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Diss Factsheets
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EC number: 203-874-3 | CAS number: 111-48-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is comparable to OECD Guideline 401 with acceptable restrictions (partly limited documentation, e.g. no details about the test substance; post exposure period 7 days [but no later deaths expected]; no data about body weight)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Thiodiglycol
- EC Number:
- 203-874-3
- EC Name:
- Thiodiglycol
- Cas Number:
- 111-48-8
- Molecular formula:
- C4H10O2S
- IUPAC Name:
- 2-[(2-hydroxyethyl)sulfanyl]ethan-1-ol
1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Body weight at initiation: 176 - 294 g (range)
No further details.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Application of up to 40% aqueous solution; no data about fasting prior to application. Vehicle: Doubly distilled water.
- Doses:
- The doses above were administered as aqueous solution of 2% (200 µl/kg bw), 20% (1600 µl/kg bw), 30% (3200 and 6400 µl/kg bw) and 40% (8000 and 10000 µI/kg bw) test substance in water, respectively.
- No. of animals per sex per dose:
- 5 males and 5 females per dose
- Control animals:
- no
- Details on study design:
- Group-wise documentation of clinical signs was performed over the 7- 8-day study period. Body weight was determined before the start of the study for determination of dose.
On the basis of the observed lethality, the LD50 value was estimated or determined using a graphical evaluation of the dose response curve on probability paper. - Statistics:
- LD50 estimated
Results and discussion
- Preliminary study:
- no data
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 10 mL/kg bw
- Remarks on result:
- other: LD50 for males and females combined
- Mortality:
- 200, 1,600, and 3,200 µI/kg bw: no deaths
6400 µI/kg bw: 1 male died within 4 days, 1 female died within the first 24 hours and another female died within 6 days
8000 µI/kg bw: no males died, 3 females died within the first 48 hours
10000 µI/kg bw: no males died, all females died within the first 24 hours - Clinical signs:
- other: 10000 and 8000 µI/kg bw: staggering, dyspnoea immediately after application, exophthalmus, slight peripheral hyperemia, reddish eyes, reduced attention, polyuria, motor excitation, squatting posture, piloerection, eyelid closure and crusts until including
- Gross pathology:
- Animals that died after 10000, 8000 and 6400 µI/kg bw: hemorrhage in the pancreas, soft feces, dark urine or no abnormalities.
Animals examined at termination of the study at 6400, 3200, 1600 and 200 µI/kg bw: Organs without particular findings (no data about males in the high dose group). - Other findings:
- no data
Any other information on results incl. tables
No estimation of LD50 only for males.
Applicant's summary and conclusion
- Conclusions:
- In male and female rats combined the oral LD50 is appr. 10000 µl/kg bw corresponding to 11800 mg/kg bw.
- Executive summary:
The study is comparable to OECD Guideline 401 with acceptable restrictions (partly limited documentation, e.g. no details about the test substance; post exposure period 7 days [but no later deaths expected]; no data about body weight).
Groups of 5 male and 5 female rats were gavaged with 2 - 40% aqueous solutions at dose levels of 200, 1600, 3200, 6400, 8000, and 10000 µl/kg bw. The post exposure observation period was 7 days. Clinical signs like staggering, dyspnoea immediately after application, exophthalmus, slight peripheral hyperemia, reddish eyes, reduced attention, polyuria, motor excitation, squatting posture, piloerection, and eyelid closure occurred and were reversible at the end of the post exposure observation period. Mortality was evident at >= 6400 µl/kg bw. Females were more sensitive than males. Necropsy revealed several rats with pancreas bleeding.
Conclusion: In male and female rats combined the oral LD50 is appr. 10000 µl/kg bw corresponding to 11800 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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