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EC number: 214-317-9 | CAS number: 1120-71-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
A high potential for genetic toxicity of the test item was indicated in in vitro test systems (e.g. Ames test, chromosomal aberration test, micronucleus test).
Link to relevant study records
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 473 (In Vitro Mammalian Chromosome Aberration Test)
- Deviations:
- not applicable
- GLP compliance:
- no
- Type of assay:
- other: in vitro mammalian chromosome aberration test
- Target gene:
- not applicable
- Species / strain / cell type:
- mammalian cell line, other: Chinese hamster lung fibroblast cell line (CHL)
- Details on mammalian cell type (if applicable):
- - originally established from the lung of a young adult by Dr. T. Utakoji, Cancer Institute, Tokyo
- karyotype consists of 25 chromosomes
- maintained by 5-day passages
- grown in a monolayer in petri dishes with Eagle's MEM (GIBCO F-11) supplemented with 10 % calf serum
- doubling time was estimated as 18.2 h at their exponential growth at 37 °C in a 5 % CO2 atmosphere - Metabolic activation:
- without
- Test concentrations with justification for top dose:
- 0.0313 , 0.0625 or 0.125 mg/mL
- Vehicle / solvent:
- - physiological saline
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- Remarks:
- solvent: physiological saline
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- not specified
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in medium
DURATION
- Exposure duration: 24 and 48 h
- Fixation time (start of exposure up harvest of cells): 24 and 48 h
SPINDLE INHIBITOR (cytogenetic assays): colcemid (0.2 µg/mL; added to the medium 2 h before harvest)
STAIN (for cytogenetic assays): 1% Giemsa's buffered solution (pH 6.8)
NUMBER OF REPLICATIONS: no data
NUMBER OF CELLS EVALUATED: the number of cells with chromosomal aberrations was recorded on 100 well-spread metaphases
DETERMINATION OF CYTOTOXICITY
- only examinded in a pre-test (growth inhibition test)
- the dose inducing a 50% growth inhibition was taken as the highest dose in the main test
Growth inhibition tests carried out before the chromosome tests were started:
The 50% growth inhibition dose was estimated as follows:
Several different doses of each agent were separately added to the 3-day-old cultures (about 6 x 10E3 cells/3-cm dishes). The doses were prepared by a factor of 2 from the maximal dose, estimated from the data on LD50, which appeared in references for the test item. The cells in a monolayer were washed, fixed with 10% formalin solution, and then stained with 0.1% crystal violet solution for 3 min. After washing and drying each dish was placed under a photodensitometer to measure the color absorption values from which relative cell densities on the dishes were easily calculated. The color absorption values obtained reflected well the actual number of cells that survived at the bottom of each petri dish.
OTHER EXAMINATIONS:
- Determination of polyploidy: yes
OTHER:
- types of aberration were classified into 5 groups: chromatid gaps, chromatid breaks, chrorrmatid or chromosomal translocation, ring formation and fragmentation or pulverization - Evaluation criteria:
- CHL cells commonly have less than 3.0% cells with chromosomal aberrations. Therefore, the final judgement given to all experimental groups was as follows: Negative if less than 4.9% of the aberration was detected – even when doses of the agent were elevated to sub-lethal amounts, where almost no mitosis was observed; suspicious if between 5.0 and 9.9%, and positive if between 10.0 and 19.9% (+), 20.0 and 49.9% (++) and more than 50.0% (+++). When no reasonable dose response was obtained, experiments with different doses were carried out to confirm its reproducibility.
- Statistics:
- no data
- Key result
- Species / strain:
- mammalian cell line, other: Chinese hamster fibroblast cell line (CHL)
- Metabolic activation:
- without
- Genotoxicity:
- positive
- Remarks:
- 94% cells with abberations
- Cytotoxicity / choice of top concentrations:
- other: cytotoxicity can be assumed as the dose where 50% growth inhibition occured in the pre-test was used as the highest dose
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- not examined
- Additional information on results:
- TEST-SPECIFIC CONFOUNDING FACTORS
- no data
COMPARISON WITH HISTORICAL CONTROL DATA:
- CHL cells commonly have less than 3.0% cells with chromosomal aberrations. This value was taken for judgement. - Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- not applicable
- Principles of method if other than guideline:
- - test was conducted only in absence of S9 mix at one test concentration
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
- Target gene:
- not applicable
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- S. typhimurium TA 1538
- Species / strain / cell type:
- other: S. typhimurium TA 1536
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- 5 µg per plate
- Vehicle / solvent:
- no data
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- 4-nitroquinoline-N-oxide
- Remarks:
- 1 µg
- Details on test system and experimental conditions:
- METHOD OF APPLICATION:
- in agar (plate incorporation)
NUMBER OF REPLICATIONS:
- no data
DETERMINATION OF CYTOTOXICITY
- Method: colonies were counted - Evaluation criteria:
- Mutagens were defined as chemicals that induced a reproducible dose-related increase in the number of histidine-independent revertants.
