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Diss Factsheets
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EC number: 205-094-9 | CAS number: 133-14-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No guideline followed. Not a GLP study. Evaluation of clinical symptoms was not reported. The identity of the test material was not established.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Graded doses of the test material were applied to the skin of rabbits and observed for 14 days.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Bis(2,4-dichlorobenzoyl) peroxide
- EC Number:
- 205-094-9
- EC Name:
- Bis(2,4-dichlorobenzoyl) peroxide
- Cas Number:
- 133-14-2
- Molecular formula:
- C14H6Cl4O4
- IUPAC Name:
- 2,4-dichlorobenzoyl 2,4-dichlorobenzene-1-carboperoxoate
- Test material form:
- not specified
- Details on test material:
- Details were not provided clearly and completely except a handwritten note "50% in silicone oil" on page 1 of the entire report summarizing the conclusions from 3 different toxicity studies. In the dermal toxicity study report, the test material is stated as Cedox TS-50.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Eight rabbits equally divided as to sex, weighing 2317 to 2831 gms were used. No other details were provided.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- The hair was clipped from the back of each rabbit. the skin was abraded for 1/2 of the rabbits in each group. The rabbits were divided into four groups of 2 rabbits (one male and one female) for each group (dose levels of 1000, 2000, 3000, and 4000 mg/kg). The test material was applied as received to the backs in appropriate doses. The site of application was covered with gauze bandaging and occluded with Saran wrap.
- Duration of exposure:
- 14 days
- Doses:
- 1000, 2000, 4000 and 8000 mg/kg
- No. of animals per sex per dose:
- one male and female per dose.
- Control animals:
- no
- Details on study design:
- No other details provided
- Statistics:
- None
Results and discussion
- Preliminary study:
- The rabbits were observed for death at 24 hours and daily thereafter for a total of 14 days. It was concluded that the acute dermal toxicity (LD50) value in albino rabbits would be greater than 8000 mg/kg.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 8 000 mg/kg bw
- Based on:
- other:
- Remarks on result:
- other: Not clear as to how the dose formulations were calculated and prepared from the test item.
- Mortality:
- None.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal toxicity (LD50) value in albino rabbits would be greater than 8000 mg/kg.
- Executive summary:
There were no mortalities.
Although the study concluded that the LD50 value in rabbits was greater than 8000 mg/kg, due to the non-GLP nature of the experiment, and the lack of some details on the test item and some experimental conditions, the level of confidence in the conclusions is somewhat less reliable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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