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Diss Factsheets
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EC number: 206-007-7 | CAS number: 286-20-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
SKIN IRRITATION/CORROSION
Based on the weight of evidence approach, the test material was determined to cause severe damage and be highly corrosive to the skin.
EYE IRRITATION
Based on the weight of evidence approach, the test material was determined to cause serious eye damage, and be highly corrosive.
RESPIRATORY IRRITATION
Based on a weight of evidence approach, the test material was determined to cause respiratory irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study report is presented in an abstract; very little information is available regarding the method of exposure. It is therefore not possible to assess the accuracy of the data.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Irritation and corrosivity observations were performed as part of an aucte dermal toxiicty study. The test material was held in prolonged contact with the skin of a rabbit and the resultant skin reaction was noted.
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- The test animal was exposed for 24 hrs.
- Remarks on result:
- other: Under the conditions of the study, the test material was shown to cause a severe reaction to the skin, leaving chemical like burns.
- Irritant / corrosive response data:
- Exposure to the test material resulted in moderate to severe chemical burns.
- Other effects:
- The LD50 of the test material was greater than 1000 mg/kg bw.
- Interpretation of results:
- highly corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Under the conditions of the study, the test material was shown to cause a severe reaction to the skin, leaving chemical like burns.
- Executive summary:
The irritation potential of the test material to the skin was determined in an unspecified species of rabbit. The study records that moderate to severe chemical burns were caused as a result of dermal exposure over a 24 hour period. There is no available information regarding the methods used, so it is not possible to assess the accuracy of the data from the available information.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Not reported.
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The data was presented in very limited detail and so it was not possible to assess the accuracy of the data from the information presented.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Various volumes of test material, in water or propylene glycol, were instilled in the eye of rabbits. Eye reactions were observed and graded according to the 10-grade ordinal series based upon the degree of resultant corneal necrosis. The methodology is reported in Smyth et al (1962).
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- other: water or propylene glycol
- Controls:
- not specified
- Amount / concentration applied:
- The test material was dosed in a 1% solution in water or propylene glycol. The volume and concentration both varied.
- Details on study design:
- Scored against a 10-grade ordinal series, bases on the degree of corneal necrosis.
Grade 1 - a very small area of necrosis resulting from 0.5 mL of undiluted chemical
Grade 5 - severe burn from 0.005 mL
Grade 10 - severe burn form 0.5 mL of a 1% solution in water or propylene. - Irritation parameter:
- cornea opacity score
- Basis:
- other: not reported.
- Score:
- 8
- Max. score:
- 10
- Remarks on result:
- other: No data available for the time point, max. score or reversibility.
- Interpretation of results:
- highly corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Under the conditions of the test a strong response was seen in the cornea of the test animals, which permits classification as highly corrosive by expert judgement.
- Executive summary:
Various volumes of test material, in water or propylene glycol, were instilled in the eye of rabbits. Eye reactions were observed and graded according to the 10-grade ordinal series based upon the degree of resultant corneal necrosis. Under the conditions of the test a strong response was seen in the cornea of the test animals, which permits classification as highly corrosive by expert judgement.
Reference
No further information on results is reported.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
SKIN IRRITATION
Three studies and a material safety data sheet have been provided to address this endpoint on a weight of evidence basis.
Smyth (1969) described the test material as being irritating to the skin and was scored 3 on a 10-grade scoring system. The safety data sheet from Alfa Aesar (1975) described the test material as irritating and corrosive to the skin. Pullin (1957) and Fougler (1948) do not provide sufficient information to derive a classification however they support the finding that the test material is irritating and corrosive providing the following observations respectively; severe chemical burns and erythema. All studies have been assigned a reliability score of 4 according to the principles for assessing data quality in Klimisch (1977). The general consensus presented is that the test material is highly irritating and corrosive in the event of contact with the skin and is classified on a worst case basis.
EYE IRRITATION
Two studies and a safety data sheet have been provided to address this endpoint using the weight of evidence approach. Smyth (1969) reports a strong corneal response. Pullin (1975) observed corneal injury, moderate pain, conjunctiva inflammation and slight iritis post exposure. The safety data sheet from Alfa Aesar (1975) described the effects of the test material as an eye irritant and strong corrosive. The general consensus described in the weight of evidence is that the test material is highly irritating and corrosive. All the studies are reported as abstracts and do not mention methods. The reliability of all three sources has been assigned a reliability score of 4, according to the principles for assessing data quality set out in Klimisch (1977). There is sufficient consistency between the sources to act as a weight of evidence, and the consensus is that the test material causes irritation and corrosion when in contact with the eyes.
RESPIRATORY IRRITATION
Respiratory irritation has been observed during acute inhalation toxicity tests; Pullin (1975) and Foulger (1948). Both studies have been
assigned a reliability score of 4, according to the principles for assessing data quality set out in Klimisch (1977).
Justification for selection of skin irritation / corrosion endpoint:
The endpoint was selected since it displayed the most severe skin reaction following exposure to the test material. The study was selected as the worst case scenario.
Justification for selection of eye irritation endpoint:
The endpoint was selected since it displayed the most severe eye reaction following exposure to the test material. The study was selected as the worst case scenario.
Effects on skin irritation/corrosion: highly corrosive
Effects on eye irritation: highly corrosive
Effects on respiratory irritation: irritating
Justification for classification or non-classification
SKIN IRRITATION
The skin irritation studies indicate that the test material is highly irritating and corrosive. A classification under Regulation directive 1272/2008 of "Category 1B, H314: Causes severe skin burns and eye damage”, and signal word “Danger” is taken forward for risk assessment as a worst case basis.
EYE IRRITATION
The eye irritation studies indicate that the test material is highly irritating and corrosive. A classification under Regulation 1272/2008 of "Category 1 eye damage, H318: Causes serious eye damage”, and signal word “Danger” is taken forward for risk assessment as a worst case basis..
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