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Diss Factsheets
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EC number: 203-603-9 | CAS number: 108-65-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-methoxy-1-methylethyl acetate
- EC Number:
- 203-603-9
- EC Name:
- 2-methoxy-1-methylethyl acetate
- Cas Number:
- 108-65-6
- Molecular formula:
- C6H12O3
- IUPAC Name:
- 2-methoxy-1-methylethyl acetate
- Details on test material:
- - Name of test material (as cited in study report): Dowanol PM Acetate (Propylene Glycol Methyl Ether Acetate or 1-methoxy-2-propanol acetate)
- Physical state: Clear liquid
- Analytical purity:
- Impurities (identity and concentrations):
- Composition of test material, percentage of components:
Propylene Glycol Methyl Ether Acetate
Secondary Isomer - 95.21%
Primary Isomer - 4.59%
Propylene Glycom Methyl Ether
Secondary Isomer - 0.17%
Primary Isomer - 0.07%
Water - 0.046%
Acetic acid - 0.0156%
- Lot/batch No.: DPC 203-92 #3
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMAL
Animal care facility was accredited by the American Association for Accreditation of Laboratory Animal Care
- Source: Langshaw Farms, Augusta, Michigan
- Age at study initiation: not specified
- Housing: Rabbits were housed singly
- Diet (e.g. ad libitum): Commercial laboratory chow (Ralston Purina Company, St. Louis, Missouri) ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12-hour light and dark cycle
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Twenty-four hours prior to application of the test material, the entire trunk of 2 male and 2 female rabbits was clipped free of hair with electric clippers. The undiluted test material was applied under a heavy-gauge SARAN film sleeve which was held in place with rubber bands. The plastic sleeve was covered by cloth bandage taped securely to the marginal hair. After 24 hours, the sleeves were removed, and the skins were washed with a mild soap and water, rinsed thoroughly and dried with a soft disposable towel. The rabbits were immediately fitted with a plastic collar to prevent them from ingesting any residue of the material which may still be present after washing. The collars were removed at least 72 hours later. The topical response at the site of application was evaluated after removal of the plastic sleeve.
- Duration of exposure:
- 24 hours
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 2 males and 2 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were observed frequently during exposure and the following two weeks for signs of toxicity. Body weights were recorded before and after the 24 hour exposure period and at 1 and 2 weeks post treatment
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortality
- Clinical signs:
- other: Topical responses observed when the sleeves of test rabbits were removed included very slight (3/4) erythema and slight (1/3) edema. All rabbits were lethargic following dosage
- Gross pathology:
- No treatment related lesions were observed upon gross pathological examination of all rabbits at 2 weeks following treatment.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- As the LD50 value was greater than 5000 mg/kg, the test material is not classified according to EU criteria.
- Executive summary:
A sample of Dowanol* PM Acetate also known as Propylene Glycol Methyl Ether Acetate and identified as DPC 203-92 # 3 was submitted for acute percutaneous absorption testing. Male and femalealbino rabbits were used in the study.
Twenty-four hours prior to application of the test material, the entire trunk of 2 male and 2 female rabbits/dose level (5000 mg/kg) was clipped free of hair with electric clippers. The undiluted test material was applied under a heavy-gauge SARAN film sleeve which was held in place with rubber bands. The plastic sleeve was covered by cloth bandage taped securely to the marginal hair. After 24 hours, the sleeves were removed, and the skins were washed with a mild soap and water, rinsed thoroughly and dried with a soft disposable towel. The rabbits were immediately fitted with a plastic collar to prevent them from ingesting any residue of the material which may still be present after washing. The collars were removed at least 72 hours later. The topical response at the site of application was evaluated after removal of the plastic sleeve.
The animals were observed frequently during exposure and the following 2 weeks for signs of toxicity. Body weights were recorded before and after the 24 hour exposure period and at 1 and 2 weeks post treatment. All rabbits were submitted for a gross pathological examination 2 weeks post treatment.
The acute percutaneous absorption LD50 was >5000 mg/kg. Topical responses observed when the sleeves of test rabbits were removed included very slight (3/4) erythema, slight (1/3) edema. All rabbits were lethargic following dosage. No treatment-related lesions were observed upon gross pathological examination of all rabbits at 2 weeks following treatment. As a result test material is not classified according to EU criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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