- Statistics:
- not applicable
- Species / strain:
- S. typhimurium, other: TA 1535, TA 100
- Metabolic activation:
- without
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Species / strain:
- S. typhimurium, other: TA 1536, TA 1537, TA 98 and TA 1538
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Additional information on results:
- Revertants/ plate after subtacting background:
TA 1535: 170 (vehicle control: 25 - 55)
TA 100: 290 (vehicle control: 100 - 180) - Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- not applicable
- Principles of method if other than guideline:
- - the test item was only tested in the absence of S9 mix at unspecified concentrations
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
- Target gene:
- not applicable
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102
- Species / strain / cell type:
- S. typhimurium TA 97
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- no data
- Vehicle / solvent:
- no data
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- yes
- Remarks:
- not specified
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: methylnitronitrosoguanidine
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation)
- Species / strain:
- S. typhimurium, other: TA 1535, 1537, 98, 100 and 102
- Metabolic activation:
- without
- Genotoxicity:
- positive
- Remarks:
- the frequency of induced mutants was more than 2-5 fold the spontaneous background
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Species / strain:
- S. typhimurium TA 97
- Metabolic activation:
- without
- Genotoxicity:
- positive
- Remarks:
- the frequency of induced mutants was more than 2-5 fold the spontaneous background
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Additional information on results:
- The frequency of induced mutants was more than 2-5 fold the spontaneous background.
- Endpoint:
- genetic toxicity in vitro, other
- Remarks:
- Summary of various types of genotoxicity tests
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only result is given without any further detail
- GLP compliance:
- no
Referenceopen allclose all
A D20 value (the dose (mg/mL) at which chromosomal aberrations were detected in 20% of metaphases) of 0.0451 mg/mL was obtained.
Results chromosome test (only 24 values are presented):
Dose [mg/mL] |
No of Metaphases |
Polyploid cells [%] |
Cells with structural chromosome aberrations [%], 24 h |
|||||||
|
|
24 h |
48 h |
G |
B |
T |
R |
F |
Total |
|
|
|
|
|
|
|
|
|
|
|
|
None |
100 |
1 |
- |
1 |
0 |
0 |
0 |
0 |
1 |
|
Solv |
|
- |
- |
- |
- |
- |
- |
- |
- |
|
0.0313 |
100 |
0 |
1 |
1 |
3 |
2 |
0 |
0 |
6 |
|
0.0625 |
100 |
1 |
0 |
2 |
7 |
16 |
0 |
0 |
22 |
|
0.125 |
100 |
1 |
T |
0 |
46 |
91 |
0 |
0 |
94 |
G: chromatid gaps
B: chromatid or chromosomal breaks
T: translocation
R: ringformation
F: fragmentation
Summary: Genotoxicity studies and related tests with 1,3-propane sultone
Test system |
Dose or concentration |
Test result |
Observations |
Ref. |
in vivo/in vitro transformation assay (hamster embryo cells exposed transplacentally) |
1.0 - 3.0 mg/ 100 g i.p. |
+ |
neoplastic transformation in cultured cells obtained from embryos after transplacental exposure |
DiPaolo et al., 1973 |
inhibition of in vivo3H-thymidine incorporation in kidneys of suckling mice |
0.1 mL/mouse (c 15-30% of LD50), i.g. |
+ |
marked inhibition of DNA synthesis in kidney cells |
Amlacher et al., 1983 |
cell transformation test in hamster embryo fibroblasts |
0.1, 1.0, 10 mg/L |
+ |
cell transformation at 1 mg/l; results negative with lower and higher concentrations |
Pienta et al., 1977 |
cell transformation test in C3H/10T½CL8 cells |
25 - 100 µg/mL |
+ |
small number of transformed foci with highly toxic concentrations |
Oshiro et al., 1981 |
cell transformation test in C3H/10T½CL8 cells |
20 - 60 µg/mL |
+ |
marked dose-dependent transformation response |
Nesnow et al., 1982 |
reversion assay in S. typhimurium TA1535, TA1538 |
5 - 25 µg/plate |
+ |
dose-dependent increase in reversions in TA1535; effect effect reduced slightly by S9 mix; no effect in TA1538 |
Rosenkranz et al., 1971 |
6 tests in combination: |
various (appropriate for the test system) |
|
all tests yielded positive results apart from mouse skin sebaceous gland suppression test |
