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EC number: 210-578-8 | CAS number: 619-08-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from Handbook
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Toxicology of Drugs and Chemicals
- Author:
- William B. Deichmann and Horace W. Gerarde
- Year:
- 1 969
- Bibliographic source:
- Toxicology of Drugs and Chemicals, P. 169, 1969
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity of 2-chloro-4-nitrophenol (619-08-9)
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 012
- Bibliographic source:
- Sax's Dangerous Properties of Industrial Materials. 12th Edition, 2012
- Reference Type:
- secondary source
- Title:
- INITIAL SUBMISSION: TOXICOLOGICAL INVESTIGATION OF 2-CHLOR0-4-NITROPHENOL WITH COVER LETIER DATED 081392
- Author:
- National Technical Reports Library
- Year:
- 1 992
- Bibliographic source:
- INITIAL SUBMISSION: TOXICOLOGICAL INVESTIGATION OF 2-CHLOR0-4-NITROPHENOL, OTS0570573, 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as metioned below
- Principles of method if other than guideline:
- Acute oral toxicity of 2-chloro-4-nitrophenol (619-08-9) in albino rats.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2-chloro-4-nitrophenol
- EC Number:
- 210-578-8
- EC Name:
- 2-chloro-4-nitrophenol
- Cas Number:
- 619-08-9
- Molecular formula:
- C6H4ClNO3
- IUPAC Name:
- 2-chloro-4-nitrophenol
- Details on test material:
- - IUPAC Name: 2-chloro-4-nitrophenol
- Common Name: Nitrofungin
- Mol. formula: C6H4ClNO3
- Molecular Weight: 173.555 g/mol
- Smiles: c1(cc(c(O)cc1)Cl)[N+](=O)[O-]
- InChI: 1S/C6H4ClNO3/c7-5-3-4(8(10)11)1-2-6(5)9/h1-3,9H
Constituent 1
- Specific details on test material used for the study:
- - IUPAC Name: 2-chloro-4-nitrophenol
- Common Name: Nitrofungin
- Mol. formula: C6H4ClNO3
- Molecular Weight: 173.555 g/mol
- Smiles: c1(cc(c(O)cc1)Cl)[N+](=O)[O-]
- InChI: 1S/C6H4ClNO3/c7-5-3-4(8(10)11)1-2-6(5)9/h1-3,9H
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Diet (e.g. ad libitum): Diet was provided to the rats.
Administration / exposure
- Route of administration:
- other: Stomach tube
- Vehicle:
- corn oil
- Remarks:
- 50%
- Details on oral exposure:
- - Concentration in vehicle: 700, 800, 900, and 1000 mg/kg
- Doses:
- 700, 800, 900, and 1000 mg/kg
- No. of animals per sex per dose:
- Total = 23 (Male/Female)
700 mg/ kg – 3 Males and 2 Females
800 mg/ kg – 3 Males and 2 Females
900 mg/ kg – 4 Males and 4 Females
1000 mg/ kg – 2 Males and 3 Females - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: No data
- Frequency of observations and weighing: Weighing was performed.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology, examinations were observed. - Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 900 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed.
- Mortality:
- 50% mortality was observed at 900 mg/kg bw
- Clinical signs:
- other: Excessive salivation and moderate diarrhea was observed in animals those are survived overnight period after dosing.
- Gross pathology:
- Liver damage was observed after macroscopic examination.
- Other findings:
- not specified
Any other information on results incl. tables
Table – The Acute Oral Toxicity (LD50) of 2-chloro-4-nitrophenol for rats.
Animal No. - Sex |
Weight Gm |
Dose Mg/kg |
Fate |
1 – Male |
240 |
700 |
Survived |
2 - Female |
200 |
700 |
Survived |
3 - Female |
195 |
700 |
Died |
4 – Male |
225 |
700 |
Died |
5 – Male |
250 |
700 |
Survived |
6 - Male |
215 |
800 |
Died |
7 - Male |
230 |
800 |
Survived |
8 - Male |
245 |
800 |
Survived |
9 - Female |
200 |
800 |
Died |
10 - Female |
210 |
800 |
Survived |
11 - Female |
220 |
900 |
Died |
12 – Male |
248 |
900 |
Survived |
13 - Male |
220 |
900 |
Survived |
14 - Female |
210 |
900 |
Died |
15 - Female |
190 |
900 |
Died |
16 - Female |
208 |
900 |
Survived |
17 - Male |
230 |
900 |
Survived |
18 - Male |
260 |
900 |
Died |
19 - Male |
245 |
1000 |
Died |
20 - Female |
200 |
1000 |
Died |
21 - Female |
200 |
1000 |
Died |
22 - Female |
225 |
1000 |
Died |
23 - Male |
240 |
1000 |
Died |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD50 was considered to be 900 mg/kg bw, when Sprague dawley rats were treated with 2-chloro-4-nitrophenol (619-08-9) orally.
- Executive summary:
The acute oral toxicity of 2-chloro-4-nitrophenol was tested in 23 Sprague dawley Male and Female rats by administering the test substance through stomach tube. The dose concentrations used were 700, 800, 900 and 100mg/kg in 50% suspension in corn oil (Vehicle). Diet was provided to the rats. Rats were observed for clinical signs, body weight, organ weights, and histopathology, examinations. 50% mortality was observed in treated rats. During the observation period of several days, Excessive salivation and moderate diarrhea was observed in animals those are survived overnight period after dosing. Body weight was noted in Table for all the animals. Liver damage was observed after macroscopic examination. Therefore, LD50 was considered to be 900 mg/kg bw, when Sprague dawley rats were treated with 2-chloro-4-nitrophenol (619-08-9) orally.
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