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Diss Factsheets
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EC number: 202-319-2 | CAS number: 94-28-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Both for the skin and eye irritation, key studies were available according to internationally accepted testing and GLP guidelines, demonstrating that the test material is slightly irritating to skin and eye. Supporting studies were available for triethyleneglycol-bis(2-ethylhexanoic acid) ester, indicating that the substance is a mild skin irritant, but not an eye irritant. Responses were not severe enough to warrant any classification.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Two in vivo studies reported on skin irritation.
A key study was performed with single application of 0.5 mL of the test material (99.1% purity) to the skin of three rabbits for 4 hours (Sanders, 2007c). This study was conducted according to internationally accepted testing and GLP guidelines, and was considered to be reliable, adequate and relevant. Very slight erythema was noted at all treated skin sites at the 24 and 48-hour observations and at one treated skin site at the 72-hour observation.The test material produced a primary irritation index of 0.7/4 and was classified as mild irritant to rabbit skin according to Draize classification scheme. No corrosive effects were noted.
A supporting, acute dermal irritation/corrosion test was carried out according to OECD 404, with administration of 0,5 mL of triethyleneglycol-bis(2-ethylhexanoic acid) ester to the skin of three male rabbits for 4 hours (Mürmann, 1989a). Dermal irritation and corrosion were scored at 1, 24, 48 and 72 h and 6 days after removal of the test substance. In all animals, very light to clear erythema and swelling arose, that had completely disappeared after 6 days. The irritation index was 1.25/8 which led to the conclusion that a one time dermal application in male rabbits is slightly irritating.
Two in vivo studies reported on eye irritation.
A key study was performed with single application of 0.1 mL of the test material (99.1% purity) to the eye of three rabbits (Sanders, 2007d). This study was conducted according to internationally accepted testing and GLP guidelines, and was considered to be reliable, adequate and relevant. The test material produced minimal conjunctival irritation; two treated eyes appeared normal at the 24-hour observation and the remaining treated eye appeared normal at the 48-hour observation.The test material produced a maximum group mean score of 3,3 and was classified as a minimal eye irritant (Class 3 on a 1 to 8 scale) to the rabbit eye according to a modified Kay and Calandra classification system.
A supporting eye irritation/corrosion test (Mürmann, 1989b) was carried out according to OECD 405 with administration of 0,1 mL of triethyleneglycol-bis(2-ethylhexanoic acid) ester under the right eyelid of each of three male rabbits and evaluation at 1, 24, 48 and 72h and 6 days after application. The test chemical had no effect at all on cornea or iris, whereas conjunctiva redness was observed in all three animals 1 hour after application,however with complete recovery within 24 to 48h after application. With an irritation index of 0,67/110 this test material was considered not irritating.
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
Based on the skin/eye irritation scores determined in the discussed study reports, no classification is required.
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