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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 208-793-7 | CAS number: 541-85-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 10.759 mg/m³
- Most sensitive endpoint:
- developmental toxicity / teratogenicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 264.474 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- NOAEC=NOAELoral_rat/(AF1*AF2*AF3)=300/(0.38*2.0*1.5)=264.474 mg/m³. Three AF were used for the extrapolation from the oral to the inhalation route: 1) AF1=0.38 to convert oral NOAELrat_rat (in mg/kg bw/day) into inhalatory NOAECinhal_rat (in mg/m3) by using a default respiratory volume for the rat corresponding to the daily duration of human exposure (Table R. 8-2 p.20), 2) AF2=2.0 to correct for differences in absorption between routes (it is assumed that the absorption percentage for the starting route is half that of the end route in the case of oral-to inhalation extrapolation in the absence of substance specific data on absorption via the different routes. R8, p.19), 3) AF3=1.5 to correct for the difference between respiratory rates under standard conditions and under conditions of light activity for workers (Table R. 8-2 p.20). [1.5 from 10 m3 per worker divided by 6.7 m3 per person].
- AF for dose response relationship:
- 1
- Justification:
- Default assessment factor, as a standard procedure, is 1. (R8, p.30).
- AF for differences in duration of exposure:
- 2
- Justification:
- sub-chronic to chronic (Table R. 8-5 p.29)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allometric scaling (AS) from Oral_rat to Inhalation_human factor do not apply (Table R. 8-4 p.26) with the prefered approach (step 1.route-to-route extrapolation within one species, step 2. interspecies extrapolation within the same exposure route), which was used here (see right-hand side of the example R. 8-2 p. 59). The alternative approach is reverse (step 2. before step 1.) and allometric scaling would apply in this case (see left-hand side of the example R. 8-2 p. 59)
- AF for other interspecies differences:
- 2.5
- Justification:
- The default value of 2.5 is used to correct for other interspecies differences because EAK is taken up via the mucuous membrane of the respiratory tract in the system (R8, p.24: If no substance-specific data are available, the standard procedure for threshold effects would be, as a default, to correct for differences in metabolic rate (allometric scaling) and to apply an additional factor of 2.5 for other interspecies differences, i.e. toxicokinetic differences not related to metabolic rate (small part) and toxicodynamic differences (larger part)
- AF for intraspecies differences:
- 5
- Justification:
- For workers, as standard procedure for threshold effects, a default assessment factor of 5 is to be used (R8 p.28)
- AF for the quality of the whole database:
- 1
- Justification:
- Assumption: good/standard quality of database, i.e. standard data requirements are fulfilled (R8, p. 31)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
- DNEL extrapolated from long term DNEL
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 53 mg/m³
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 1
- Dose descriptor starting point:
- other: IOEL
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- Default factor according to R8, p. 19; On the assumption that, in general, dermal absorption will not be higher than oral absorption, no default factor (i. e. factor 1) should be introduced when performing oral-to-dermal extrapolation.
- AF for dose response relationship:
- 1
- Justification:
- When the starting point for the DNEL calculation is a NOAEL, the default assessment factor, as a standard procedure, is 1. (R8, p.30). A factor of 1 was chosen eventhough only 5 rats were used as the study complies to all other requirements from OECD
- AF for differences in duration of exposure:
- 2
- Justification:
- Chronic to sub-chronic (Table R. 8-5 p.29)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Allometric factor may be used according to Table R. 8.4 (Oral_rat to Dermal_human). Allometric factor taken from Table R. 8.3
- AF for other interspecies differences:
- 2.5
- Justification:
- The default value of 2.5 is used to correct for other interspecies differences because EAK is taken up via the skin in the system (R8, p.24: If no substance-specific data are available, the standard procedure for threshold effects would be, as a default, to correct for differences in metabolic rate (allometric scaling) and to apply an additional factor of 2.5 for other interspecies differences, i.e. toxicokinetic differences not related to metabolic rate (small part) and toxicodynamic differences (larger part)
- AF for intraspecies differences:
- 5
- Justification:
- For workers, as standard procedure for threshold effects, a default assessment factor of 5 is to be used (R8 p.28)
- AF for the quality of the whole database:
- 1
- Justification:
- Assumption: good/standard quality of database, i.e. standard data requirements are fulfilled (R8, p. 31)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
Acute systemic hazards via inhalation were not evaluated since acute local data (IOEL) available is more relevant than a derivation of the DNEL for acute systemic effect from a LC50.
As 5-methylheptan-3-one is not classified for acute toxicity via skin, short-term systemic exposure does not have to be evaluated according to the REACH "Guidance on information requirements and chemical safety assessment Chapter R.8: Characterization of dose [concentration]-response for human health".
As no information on dose-response for eye (local effect) and skin is available, no DNEL was derived for these endpoints. However, a qualitative approach to assessing and controlling the risks was followed (Guidance on information requirements and chemical safety assessment Part E: Risk Characterization). As 5-methyheptan-3-one was simultaneously classified with the H-phrases H319 (causes serious eye irritation, R36 according to Directive 67/548/EEC), H315 (causes skin irritation, R38 according to Directive 67/548/EEC) and H335 (STOT SE 3, R37 according to Directive 67/548/EEC) according to Regulation (EC) 1272/2008, it was allocated to the medium hazard category.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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