Registration Dossier
Registration Dossier
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EC number: 437-420-2 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No experimental data available.
Key value for chemical safety assessment
Additional information
No data are available on toxicokinetics, metabolism and distribution of the substance by the oral, dermal or inhalation routes.
The test material is a liquid that is not considered to be volatile because of the low vapour pressure value (<0.01 Pa (mean) 31 -36°C). The test material is expected to hydrolyse under physiological conditions.
Absorption: The results of the acute and repeat-dose oral toxicity studies in the rat show no evidence of significant systemic toxicity. It is likely that the test material is rapidly hydrolysed in the gastro-intestinal tract prior to absorption. This does not rule out absorption of the degradants.The physical characteristics of the parent material such as the lack of ionisable groups and moderately low molecular weight, would allow the material to be absorbed from the gastro-intestinal tract.
There is no evidence of systemic toxicity following acute dermal exposure to rats. This may be the result of the low inherent toxicity of the material or the test material is not absorbed.
Distribution:There is no evidence to indicate if the test material is distributed systemically.
Metabolism: The test material hydrolyses under physiological conditions, which suggests that it is susceptible to the action of non-specific hydrolase activity. There is no evidence to suggest that significant hepatic metabolism is involved. The result of an in vitro genotoxicity assay shows no enhanced or diminished activity in the presence of S9 metabolising system.
Excretion:There is
no evidence to indicate the route of excretion but it is most
likely that the kidney is the principal route for absorbed material. Any
unabsorbed test material will be excreted in the faeces.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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