Purchase et al., 1978 |
Ames test in S. typhimurium (4 strains); mammalian cell transformation test (BHK21/cl13 Syrian hamster kidney cells) |
|
+ + |
|
|
degranulation of rat liver rough endoplasmic reticulum; |
|
+ |
|
|
tetrazolium reduction test; |
|
+
|
|
|
mouse skin sebaceous gland suppression test; subcutaneous implantation test |
|
- + |
|
|
reversion test in Escherichia coli 343 |
1 mg/mL |
+ |
reversion of mutants unable to utilize galactose |
Mohn, 1971 |
reversion test in E. colli WP2 |
n.s. |
+ |
reversion of tryptophan-auxotrophic mutants |
Dean, 1972 |
assay of differential growth of repair-defective mutants and wild type Proteus mirabilis |
610 µg/plate |
+ |
slightly more inhibition of growth of repair-defective mutants than of wild type |
Adler et al., 1976 |
reversion test in Serratia marcescens α13 and α21 |
25 mg/mL (in DMSO) |
+++ |
reversion of histidine (α13) and leucine (α21) auxotrophic mutants |
Dean, 1972 |
forward and back mutation assays in bacteriophage T4 |
1.6 mg/mL |
+ |
various types of point mutation, mostly base pair transitions; very potent mutagen |
Corbet et al., 1970 |
mitotic recombination assay in Saccharomyces cerevisiae D3 |
0.1% (w/v) |
+ |
increased recombination frequency |
Simmon, 1979 |
reversion test Schizosaccharomyces pombe |
2 - 15 mM |
+ |
dose-dependent increase in reversions in auxotrophic mutants |
Heslot, 1962 |
References:
DiPaolo, J.A., R.L. Nelson,P.J. Donovan, Ch. H. Evans: Arch. Path. 95, 380 (1973)
Amlacher, E., Ch Rudolph: Arch. Geschwulstforsch. 51, 603 (1981)
Pienta, R.J., J.A. Poiley, W.B. Lebherz: Int. J. Cancer 19, 642 (1977)
Oshiro, Y., P.Sl Balwierz, S. V. Molinary: Toxicol. Lett. 9, 301 (1981)
Nesnow, S., H. Garland, G. Curtis: Carcinogenesis 3, 377 (1982)
Rosenkranz, R.S., L.A. Poirier: J. nat. Cancer Inst. 62, 873 (1971)
Purchase, I. F. H., E. Longstaff, J., J.Ashby, J.A. Styles, D. Anderson, P.A. Lefevre, F.R. Westwood: Brit. J. Cancer 37, 873 (1978)
Mohn, G.: Arch. Toxikol. 28, 93 (1971)
Adler, B., R. Brauch, J. Schöneich, H. Böhme: Biol. Zbl. 95, 463 (1976)
Corbett, Zh H., C. Heidelberger, F. D. Dove: Molec. Pharmacol. 6, 667 (1970)
Simmon, V. F.: J. nat.. cander Inst. 62, 893 (1979)
Heslot, H.: Abhandl. deut. Akad. Wiss. Berlin Kl. Med., 193, (1962)
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (positive)
Genetic toxicity in vivo
Description of key information
A high potential for genetic toxicity of the test item was indicated in in vivo test systems (e.g. Micronucleus test, DNA damage).
Link to relevant study records
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Deviations:
- not applicable
- GLP compliance:
- not specified
- Type of assay:
- other: micronucleus assay
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Diet (ad libitum): commercial pellets
- Water (ad libitum): yes
ENVIRONMENTAL CONDITIONS
- no data - Route of administration:
- intraperitoneal
- Vehicle:
- - saline
- Duration of treatment / exposure:
- - animals were treated with the test substance twice (24 h intervall) and peripheral blood was collected up to 72 h after last treatment
- Frequency of treatment:
- - twice (24 h intervall)
- Post exposure period:
- - 24, 48, 72 h
- No. of animals per sex per dose:
- - 5 male mice per dose
- Control animals:
- yes
- Positive control(s):
- - Mitomycin C
- Route of administration: ip
- Doses / concentrations: 0.5 mg/kg (single dose) - Tissues and cell types examined:
- - peripheral blood reticulocytes were used for analyses
- Details of tissue and slide preparation:
- CRITERIA FOR DOSE SELECTION:
- The highest dose was fixed by the preliminary dose-finding test (based on mortality)
METHOD OF ANALYSIS:
- Micronucleated reticulocyte frequencies were based on the observation of at least 1000 polychromatic reticulocytes - Statistics:
- When the control data were acceptable, the increase in micronucleus frequency against the concurrent negative control data were evaluated using a conditional binomial test and the dose response relationship using the Cochran-Armitage trend test were evaluated. When these were both significant, the data was declared positive. If neither step showed significance, the data was judged negative. All other cases were called inconclusive.
