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EC number: 235-841-4 | CAS number: 13003-12-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Butylidenebis[2-tert-butyl-5-methyl-p-phenylene]-P,P,P',P'-tetratridecylbis(phosphine)
- EC Number:
- 235-841-4
- EC Name:
- Butylidenebis[2-tert-butyl-5-methyl-p-phenylene]-P,P,P',P'-tetratridecylbis(phosphine)
- Cas Number:
- 13003-12-8
- Molecular formula:
- C78H144O6P2
- IUPAC Name:
- 4-[2-(4-{[bis(tridecyloxy)phosphanyl]oxy}-5-tert-butyl-2-methylphenyl)pentyl]-5-methyl-2-(propan-2-yl)phenyl ditridecyl phosphite
- Test material form:
- liquid
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA:J
- Sex:
- female
- Details on test animals and environmental conditions:
- Acclimatisation
After veterinary examination for good health, the mice were received into the experimental procedure room and allowed to acclimatise to the laboratory conditions for a minimum period of 5 days. During the acclimatisation period, the mice were observed daily for any clinical signs of disease. Following acclimatisation, the mice will be rechecked prior to allocation to the study.
Housing
Animals were housed in solid floor polypropylene mouse cages (size: 290 mm x 220 mm x 140 mm). Each cage was fitted with a top grill having provision for keeping rodent pellet feed and a polypropylene water bottle with a stainless steel drinking nozzle. During acclimatisation the animals were housed in group (5 mice/cage). On the day of first test item application (Day 0) and on days 1 and 2, the animals were housed in individual cages. From day 3 the animals were group-housed 5 mice/cage.The bottom of the cages were layered with clean sterilized the bedding material. On day 5 post-administration of the radio labelled material, the animals were transferred to the metal metabolic cages.
Study design: in vivo (LLNA)
- Vehicle:
- methyl ethyl ketone
- Concentration:
- 5%, 25% and 50% (v/v) in methyl ethyl ketone (MEK)
- No. of animals per dose:
- 5
- Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
- Positive control results:
- Positive control was valid with a SI=6.23
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Value:
- 1.43
- Test group / Remarks:
- 5%
- Parameter:
- SI
- Value:
- 2.22
- Test group / Remarks:
- 25%
- Parameter:
- SI
- Value:
- 2.66
- Test group / Remarks:
- 50%
Any other information on results incl. tables
Group N° |
Dose Concentration |
N° of Mice Used |
Group Mean DPM |
Standard Deviation |
Stimulation Index (SI) |
G1 |
Vehicle (MEK) |
5 |
1314.00 |
341.78 |
1 |
G2 |
5% (v/v) Butylidenebis[2-tert-butyl-5-methyl-p-phenylene]-P,P,P’,P’-tetratridecylbis (phosphine) |
5 |
1879.20 |
260.56 |
1.43 |
G3 |
25% (v/v) Butylidenebis[2-tert-butyl-5-methyl-p-phenylene]-P,P,P’,P’-tetratridecylbis (phosphine) |
5 |
2923.60 |
654.96 |
2.22 |
G4 |
50% (v/v) Butylidenebis[2-tert-butyl-5-methyl-p-phenylene]-P,P,P’,P’-tetratridecylbis (phosphine) |
5 |
3498.60** |
700.25 |
2.66 |
G5 |
25% (v/v) HCA |
5 |
8186.00** |
1835.96 |
6.23 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results of the LLNA study, the test substance was determined not to be a skin sensitiser.
- Executive summary:
Based on the results of the LLNA study, the test substance was determined not to be a skin sensitiser.
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