Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-442-4 | CAS number: 106-92-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Allyl glycidyl ether (AGE) is irritating to skin and respiratory system and causes irreversible effects on the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation:
In the key study (Hine et al. 1956), rabbits (n = 3) were exposed to undiluted AGE under a occlusive dressing during 24 hours and observed for 72 hours. Slight to well defined erythema and oedema were observed on intact skin at 24 and 72 hours after patch removal. One animal showed a severe oedema at 24 hours. No readings were done at 1 and 48 hours and no information on possible reversibility of the effects were given. These results were supported by another study (BASFAG VIII/219, 1968), where 2 rabbits were exposed to undiluted AGE (ca. 65% pure) for 1, 5, 15 min and 20 h under occlusive conditions. Slight erythema (score 1) was observed only in 1 animals after 24 h after 1, 5 or 15 min exposure, which was reversible within 48 h. After 20 h exposure, necrosis was observed along with erythema and edema was observed after 72 h in one animal. Moderate erythema and edema was observed in the second animal, which was not reversible within 8 days of observation period.
Taking all the presented data into consideration, AGE is classified as “irritant”, R38 according to EU standards and in Cat 2 according to GHS // CLP standards.
Eye irritation:
In an eye irritation study (Hine et al. 1956), performed with 3 rabbits where 0.1 ml undiluted AGE was instilled in one eye of each rabbit, the other eye being the control.were done after 1, 24 and 48 hours. However, individual scores for effects on cornea, iris and conjunctivae were not reported but overall scores given. Based on these scores AGE was considered to be severely irritating to the eyes. No information on possible reversibility of the effects was given. In another study (BASFAG VIII/219, 1968), no irritating effects were observed, where 50 µl of AGE was applied to the conjunctival sac of one eye of 2 rabbits. Based on the overall results, AGE is classified as R41 according to EU standards and in Cat 1 according to GHS / CLP standards.
Respiratory irritation:
No standard test method exists for the assessment of respiratory irritation. There is evidence that AGE causes respiratory irritation following repeated inhalation exposure. Additionally, in an inhalation test (Gagnaire et al. 1987), the upper respiratory tract effects resulting from a short-term exposure to AGE vapors in mice was conducted through oro-nosal route at concentrations of 8.9, 15.9, 19.6, 23.6, 29.6, 40.1 mg/m3 for 15 min. The parameter chosen as an index of sensory irritation was the reflex decreases in respiratory rate (50% decreases in the respiratory rate, RD50). There was dose related decrease in the respiratory rate observed and RD50 was established to be 26.6 mg/m3.
In the same study (Gagnaire et al. 1987), pulmonary toxicity effects resulting from a short-term exposure to AGE via tracheal cannulation were conducted in mice. A polyethylene cannula was inserted in the trachea and secured in anaesthetized mice and were exposed at concentrations of 490, 555.3, 760.6 and 863.3 mg/m3 AGE vapors for 120 min. Animals were allowed to recover from anesthesia for 75 min before the measurements of the respiratory rate (50% decreases in the respiratory rate, RD50). No recovery was observed after the end of exposure when tracheally cannulated mice were allowed to breathe fresh air. The 4 exposure concentrations produced an effect which developed slowly, the peak of the response occurring after 120 min of exposure; at this time of exposure the RD50 value was calculated to be 625.3 mg/m3.
AGE is already labeled as "R 37, Irritating to respiratory tract" according to current EU regulations based on the above results and general irritation potential of AGE.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: highly irritating
Effects on respiratory irritation: irritating
Justification for classification or non-classification
EU classification according to Annex I of Directive 67/548/EEC: Xi, R37/38, R41
CLP Regulation (EC No 1272/2008):
- Skin corrosion/irritation: Category 2
- Serious eye damage/eye irritation: Category 1
- Specific target organ toxicity, Single exposure: Category 3 (May cause respiratory irritation)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)