- Key result
- Sex:
- male
- Genotoxicity:
- positive
- Toxicity:
- yes
- Remarks:
- can be assumed, since the highest dose tested was fixed by a preliminary dose-finding test
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Endpoint:
- genetic toxicity in vivo, other
- Remarks:
- Summary of various types of genotoxicity tests
- Type of information:
- other: Review
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary source.
Referenceopen allclose all
Summary of the micronucleus assay results:
% micronucleated reticulocytes |
|||||||
|
|||||||
dose |
0 h |
24 h |
48 h |
72 h |
|||
mg/kg bw |
mean SD |
mean SD |
p |
mean SD |
p |
mean SD |
p |
|
|
|
|
|
|
|
|
9 |
0.08± 0.04
|
0.17± 0.10
|
0.151
|
0.10± 0.13
|
0.500
|
0.08± 0.10
|
0.623
|
18 |
0.10± 0.11
|
0.23± 0.10
|
0.058 |
0.10± 0.11
|
0.613 |
0.07± 0.05
|
0.828 |
36 |
0.12± 0.08
|
0.87± 0.53
|
< 0.001 |
0.63± 0.16
|
< 0.001 |
0.28± 0.16
|
0.032 |
72 |
0.10± 0.09
|
1.92± 0.99
|
< 0.001 |
1.68± 0.50
|
< 0.001 |
0.27± 0.14
|
0.026 |
p: value of the pairwise comparison
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (positive)
Mode of Action Analysis / Human Relevance Framework
Additional information
Ames-test:
In a reverse gene mutation assay the bacteria strains TA 1535, TA 1536, TA 1537, TA 1538, TA 98 and TA 100 of S. typhimurium were exposed to 1,3-propanesultone at a concentration of 5 µg/plate in the absence of mammalian metabolic activation applying the standard plate incorporation method (Simmon, 1979). The test item was found to be mutagenic in tester strains TA 1535 and TA 100 (170 and 290 revertants per plate after subtracting the background, respectively).
In another reverse gene mutation assay the bacteria strains TA 1535, TA 97, TA 1537, TA 102, TA 98 and TA 100 of S. typhimurium were exposed to 1,3-propanesultone in the absence of mammalian metabolic activation applying the standard plate incorporation method (Khudoley, 1987). The test item was found to be mutagenic in all tester strains (the frequency of induced mutants was more than 2 - 5 fold the spontaneous background).
Chromosomal aberration in vitro:
An in vitro assay for chromosomal damage was conducted in CHL cells to identify the potential 1,3-propanesultone to induce chromosomal aberrations (Ishidate, 1977). CHL cells were exposed to the test item at concentrations of 0, 0.0313, 0.0625 or 0.125 mg/mL without metabolic activation. A positive result for the test item was obtained as in 94 % of the cells analysed chromosomal aberrations were detected.
Micronucleus test in vitro and in vivo:
The potential of 1,3-propanesultone to induce micronuclei in vitro was examined in primary cultured astrozytes derived from 4 - 5 day old rats in the absence of metabolic activation (Ooida et al., 2000). After an exposure time of 24 hours the cells were fixed, stained and examined for mironuclei (MN). The frequencies of MN cells obtained in the dose-response study increased significantly at 0.08 (p < 0.05), 0.16 (p < 0.01) and 0.31 mM (p < 0.01). A dose-response relationship of the frequency of MN cells was observed up to 0.31 mM 1,3-propanesultone. Frequencies of MN cells decreased at 0.63 mM because of toxicity. The 50% growth inhibition ratio of 1,3-propanesultone was observed at 0.56 mM.
An in vivo micronucleus assay in mice was performed with 1,3-propanesultone given twice intraperitoneally (24-hour interval) at doses of 0, 9, 18, 36 or 72 mg/kg bw (Morita et al., 1997). 24, 48 and 72 hours after last application peripheral blood reticulocytes were sampled and analysed for micronulei. 1,3-propanesultone induced statistically significant increases (p<0.05) of micronucleated cells at all dose time points at doses of 36 and 72 mg/kg bw.
Other tests on genotoxicity:
Numerous other tests on genetic toxicity in vitro and in vivo (MAK, 1985; Raschig, 2009) indicate also a high mutagenic potential of 1,3-propanesultone.
Justification for classification or non-classification
The available data show that 1,3-propanesultone is mutagenic in various in vitro and in vivo test systems. Thus, 1,3-propanesultone is subject for classification and labelling according to Regulation 1272/2008/EC (Cat. 2, H341) regarding mutagenicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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