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Diss Factsheets
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EC number: 429-280-6 | CAS number: 151900-44-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (e.g. rel. low purity of test substance 86.3%)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 402
- GLP compliance:
- yes
- Test type:
- other: acute dermale toxicity
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 429-280-6
- EC Name:
- -
- Cas Number:
- 151900-44-6
- Molecular formula:
- Hill formula: C36H40N2S6 CAS formula: C36H40N2S6
- IUPAC Name:
- N,N-dibenzyl({6-[(dibenzylcarbamothioyl)disulfanyl]hexyl}disulfanyl)carbothioamide
- Details on test material:
- purity: 86.3%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Bor: WISW (SPF Cpb)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:
- Age at study initiation: Winkelmann Co, 4799 Borchen
- Weight at study initiation: 200-300 g
- Fasting period before study:
- Housing:separated by sex, max. 5 animals per Makrolon type III cage
- Diet:ad libitum
- Water: ad libitum
- Acclimation period: at least 5 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3°C
- Humidity (%): 30-70%
- Photoperiod (12hrs dark / 12hrs light)
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- corn oil
- Details on dermal exposure:
- TEST SITE
- Area of exposure: intact dorsal skin, 6.67 cm3/kg bw
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes with corn oil MEH 56
- Duration of exposure:
- 4 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5/sex
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 1/2, 1, 2, 3, 4, 5, and 6 h post application as well as once daily during the following 14 days
- Frequency of observations and weighing: day 0, day 7, day 14
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: Substanzbedingte Vergiftungssymptome traten nicht auf. Alle Tiere zeigten während der 14tägigen Beobachtungsperiode eine normale Körpergewichtsentwicklung. "ENGLISH" No substance related symptoms of toxicit
- Gross pathology:
- Effects on organs:
Keine Hinweise auf substanzbedingte Organveränderungen bei
den Sektionen und makroskopischen Untersuchungen.
"ENGLISH"
No indications of substance related changes of the organs
occured during the sections and macroscopic investigations. - Other findings:
- Signs of toxicity (local):
Es traten weder bei den männlichen noch bei den weiblichen
Tieren substanzbedingte Vergiftungserscheinungen auf. Im
Applikationsbereich wurde 72 h nach Substanzverabreichung
bei drei weiblichen Tieren Schuppenbildung auf der Haut
beobachtet; zwei Tiere zeigten zusätzlich eine Hautrötung.
Nach Ablösung der Schuppen am 7. Tag post applicationem (2
Tiere), am 9. Tag post applicationem (1 Tier) stellte sich
die Applikationsfläche ohne Befund dar. Fünf männliche und
zwei weibliche Tiere zeigten zu keinem Beobachtungszeitpunkt
eine Hautveränderung.
"ENGLISH"
Neither the male nor the female animals showed substance
related symptoms of toxicity.
72 hours after the application of the substance three female
test animals showed scale formation of the skin in the
application range; two animals showed as well redness of the
skin. After the scales came off after the application
(7. day 2 animals, 9. day 1 animal the treated area was
without any findings. Five male and two female animals never
showed changes of the skin during the observation period.
Any other information on results incl. tables
Mortality:
Male: 2000 mg/kg bw; 0/5; females 0/5
Clinical Signs:
No substance related symptoms of toxicity occured. All animals showed a normal body weight development during the observation period.
Gross pathology:
No indications of substance related changes of the organs occured during the sections and macroscopic investigations.There were no changes of the skin or in the subcutaneous tissue in the region of application.
Other findings:
72 hours after the application of the substance three female test animals showed scale formation of the skin in the application range; two animals showed as well redness of the skin. After the scales came off after the application (7. day 2 animals, 9. day 1 animal the treated area was without any findings. Five male and two female animals never showed changes of the skin during the observation period.
Applicant's summary and conclusion
- Executive summary:
In rats the LD50 after dermal exposure was >2000 mg/kg bw. This dermal acute toxicity study was done under GLP according to OECD guideline 402 (Hüls AG 1992b). No effects were observed with regard to mortality, clinical signs, body weight and gross examinations. However, scale formation in the region of application was observed in three of five animals 72 hours post application. This effect was reversible within 9 days. In addition, two of these animals showed skin redness 72 hours after the application. Although,
no changes of the skin or in the subcutaneous tissue in the application area were found in any of the animals.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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