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Diss Factsheets
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EC number: 304-661-9 | CAS number: 94277-77-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and OECD guideline compliant study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Hydrogen [tris[[[3-[(2-ethylhexyl)oxy]propyl]amino]sulphonyl]-29H,31H-phthalocyaninesulphonato(3-)-N29,N30,N31,N32]cuprate(1-), compound with 3-[(2-ethylhexyl)oxy]propylamine (1:1)
- EC Number:
- 304-661-9
- EC Name:
- Hydrogen [tris[[[3-[(2-ethylhexyl)oxy]propyl]amino]sulphonyl]-29H,31H-phthalocyaninesulphonato(3-)-N29,N30,N31,N32]cuprate(1-), compound with 3-[(2-ethylhexyl)oxy]propylamine (1:1)
- Cas Number:
- 94277-77-7
- Molecular formula:
- C65 H84 Cu N11 O12 S4 .C11 H25 N O .H
- IUPAC Name:
- copper(2+) hydrogen 3-[(2-ethylhexyl)oxy]propan-1-amine 14,24,32-tris({[({3-[(2-ethylhexyl)oxy]propyl}amino)oxy]sulfonyl})-2,11,20,29,37,38,39,40-octaazanonacyclo[28.6.1.1³,¹⁰.1¹²,¹⁹.1²¹,²⁸.0⁴,⁹.0¹³,¹⁸.0²²,²⁷.0³¹,³⁶]tetraconta-1,3(40),4,6,8,10,12,14,16,18,20,22,24,26,28(38),29,31,33,35-nonadecaene-37,39-diide-5-sulfonate
- Details on test material:
- - Substance type: blue solid
- Physical state: solid
- Purity: UBCB substance (100%)
- Purity test date: 2014
- Lot/batch No.: 070037P040
- Expiration date of the lot/batch: 01 January 2018
- Stability under test conditions: stable
- Storage condition of test material: at room temperature
- Other: The test substance appeared to be homogeneous.
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Charles River UK
- Age at study initiation: 8-9 weeks
- Weight at study initiation: 15.9 - 19.3 g
- Housing: all animals in one group were housed in a cage together as a group
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2°C
- Humidity (%): 45 – 65%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 2014-06-24 to 2014-07-29
Study design: in vivo (LLNA)
- Vehicle:
- dimethylformamide
- Concentration:
- 5, 10, 25 % (w/w).
- No. of animals per dose:
- 5
- Details on study design:
- RANGE FINDING TESTS:
- Compound solubility: max 25% in DMF (suspension)
- Irritation: none (blue staining)
- Lymph node proliferation response:
MAIN STUDY
ANIMAL ASSIGNMENT AND TREATMENT
- Name of test method: standard H-Methylthymidine incorporation
- Criteria used to consider a positive response: SI > 3
TREATMENT PREPARATION AND ADMINISTRATION: Each test group of mice was treated by topical (epidermal) application to the dorsal surface
of each ear with test item in dimethylformamide. The application volume, 25 μL/ear/day, was spread over the entire dorsal surface (diameter 8 mm) of each ear once daily for three consecutive days. A further group of mice (control animals) was treated with an equivalent volume of the relevant vehicle alone. - Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
In vivo (LLNA)
Results
- Parameter:
- SI
- Remarks on result:
- other: 1.95 (25%) - 1.74 (10%) - 1.8 (5%)
Any other information on results incl. tables
Lymph Node Cell Counts after Sacrifice | |||||
Test item concentration % (w/w) |
Animal No. |
Lymph Node Cell Count x10E06 per animal |
Mean Lymph Node Cell Count x10E06 per animal |
SD | Index (Value Test Group versus Value Control |
Vehicle Control (DMF) | 1 | 6.21 | 9.7 | 2.3 | 1.00 |
2 | 10.16 | ||||
3 | 11.23 | ||||
4 | 12.12 | ||||
5 | 8.70 | ||||
5 | 6 | 9.45 | 13.1 | 7.7 | 1.35 |
7 | 9.61 | ||||
8 | 26.84 | ||||
9 | 9.58 | ||||
10 | 9.92 | ||||
10 | 11 | 10.44 | 11.9 | 2.2 | 1.23 |
12 | 9.71 | ||||
13 | 15.17 | ||||
14 | 13.26 | ||||
15 | 11.02 | ||||
25 | 16 | 10.99 | 13.9 | 2.7 | 1.43 |
17 | 13.37 | ||||
18 | 17.81 | ||||
19 | 15.12 | ||||
20 | 12.14 |
Ear Weights after Sacrifice | |||||
Test item concentration % (w/w) |
Animal No. |
Ear weight mg per animal |
Mean Ear weight (mg) | SD | Index (Value Test Group versus Value Control) |
Vehicle Control (DMF) | 1 | 24.22 | 27.0 | 1.9 | 1.00 |
2 | 27.56 | ||||
3 | 27.88 | ||||
4 | 26.40 | ||||
5 | 29.15 | ||||
5.0% | 6 | 29.12 | 27.8 | 1.2 | 1.03 |
7 | 28.20 | ||||
8 | 26.06 | ||||
9 | 28.49 | ||||
10 | 27.05 | ||||
10% | 11 | 25.74 | 26.9 | 1.9 | 1.00 |
12 | 24.36 | ||||
13 | 29.02 | ||||
14 | 28.01 | ||||
15 | 27.41 | ||||
25% | 16 | 26.33 | 27.2 | 1.6 | 1.01 |
17 | 29.49 | ||||
18 | 28.08 | ||||
19 | 26.31 | ||||
20 | 25.71 |
Lymph Node Weights after Sacrifice | |||||
Test item concentration % (w/w) |
Animal No. |
Lymph Node weight mg per animal |
Mean Lymph Node weight (mg) | SD | Index (Value Test Group versus Value Control |
Vehicle Control (DMF) | 6 | 4.89 | 5.6 | 0.7 | 1.00 |
7 | 5.32 | ||||
8 | 6.29 | ||||
9 | 6.36 | ||||
10 | 5.14 | ||||
5 | 16 | 5.45 | 5.5 | 0.3 | 0.98 |
17 | 5.63 | ||||
18 | 5.03 | ||||
19 | 5.60 | ||||
20 | 5.78 | ||||
10 | 21 | 6.23 | 6.5 | 1.1 | 1.16 |
22 | 5.40 | ||||
23 | 8.16 | ||||
24 | 7.04 | ||||
25 | 5.58 | ||||
25 | 26 | 6.71 | 6.4 | 0.8 | 1.14 |
27 | 6.39 | ||||
28 | 7.27 | ||||
29 | 6.50 | ||||
30 | 5.13 |
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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