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EC number: 242-359-8 | CAS number: 18479-51-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 May - 13 June 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted according to OECD Guideline 404 and under GLP conditions.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- Not relevant
- GLP compliance:
- yes
- Remarks:
- with statement of compliance
Test material
- Reference substance name:
- 3,7-dimethyloct-6-en-3-ol
- EC Number:
- 242-359-8
- EC Name:
- 3,7-dimethyloct-6-en-3-ol
- Cas Number:
- 18479-51-1
- Molecular formula:
- C10H20O
- IUPAC Name:
- 3,7-dimethyloct-6-en-3-ol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland, Kisslegg, Germany
- Age at study initiation: 7-9 weeks
- Weight at study initiation: 1.32 - 1.54 kg
- Housing: individually in cages with perforated floors
- Diet (e.g. ad libitum): 100 g/day, standard laboratory rabbit diet
- Water (e.g. ad libitum): ad libitum, tap water
- Acclimation period: at least 5 days under laboratory conditions
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21
- Humidity (%): 50
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: other flank of animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): undiluted (100%)
VEHICLE
- Not relevant - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48 and 72 hours and 7, 14 and 21 days after removal of test article
- Number of animals:
- 3 (starting with one sentinel rabbit)
- Details on study design:
- TEST SITE
- Area of exposure: flank, 10x15 cm2 clipped free and 2x3 cm patch applied
- % coverage: no data
- Type of wrap if used: metalline patch, wrapped around with Micropore tape and secured with Coban elastic bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): dressing removed and skin cleaned using water
- Time after start of exposure: 4 hours
SCORING SYSTEM:
Erythema and eschar:
0 - No erythema
1 - Very slight erythema (barely perceptible)
2 - Well-defined erythema
3 - Moderate to severe erythema
4 - Severe erythema (beet redness)
Oedema:
0 - No oedema
1 - Very slight oedema (barely perceptible)
2 - Slight oedema (edges of area well-defined by definite raising)
3 - Moderate oedema (raised approx. 1 mm)
4 - Severe oedema (raised more than 1 mm and extending beyond the area of exposure)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- animal no 27
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 3.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Remarks:
- animal no 31
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 3.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 21 days
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 21 days
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 21 days
- Irritant / corrosive response data:
- Severe erythema and moderate to severe edema was found in the treated skin-areas of the three rabbits.
Scaliness and a bald skin were seen in all animals after 7 and 14 days respectively.
No evidence of a corrosive effect on the skin was found. - Other effects:
- No symptoms of systemic toxicity were observed in the animals during the test period and no mortality occurred.
Any other information on results incl. tables
Results were evaluated according to the EC criteria for classification and labelling requirements for dangerous substances and preparations.
Sticky or dry remnants of the test substance were present on the skin up to 72 hrs. in one animal and up to 7 das in the other animals.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Severe erythema and moderate to severe edema was found in this study. Based on the mean erythema and/or edema formation scores of the three
rabbits, dihydrolinalool was found to be irritating to skin according to the criteria stated in Annex VII of the Dangerous Substance Directive (67/548/EEC). - Executive summary:
A primary skin irritaion/corrossion study with dihydrolinalool in the rabbit (4 -hour semi-occlusive application) was performed. The study was carried out based on the guidelines desccribed in: EC Commission Directive 92/69/EEC, B.4, "Acute Toxicity - Skin irriation" and OECD No. 404, "Acute Dermal Irritation/Corrosion".
Three rabbits were exposed to 0.5 ml of dihydrolinalool, applied onto clipped skin for 4 hours using a semi-occlusive dressing. Observations were made 1, 24, 48 and 72 hours and 7, 14 and 21 days after exposure.
Exposure to dihydrolinalool resulted in severe erythema and moderate to severe oedema in the treated skin-areas of the three rabbits. Due to fissuring of the skin observed in two animals after 72 hours, oedema could not be scored in one animal. Reduced flexibility of the skin was noted after 48 hours in one animal and after 72 hours in the other animals. Scaliness and a bald skin were seen in all animals after 7 and 14 days respectively. The skin irritation had resolved within 21 days after exposure in all animals.
Sticky or dry remnants of the test substance were present on the skin up to 72 hours in one animal and up to 7 days in the other animals.
Based on the results and according to the EC criteria for classification and labeling requirements for dangerous substances and preparation dihydrolinalool should be labelled as "irritating to skin (R38)".
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