Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 936-211-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Study period:
- 04 September 2018 - 05 November 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- During method development, the test item was found to be insoluble in water, n-octanol, the typical HPLC solvents, methanol, acetonitrile, tetrahydrofuran, and dichloromethane and hexane.
Therefore, the partition coefficient (Pow) of the test item was predicted using the computerbased prediction software, KOWWIN, v1.68 (September 2010), © 2000. U.S. Environmental Protection Agency - Qualifier:
- according to guideline
- Guideline:
- other: KOWWIN, v1.68
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- calculation method (fragments)
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- 6.73
- Remarks on result:
- other: Magnesium hydroxide stearate component
- Key result
- Type:
- log Pow
- Partition coefficient:
- 7.48
- Remarks on result:
- other: Aluminium hydroxide stearate component.
- Conclusions:
- Using KOWWIN v1.68, the log10 partition coefficient (log10 Pow) of the test item was predicted to be 6.73 for the Magnesium hydroxide stearate component and 7.48 for the Aluminium hydroxide stearate component.
- Executive summary:
Testing according to the shake-flask method and HPLC-Method of Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Methods 107 and/or 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 was considered to be non-feasible because during method development, the test item was found to be insoluble in water, n-octanol, the typical HPLC solvents, methanol, acetonitrile, tetrahydrofuran, and dichloromethane and hexane.
Therefore, the partition coefficient (Pow) of the test item was predicted using the computerbased prediction software, KOWWIN, v1.68 (September 2010), © 2000. U.S. Environmental Protection Agency.
Using KOWWIN v1.68, the log10 partition coefficient (log10 Pow) of the test item was predicted to be 6.73 for the Magnesium hydroxide stearate component and 7.48 for the Aluminium hydroxide stearate component.
Reference
Description of key information
Testing according to the shake-flask method and HPLC-Method of Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Methods 107 and/or 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 was considered to be non-feasible because during method development, the test item was found to be insoluble in water, n-octanol, the typical HPLC solvents, methanol, acetonitrile, tetrahydrofuran, and dichloromethane and hexane.
Therefore, the partition coefficient (Pow) of the test item was predicted using the computerbased prediction software, KOWWIN, v1.68 (September 2010), © 2000. U.S. Environmental Protection Agency.
Using KOWWIN v1.68, the log10 partition coefficient (log10 Pow) of the test item was predicted to be 6.73 for the Magnesium hydroxide stearate component and 7.48 for the Aluminium hydroxide stearate component.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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