Registration Dossier
Registration Dossier
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EC number: 233-823-0 | CAS number: 10377-52-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Concerning skin irritation, there is one GLP guideline study available with trilithium orthophosphate itself (BASF 2012), revealing no skin irritating properties of the test substance.
With regard to this endpoint, the lithium ion is considered to be the main toxophore, as phosphate ions are widely distributed throughout the organism (e.g. as structural material of bone and teeth and in form of adenosine phosphates ADP and ATP).
With regard to the fact, that trilithium orthophosphate is slightly soluble in water (0.27 g/L), read-across to a more soluble lithium salt (representing a higher bioavailability) can be justified. However, for the endpoint "eye irritation", read-across was also performed to another alkali phosphate (Trisodium orthophosphate).
There is one study summary for Lithium chloride (CAS# 7447-41-8) publicly available on the homepage of the ECHA (European Chemicals Agency; disseminated dossier for Lithium chloride). This study was performed according to OECD Guideline 404. It is concluded that the test material is not irritating according to GHS criteria.
Another study summary for Lithium carbonate (CAS# 554-13-2; disseminated dossier for Lithium chloride; ECHA homepage) is publicly available and the overall conclusion of this study (according to OECD TG 404) is, that the test material is not irritating to skin according to GHS criteria.
For the endpoint “eye irritation”, read-across was performed to Lithium chloride (CAS# 7447-41-8), Lithium carbonate (CAS# 554-13-2) and to trisodium orthophosphate (CAS# 7601-54-9). All the information is publicly available on the ECHA homepage (disseminated dossiers for Lithium chloride, Lithium carbonate and trisodium orthophosphate). Lithium chloride and Lithium carbonate are considered to be irritating to eyes (Cat. 2) according to GHS criteria. Trisodium orthophosphate is considered to be an eye irritant under the grading system as outlined in the Federal Substances Labelling Act.
Based on a GLP guideline study in vitro (BASF 2012), trilithium orthophosphate is not classified for skin irritation. Trilithium orthophosphate is classified as Xi, R36, irritating to eyes in accordance to Directive 67/548/EEC; Eye irritation Cat. 2A, H319, causes serious eye irritation in accordance to EU CLP (Regulation (EC) No. 1272/2008) and UN GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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