Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 906-151-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (4 d) = 0.3 mg/L on Gadus morrhua (marine, no guideline, embryo and sac-fry stage)
NOEC (32 d) = 1.35 mg/L on Pimephales promelas (freshwater, OECD 210)
Key value for chemical safety assessment
Additional information
freshwater study
Long-term effects of p-cresol to the freshwater species Pimephales promelas were tested in a study similar to OECD 210 (Barron and Adelman, 1984). After an exposure period of 32 d a NOEC of 1.35 mg/L was found. This value is included in the PNEC derivation for freshwater.
marine study
Long-term effects of o-, m-, and p-cresol to different life stages were measured in a non-guideline study using fertilized fish eggs and larvae of the marine fish species Gadus morrhua (Atlantic cod) (Falk-Petersen et al. 1985). Eggs and larvae were incubated for 4 d (eggs) to 6 d (larvae) and monitored for sublethal effects during the post-exposure periods of up to 12 d. The 4-d EC50 was >30 mg/L (highest test concentration) for o-, and m-cresol. From lowest non-lethal effects at 10 mg/L, a NOEC of 3 mg/L was derived for o-, and m-cresol. The most critical NOEC of 0.3 mg/L was found for p-cresol. This study is comparable to a short-term toxicity test on embryo and sac-fry stages (EU Annex V C.15, OECD 212), which would be a suitable replacement of a true chronic test (EU TGD 2003). It has some shortcomings regarding documentation and the exposure time is limited to parts of the observation period. However, as the experimental results of 3 different exposure periods support each other, the test can be used as "reliable with restrictions".
Comparing results on freshwater and marine fish species the most sensitive NOEC of 0.3 mg/L was found for the marine compartment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)