less than 1% of the intial organic carbon loading throught the time course of this study. Although Thio Acid Propionate (CCI22363) did not undergo significant minerlisation under the conditions employed in this study, this is not necessarily an indication that Thio Acid Propionate (CCI22363) would persist or accumulate in the environment. The mean inorganic carbon yield attributable to the reference substance, sodium benzoate, exceeded 90% of the initial organic carbon loading on Days 14 and 28. These data satisfy the validity criteria stated in the ISO standard, and show that the microbial inoculum employed was exerting normal degradative activity.
Reference
Inorganic Carbon Analytical Data:
Level of Inorganic Carbon (ppm) at Time (days) | ||||||
3 | 7 | 14 | 21 | 28 | ||
Control #1 | 1.487 | 1.749 | 1.909 | 2.590 | 2.618 | |
Control #2 | 1.565 | 1.875 | 1.808 | 2.674 | 2.499 | |
Mean Control | 1.526 | 1.812 | 1.858 | 2.632 | 2.558 | |
Level of Inorganic Carbon (ppm) at Time (days) | ||||||
3 | 7 | 14 | 21 | 28 | ||
Test #1 | 0 | 0.043 | 0.152 | 0 | 0 | |
Test #2 | 0.041 | 0.071 | 0.080 | 0.045 | 0 | |
Reference #1 | 9.632 | 11.688 | 13.431 | 13.240 | 13.939 | |
Reference #2 | 9.325 | 12.152 | 13.849 | 13.210 | 13.992 |
Description of key information
Test vessels were filled with inoculated mineral salts medium, with or without the test refernce substances, to provide a liquid-to-headspace ratio of 2:1. The vessels were sealed and incubated with shaking for 28 days in darkness. At intervals replicate vessels from each treatment group were rendered alkaline to fix inorganic carbonates and to absorb CO2from the headspace into the medium. The inorganic carbon yield in each vessel was then determined by carbon analysis.
Inorganic carbon (IC) yields for vessels in the test and reference groups were corrected for the IC content of control vessels containing unamended mineral medium. The extent of biodegradation was calculated by expressing the blank corrected IC yield in test vessels as a percentage of the organic carbon loading from the test substance added at the start of the test. The procedure and the activity of the inoculum were checked by a set of test vessels containing the readily degradable reference substance sodium benzoate.
The study was initialted (protocol issued) on 15 May 2003, and completed (final report issued) on 30 April 2004. It was conducted in the Ecotoxicological Section of the Department of Environmental Sciences, Covance, Harrogate, North Yorkshire, England. The test subtance was dosed to the test system on 28 August 2003, and the practical phase was completed on 16 October 2003.
Test Medium:
The test was conducted in an aqueous synthetic mineral salts medium. On Day 0 of the test, test medium was prepared so that the final concentration established in test systems would be equivalent to 10mL/L solution (a) and 1mL/L of each of solutions (b), (c) and (d). Solutions (a) to (d) were nominally composed as follows:
(a):8.50g potassium dihydrogen phophate (Fisher); 21.75g dipotassium hydrogen phosphate (BDH); 33.4g disodium hydrogen phosphate dihydrate (Fisher); 0.50g ammonium chloride (Sigma), all dissolved in and made up to 1L with reverse-osmosis water.
(b):36.4g calcium dissolved in and made up to 1L with reverse-osmosis water.
(c):22.5g magnesium sulphate heptahydrate (Fisher), dissolved in and made up to 1L with reverse-osmosis water.
(d):0.25g ferric chloride hexahydrate (Aldrich) plus one drop concentrated hydrochloric acid (BDH); dissolved in and made up to 1L with reverse-osmosis water.
On the basis of the suspended solids determination described above, the medium was inoculated with activated sludge to provide a nominal final solids concentration of 4mg/L.
The medium was dispensed into "125"mL glass serum bottles, which have an approximate total volume of 160mL. Aliquots of 100ml were initially dispensed into each bottle. The remaining 7mL to be added comprised reference substance stock solution and/or reverse-osmosis water, depending on the treatment group.
Dosing the Reference Substance:
Based on the molecular formula of sodium benzoate, its carbon content expressed as a percentage by weight is 58.3%. This value was used in setting the concentration of sodium benzoate to be applied in this study. A level of 15mgC/L is achieved from a stock sodium benzoate concentration of 0.5506g/L dosed at a dilution of 5mL in 107mL. The stock was prepared by dissolving 55.1mg of sodium benzoate in 100mL of reverse-osmosis water, and this stock was added (5ml) to vessels in that refernce group, to give a nominal reference substance concentration corresponding to 15mgC/L.
Dosing the Test Substance:
The test substance was sufficiently soluble to permit dosing of the test system with a concentration aqueous stock solution. The test substance was therefore added directly to vessels in the test group. Based on the molecular formula of the test substance provided by the Sponsor, the carbon content of Thio Acid Propionate (CCI22363) [1.74mg +/- 0.03mg] was added to vessels in the test group to achieve a final nominal concentration of 10mgC/L.
Incubation Conditions:
The incubation and test measurements were conducted in a facility where the temperature was maintained at a nominal 21°C. Temperatures recorded during the study fell between 19.8°C and 20.8°C, and were essentially comliant with the test Guideline requirement that the termperature be maintained in the range 20 to 25°C, with the overall variation not exceeding +/- 2°C.
Test substance name: Thio Acid Propionate (CCI22363)
Chemical composition: 100%
Empirical formula: C24H30F2O5S
Appearance: White/ off white cystalline solid
Batch number: H030714 Receipt date: 26 April 2003
Storage Conditions: Room temperature (10 to 30°C)
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
The ultimate biodegradability of Thio Acid Propionate (CCI22363) was assessed by measuring the yield of inorganic carbon recovered under standard test conditions. The methods used were as described in ISO Standard 14593: Water quality - Evaluation of ultimate aerobic biodegradability of organic compounds in aqueous medium - Method by analysis of inorganic carbon in sealed vessels (CO2headspace test), and is essentially the same as that described in US EPA Guideline OPPTS 835.3120.
The mean inorganic carbon yield attributable to Thio Acid Propionate (CCI22363) was less than 1% of the intial organic carbon loading throught the time course of this study. Although Thio Acid Propionate (CCI22363) did not undergo significant minerlisation under the conditions employed in this study, this is not necessarily an indication that Thio Acid Propionate (CCI22363) would persist or accumulate in the environment. The mean inorganic carbon yield attributable to the reference substance, sodium benzoate, exceeded 90% of the initial organic carbon loading on Days 14 and 28. These data satisfy the validity criteria stated in the ISO standard, and show that the microbial inoculum employed was exerting normal degradative activity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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