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Diss Factsheets
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EC number: 200-871-9 | CAS number: 75-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- one-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study details not reported
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
- Principles of method if other than guideline:
- not reported
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Chlorodifluoromethane
- EC Number:
- 200-871-9
- EC Name:
- Chlorodifluoromethane
- Cas Number:
- 75-45-6
- Molecular formula:
- CHClF2
- IUPAC Name:
- chlorodifluoromethane
- Details on test material:
- not reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Charles River Rats
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- not reported
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- air
- Details on exposure:
- not reported
- Details on mating procedure:
- not reported
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- not reported
- Duration of treatment / exposure:
- days 6-15 of gestation
- Frequency of treatment:
- daily
- Details on study schedule:
- not available
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 0.05, 0.10, 2.00%
Basis:
nominal conc.
- No. of animals per sex per dose:
- 40
- Details on study design:
- not available
- Positive control:
- not reported
Examinations
- Parental animals: Observations and examinations:
- not reported
- Oestrous cyclicity (parental animals):
- not reported
- Sperm parameters (parental animals):
- not reported
- Litter observations:
- not reported
- Postmortem examinations (parental animals):
- not reported
- Postmortem examinations (offspring):
- not reported
- Statistics:
- not reported
- Reproductive indices:
- not reported
- Offspring viability indices:
- not reported
Results and discussion
Results: P0 (first parental generation)
General toxicity (P0)
- Clinical signs:
- no effects observed
Details on results (P0)
resorptions, and number of live fetuses per litter were unaffected.
Results: F1 generation
General toxicity (F1)
- Clinical signs:
- no effects observed
- Histopathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- poradic appearance of major malformations of the eye
Details on results (F1)
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
not available
Applicant's summary and conclusion
- Conclusions:
- No clinical signs of toxicity were observed in maternal animals. The number of implantations, early and late resorptions, and number of live fetuses per litter were unaffected. There was a sporadic appearance of major malformations of the eye in all test groups. The increased incidence of eye defects was not statistically significant. Authors believe that the test substance may have interacted with the genetic make-up of affected fetuses and caused the increased expressivity of a mutant gene. The authors considered the test substance to be a mutagen under the conditions of this study.
- Executive summary:
- In a one generation study 40 female Charles river rats were exposed to nominal concentrations of 0, 0.05, 0.10, 2.00%. No clinical signs of toxicity were observed in maternal animals. The number of implantations, early and late resorptions, and number of live fetuses per litter were unaffected. There was a sporadic appearance of major malformations of the eye in all test groups. The increased incidence of eye defects was not statistically significant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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