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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-321-6 | CAS number: 105-67-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Based on the harmonised classification under Annex VI of the CLP Regulation (EC) No. 1272/2008 (index no. 604 -006 -00 -x, ATP0), the test substance is considered to be toxic via oral and dermal routes.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Key result
- Dose descriptor:
- LD50
- Remarks:
- Rat
- Effect level:
- 3 200 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 780 - 3 680
- Remarks on result:
- other: apathy, lying on the side, respiratory arrest (no further details)
- Remarks:
- LD50 value from Uschdavini et al., 1974, 1979 studies cited in BG RCI, 2005 report
- Key result
- Dose descriptor:
- LD50
- Remarks:
- Mouse
- Effect level:
- 809 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 724 - 914
- Remarks on result:
- other: apthy, lying on the side, respiratory arrest
- Remarks:
- LD50 value from Uschdavini et al., 1974, 1979 studies cited in BG RCI, 2005 report
- Key result
- Dose descriptor:
- LD50
- Remarks:
- Mouse
- Effect level:
- > 1 000 - <= 1 250 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no deaths; curved position and reeling at 1000 mg/kg bw/day; deaths at 1250 mg/kg bw
- Remarks:
- LD50 value from BASF, 1998b study cited in BG RCI, 2005 report
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Based on literature sources, the LD50 values were reported to be 3500 mg/kg bw in rats and ranged from 809 to 1250 mg/kg bw/day in mice.
- Executive summary:
The BG RCI report on test substance reported three acute toxicity studies conducted in rats and mice. The LD50 values were reported to be 3500 mg/kg bw in rats and ranged from 809 to 1250 mg/kg bw/day in mice (BG RCI, 2005).
.
- Endpoint:
- acute toxicity: oral
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
- Reason / purpose for cross-reference:
- data waiving: supporting information
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 250 mg/kg bw
- Quality of whole database:
- Literature data cited in BG RCI report
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Data waiving: In accordance with Annex VII, Section 8.5, Column 2, an acute toxicity study does not need to be conducted because the substance is classified as corrosive to the skin.
Literature data available on the test substance reported the LD50 values as 3500 mg/kg bw in rats and 809 to 1250 mg/kg bw/day in mice (BG RCI, 2005).
Justification for classification or non-classification
The test substance has a ‘Acute Tox. 3 ; H301: Toxic if swallowed' and 'Acute Tox. 3; H11: Toxic in contact with skin' harmonised classification under the EU CLP (Regulation EC 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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